The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer

Abstract

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Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids

“…A key step in protein synthesis is the recognition of codons by mature transfer RNAs (tRNAs) charged with their corresponding amino acids ( 33 ). We have recently developed a qRT-PCR–based assay for quantifying 57 human mature tRNA species that collectively constitute the tRNAome ( 34 ). We previously found that HEV infection in the Huh7 cell line profoundly reprogrammed tRNAome with most of the tRNA species that were up-regulated ( 35 ).…”

Lactiplantibacillus plantarum 0111 Protects Against Influenza Virus by Modulating Intestinal Microbial-Mediated Immune Responses

“…Viral infection heavily relies on host transfer RNA (tRNA) for viral RNA decoding, which is a major determinant of the success of viral infection ( Ou et al, 2020 ). Factors controlling tRNA use in the intestine remain unexplored, but microbiome and virome can influence this, and thus by inference, L. plantarum could as well ( Zhang et al, 2021 ). There is increasing evidence that probiotics provide immune protection by regulating multiple aspects of the innate and adaptive immune systems ( Giorgetti et al, 2015 ).…”

The Role of tRNA-Centered Translational Regulatory Mechanisms in Cancer

“…Both oncogenes and tumor suppressor pathways have the capacity to modulate tRNA synthesis. Furthermore, alterations in the tRNA pool can exert a significant influence on mRNA translation and cellular growth [ 16 ]. The human genome contains 61 different sense codons, several of which are synonymous and encode the same amino acids.…”