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Existing evidence supports compression therapy as the most critical element in the management of venous leg ulcers. However, evidence also suggests that surgical obliteration of incompetent perforator veins may promote longer ulcerfree periods and lower rates of recurrence.

Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.

ABSTRACT Objectives: to translate and cross-culturally adapt the Leg Ulcer Measurement Tool to Brazilian Portuguese. Methods: methodological study involving the steps of initial translation, synthesis of translations, back-translation, expert panel and pretest. For analysis by the expert committee, the content validity index was calculated and in the pretest for practicality, the agreement rate was calculated. Satisfactory agreement was considered when > 0.8 and 80%, respectively. Results: the initial steps of translation were satisfactorily developed and there was little disagreement between the translators. In the expert panel, was obtained significant concordance of 0.97. The pretest was performed with ten nurses and 30 patients. The feasibility of the translated version was evaluated with 100% agreement. Final Considerations: the instrument presented a high level of concordance among the experts during all steps and showed content validity thereby making the adaptation appropriate for the Brazilian context.

Objetiva-se analisar os instrumentos/escalas de avaliação clínica para úlceras de perna disponíveis na literatura. Trata-sede uma revisão integrativa nas bases: PubMed/Medline, CINAHL, SCOPUS e LILACS. Foram considerados estudos queutilizaram instrumentos valorados e avaliados clinicamente pelo profissional sem utilização de outras tecnologias. Não foiestabelecido recorte temporal e restrição de idiomas. Foram analisados 12 estudos, totalizando 10 instrumentos/escalas (3estudos discorriam sobre o mesmo instrumento). Os parâmetros/itens dos instrumentos avaliados têm concordância de50% em relação à área, profundidade, tecido, exsudato e infecção. Outros itens observados foram: dor, presença de tecidonecrótico, borda da ferida e edema. Conclui-se que os instrumentos/escalas apontam concordância em relação à avaliaçãodo tamanho da lesão, aspecto e infecção, entretanto, divergem em outros pontos. Cabe ao profissional identificar o quemais atende ao perfil da população alvo e a disponibilidade para uso em seu país.Palavras-chave: Escalas; Instrumentos; Feridas; Úlcera da Perna; Úlcera do Pé. ABSTRACTThis research aims to analyze the instruments/clinical assessment scales for leg ulcers available in the literature. This isan integrative review study in the databases: PubMed/Medline, CINAHL, SCOPUS e LILACS. Were included studies thatused instruments valued and evaluated clinically by the professional without the use of other technologies. No temporalclipping and language restriction were established. Twelve studies were analyzed, totaling 10 instruments/scales (3 studieswere based on the same instrument). The parameters/items of the evaluated instruments have a 50% agreement regarding:area, depth, tissue, exudate and infection. Other items observed were: pain, presence of necrotic tissue, wound borderand edema. It concludes that the instruments/scales show agreement regarding the evaluation of lesion size, appearanceand infection, however they differ in other points. It is up to the professional to identify what most suits the profile of thetarget population, in addition to what is available for use in their country.Keywords: Scales; Instruments; Wounds; Leg Ulcer; Foot Ulcer

Practice improvements are needed including establishing institutional drug administration protocols and keeping them updated, using a computerized prescription system, and promoting patient safety with staff.

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