The Biological Significance of Selenium and Its Place in Rna Viral Diseases

Abstract

ABSTRACT. Selenium as an essential trace element takes part in the regulation of many vital processes. This is realized with the help of over 25 selenoproteins that affect oxidative stress, immune response, hormonal metabolism, cognitive function, etc. Recently (in the next 30 - 40 years), there have been reports of the effect on viral infections, which have now become widespread. It turned out that almost all RNA viruses are selenium-dependent objects, that is, their genome contains the codes of the most important selenium containing proteins, including such as glutathione peroxidase, thioredoxinreductase, selenium-P protein, etc. Their synthesis during the development of a viral infection at the expense of the host leads to a weakening of the synthesis of the body's own intracellular selenium proteins, which contributes to the development of oxidative stress and a failure of the immune response. And this leads to the devastation of the selenium depot of the body, intended for the synthesis of its selenium proteins, which participate in vital regulatory processes. This circumstance determines, to replenish the body's resources with selenium, the expediency of using selenium-containing pharmacopoeia preparations as adjuvant in the treatment of RNA viral infections.

Trace Elements Zinc and Selenium: Their Significance in the Conditions of the COVID-19 Pandemic

“…Selenium is the second most important trace element in our time. As an essential trace element, it is involved in many life-important processes, implemented with the help of 25 selenium proteins which aff ect oxidative stress, hormonal metabolism, cognitive functions, and most importantly, the immune response [20].…”

“…Selenium, like zinc, is believed to play a key role in the maintenance of immunity and has long been known as a regulator of the immune response at all levels of nonspecifi c humoral and cellular immunity [23,24]. Th erefore, the level of selenium in the diet of the population can be of great importance during the COV-ID-19 pandemic, both at the beginning of the disease and for the severity of the disease and its complications, caused by the violation of the immune response and the development of oxidative stress [20].…”

“…Th ere is a practice of using zinc as a potential means of immune support and prevention of infl uenza H1N1 (swine-origin infl uenza A viruses) [10]. Selenium, like zinc, plays a key role in maintaining immunity and has long been known as a regulator of the immune response at all levels of nonspecifi c humoral and cellular immunity [20][21][22][23][24]. Th ere is an inverse correlation between the mortality rate from COVID-19 and the level of selenium intake.…”

“…(повтор). At the same time, the defi ciency of selenium in the diet of the population has a global scale [15][16][17][18][19][20][26][27][28].…”