The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

Waniczek, Dariusz; Mikusek, Wojciech; Kamiński, Tomasz; Wesecki, Mariusz; Lorenc, Z. Paul; Cieślik-Bielecka, A.

doi:10.1515/pjs-2015-0055

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…All patients in this study showed complete resolution of these ulcers over 4-10 weeks after receiving adjunctive PRP therapy. 84 Another retrospective study examined 39 patients with chronic lower extremity wounds to evaluate the effectiveness of standard protocols combined with PRP gel. 85 This study demonstrated that the addition of PRP gel promoted wound healing after an average of 145 days in 83% of the wounds and decreased the amputation rate.…”

Section: Treatment For Chronic Ulcersmentioning

confidence: 99%

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Zhang

Guo

Kuss

et al. 2019

Tissue Engineering Part B: Reviews

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The management and treatment of tissue infection, especially chronic infection, represents a significant challenge. Application of autologous platelet-rich plasma (PRP) has emerged as a promising adjunct therapy for facilitating the healing of surgical wounds and tissue injuries. PRP is extracted from whole blood using a sequential centrifugation technique and when activated, can release a vast array of antimicrobial proteins, cytokines, and growth factors. These bioactive molecules are responsible for the ability of PRP to kill pathogens, resolve necrotic tissue, and promote wound healing. PRP is emerging as a useful supplement to prevent postoperative infection and treat chronic wound or bone infections. PRP displays a synergistic effect with antibiotics, which provides unique advantages when treating antibiotic-resistant bacteria. This review will describe the method for PRP preparation and its antibacterial properties, as well as discuss both preclinical in vivo results and evidence from clinical practice of PRP use for the treatment of wound and bone infections.

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Section: Treatment For Chronic Ulcersmentioning

confidence: 99%

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Zhang

Guo

Kuss

et al. 2019

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

show abstract

“…Plasma is used in surgery, sports medicine and traumatology for the treatment of chronic wounds and in aesthetic medicine (12,13). Autologous platelet-rich plasma (PRP) is a source of many growth factors that play a key role in the process of normal wound healing, such as platelet-derived growth factor (PDGF), transforming growth factor-b (TGF-b) and vascular endothelial growth factor (VEGF) (13).…”

mentioning

confidence: 99%

“…Autologous platelet-rich plasma (PRP) is a source of many growth factors that play a key role in the process of normal wound healing, such as platelet-derived growth factor (PDGF), transforming growth factor-b (TGF-b) and vascular endothelial growth factor (VEGF) (13). In addition, the leukocytes present in the preparation increase its antibacterial properties (12). Having been administered plasma, patients may take fewer standard drugs, which is particularly important in the case of concurrent diseases.…”

mentioning

confidence: 99%

Influence of plasma on the physical properties of ointments with quercetin

et al. 2017

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Effects of two independent variables -the content of quercetin (0 or 1 or 1.5 or 5 %) and the content of plasma (0 or 2 or 4 or 6 %) -on the organoleptic properties and rheological parameters of model formulations prepared on an amphiphilic base were estimated. The consistency of all ointments was uniform, and the content of quercetin and plasma lay within the predefined range. Tested ointments are non-Newtonian systems. The content of quercetin and plasma was found to have a significant effect on the rheological properties of the ointments. An increase in the content of plasma in ointments was accompanied by a significant increase in their hardness, viscosity and shear stress and a reduction of their spreadability. The best rheological properties were shown by formulation F-3, containing 1.5 % of quercetin and 2 % of plasma.

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“…Prospective Cohort FT = 1 year Leucocyte-and platelet-rich fibrin (L-PRP) (n = 32) 2b/B Waniczeket al (21) 2015 Poland…”

Section: Resultsmentioning

confidence: 99%

Cost and effectiveness of Platelet Rich Plasma in the healing of varicose ulcer: Meta-analysis

2020

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ABSTRACT Objectives: to analyze the evidence on the cost and effectiveness of Plaque Rich Plasma in the treatment of venous ulcers compared to other topical therapies. Methods: systematic review, with search in the databases: COCHRANE, EMBASE, MEDLINE via PubMed, LILACS, CINAHL, SCOPUS, without temporal cut and in the English, Portuguese and Spanish languages. Results: fifteen articles were included, a cost-minimization analysis showed that the cost of Plaque Rich Plasma is € 163.00 ± 65.90, slightly higher than the cost of standard dressing. Regarding effectiveness, the results of the studies associated with the meta-analysis suggest a tendency that Plaque Rich Plasma is effective in the healing of venous ulcers. Conclusions: it is concluded that there are few studies about the cost of Platelet Rich Plasma and this product tends to be effective in the healing of venous ulcers. However, more controlled and randomized clinical studies are necessary in order to establish a stronger recommendation.

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The “biological chamber” method – use of autologous platelet-rich plasma (PRP) in the treatment of poorly healing lower-leg ulcers of venous origin

Abstract: The presented method seems technically simple, effective and relatively inexpensive.

Cited by 5 publications

References 25 publications

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

Influence of plasma on the physical properties of ointments with quercetin

Cost and effectiveness of Platelet Rich Plasma in the healing of varicose ulcer: Meta-analysis

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