The biological function and formation of the cyano group

Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety

“…The significant biological and medical activity of the arylhydrazone of α-cyanoketone as an antituberculosis agent 34 and oxidative phosphorylation inhibitor 35 have (18), respectively. The IR spectrum of 17 showed the presence of two NH 2 and two NH absorption bands at 3434-3400 cm -1 , the C=S group at 1325 cm -1 and the absence of CN groups.…”

Nickel-Catalyzed Selective C–H Cyanation via Aromatic Thianthrenium Salts

“…Nitriles are important building blocks in organic synthesis, especially aryl nitriles are important parts of structural motifs in dyes, pesticides, pharmaceutical compounds, and electronic materials (Figure a). Moreover, the cyano group also serves as a versatile intermediate for the preparation of many compounds such as aldehydes, amines, tetrazoles, and amides employing transformations such as hydrolysis, hydration, reduction, or addition. , The Sandmeyer reaction and Rosenmund-Von Braun protocol are the most convenient methods for obtaining aryl nitriles.…”

The Effect of Chlorination on Organocyanide Compounds

“…Nitriles are widely used as solvents in chemical processing (e.g., acetonitrile), and are expected components in industrial wastewaters. In the natural environment, different nitrile compounds have been found in shale oil (Harvey et al, 1988), in different components of some plants (Knowles, 1976) or as a plant-growth hormone (Ferris, 1970), and in the glands of some arthropods (Moore, 1967, andEisner et al, 1963). There are several classes of nitriles found naturally or synthesized chemically, the most common of which are cyanohydrins and cyanogenic glycosides.…”

“…Cyanogenic glycosides are synthesized by many plants, such as apricots, peaches, lima beans, white clover, and almonds, and are also capable of liberating hydrogen cyanide on hydrolysis (Seigler, 1974). Two steps are involved in the hydrolysis, the cleavage of the sugar moiety and the dissociation of the cyanohydrin to the aldehyde and cyanide (Ferris, 1970). Unlike common cyanohydrins that are prone to hydrolysis in acidic environments only, the cyanogenic glycosides need an enzyme system (referred to as emulsin) to catalyze the hydrolysis (Ferris, 1970).…”

“…Two steps are involved in the hydrolysis, the cleavage of the sugar moiety and the dissociation of the cyanohydrin to the aldehyde and cyanide (Ferris, 1970). Unlike common cyanohydrins that are prone to hydrolysis in acidic environments only, the cyanogenic glycosides need an enzyme system (referred to as emulsin) to catalyze the hydrolysis (Ferris, 1970). Cyanogenic glycosides are expected components in wastewater from food sources (Balagopalan and Rajalakshmy, 1998).…”