Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

The addition of 0.5 weight percent (w/o) of the perfluorosulfonimide (PFSI), CF3SO2N(H)SO2C4Fg, as an additiveto 85% H3PO4 in hydrogen-oxygen fuel cell results in a 70 mV increase in the potential of the oxygen cathode (high surface area, 10% Pt on Vulcan XC-72) at current densities up to 500 mA cm 2 at 70oc. This improvement is proposed to be due to the enhanced oxygen reduction kinetics caused by a physically adsorbed layer of the PFSI on the catalyst with the fluorocarbon tail toward the surface. The adsorbed layer creates a "dry cave" environment adjacent to the electrode surface which favors the competitive adsorption of oxygen on the catalyst surface. This adsorbed layer apparently does not interfere with water or proton transfer from or to the interface. Flooding of the gas structure of the porous cathode has not been observed at 0.5 w/o of the PFSI but has been observed at higher concentrations. ABSTRACTThe enhancement of limiting currents by inert suspended solids was studied using a rotating-disk electrode (RDE). The suspensions contained glass or polymer particles in various sizes (1-100 ~m) and concentrations (up to 40 v/o solids). Solid particles the same size as, or smaller than, the thickness of the mass-transfer boundary layer create small-scale "microconvective" vortices. Particles much larger than the boundary-layer thickness appear to enhance transport by a different mechanism, possibly involving the formation of particle-free wall layers. Disk-torque measurements show that sub-

<p class="abstract"><strong>Background:</strong> The incidence of usage of over-the-counter drugs is drastically increasing day by day. Over-the-counter (OTC) drugs are medicines sold directly to consumer without a prescription from health care personnel. In many countries, OTC drugs are selected by a regulatory agency to ensure that they are safe and effective when used without physician’s care. Taking OTC medicines still has risk. Some interact with other medicines, supplements, food and drinks and some causes problem for people with certain medical conditions.</p><p class="abstract"><strong>Methods:</strong> A descriptive cross sectional was conducted from 1st February - 15th August 2016 among 110 among adults of age group 20 and above residing in Chapapani-12, Pokhara. A pre-tested structured questionnaire were used and data were analyzed using Statistical Package for Social Science (SPSS) for windows version 18.0. Frequency, percentage, chi-square and correlation were performed.  </p><p class="abstract"><strong>Results:</strong> Nearly 1/3^rd of the respondents (33.6%) were of age group 20-29 years and more than half (60.9%) were female. More than half of the respondents (54%) had good knowledge and less than half (47%) had good practice of OTC. There was significant association of knowledge with age, marital status, education and monthly family income. There was significant association of practice with education of respondents. There was weak positive correlation between knowledge and practice (r =0.211).</p><strong>Conclusions:</strong> This showed that the knowledge hadn’t been fully practiced into action by the community people and still they are lacking the concept of over-the-counter drugs and its safe use in daily living.

A transition-metal-free regioselective α-arylation of coumarins and 2-pyridones has been accomplished by the reaction of phenylhydrazines with coumarins or 2-pyridones.