The biocompatability of mesoporous inorganic–organic hybrid resin films with ionic and hydrophilic characteristics

Kim, Hyung-Seok; Hong, Lan; Jung, Jungwoon; Kim, Dong‐Pyo; Kim, Hee‐Soo; Kim, Ik Jung; Kim, Jung Ran; Ree, Moonhor

doi:10.1016/j.biomaterials.2009.12.013

Cited by 38 publications

(30 citation statements)

References 44 publications

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“…In some visual field, a single SC could be seen located on the KBC fibers as shown in Figure (E). Generally, the properties of cell adhesion and spreading on the tested materials mainly depend on the surface solidity, surface charge density, and hydrophilicity or water sorption of the substrate . Thus, the excellent adhesion, spreading, and proliferation performances of SCs on the KBC membranes are attributed to the hydrophilic and solid characteristics.…”

Section: Resultsmentioning

confidence: 99%

“…The in vivo biocompatibility of a biomaterial is essential in determining potential application of the material for nerve regeneration, and ensuring the efficacy and safety of a nerve conduit prepared by the material . After KBC conduits were implanted into rats, routine blood tests showed that there were no significant differences between the implanted rats and sham‐operated rats at the same time point (Table ).…”

Section: Resultsmentioning

confidence: 99%

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Kombucha‐synthesized bacterial cellulose: Preparation, characterization, and biocompatibility evaluation

Zhu

Feng

Zhou

et al. 2013

J Biomedical Materials Res

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Bacterial cellulose (BC) is a natural biomaterial with unique properties suitable for tissue engineering applications, but it has not yet been used for preparing nerve conduits to repair peripheral nerve injuries. The objectives of this study were to prepare and characterize the Kampuchea-synthesized bacterial cellulose (KBC) and further evaluate the biocompatibility of KBC with peripheral nerve cells and tissues in vitro and in vivo. KBC membranes were composed of interwoven ribbons of about 20-100 nm in width, and had a high purity and the same crystallinity as that of cellulose Iα. The results from light and scanning electron microscopy, MTT assay, flow cytometry, and RT-PCR indicated that no significant differences in the morphology and cell function were observed between Schwann cells (SCs) cultured on KBC membranes and glass slips. We also fabricated a nerve conduit using KBC, which was implanted into the spatium intermusculare of rats. At 1, 3, and 6 weeks post-implantation, clinical chemistry and histochemistry showed that there were no significant differences in blood counts, serum biochemical parameters, and tissue reactions between implanted rats and sham-operated rats. Collectively, our data indicated that KBC possessed good biocompatibility with primary cultured SCs and KBC did not exert hematological and histological toxic effects on nerve tissues in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Kombucha‐synthesized bacterial cellulose: Preparation, characterization, and biocompatibility evaluation

Zhu

Feng

Zhou

et al. 2013

J Biomedical Materials Res

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“…However, all the hybrid coatings prove more biocompatible than inorganic ones. This means that PEG improves the films biocompatibility probably by two mechanisms: first acting as plasticizer and, thus, allowing crack‐free coatings to be obtained ; second, inducing a surface hydrophilicity increase which favors protein adhesion .…”

Section: Resultsmentioning

confidence: 99%

PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications

Catauro¹,

Papale²,

Piccirillo³

et al. 2017

Polymer Engineering & Sci

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In the present work, the application of functional coatings on metallic implants was proposed to delay implant failure by improving tissue tolerance and implant osseointegration. Three bioactive and biocompatible organic–inorganic hybrid nanocomposites, consisting of polyethylene glycol (PEG) embedded in a SiO2, ZrO2, and TiO2 matrix, respectively, were synthesized via the sol–gel method. Materials in the sol phase were used to dip‐coat titanium grade 4 substrates for use as dental and orthopedic implant models. To investigate the influence of the glass matrix and the polymer amount on the coating structure, and thus on their biological properties, several hybrids were obtained by adding different weight percentages of PEG to each glass matrix. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the presence of the polymer in the nanocomposites and scanning electron microscopy showed that an increase in the PEG content allows crack‐free coatings to be obtained. Moreover, the bioactivity and biocompatibility of both the uncoated and coated titanium implants were investigated and compared by an in vitro test. The results revealed that coated substrates have more enhanced biological performance than the uncoated ones. The bioactivity is not significantly affected by either the inorganic matrix or the PEG amount, whereas the presence of polymer makes the films more biocompatible. POLYM. ENG. SCI., 57:478–484, 2017. © 2017 Society of Plastics Engineers

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“…Recently, a 5′-NH 2 -modified PSMA aptamer was chemically synthesized and covalently decorated on the surface of a polymer composed of branched PEI grafted with PEG (PEI-PEG) for co-delivery of shRNA and chemotherapy agents (Kim et al, 2010; Figure 2D). In this design, PEG serves as a spacer to separate positively charged PEI from aptamers, avoiding the interference with the active folding of aptamers.…”

Section: Rna Aptamer-mediated Targeted Therapymentioning

confidence: 99%

Current Progress of RNA Aptamer-Based Therapeutics

Zhou¹,

Bobbin²,

Burnett³

et al. 2012

Front. Gene.

117

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Aptamers are single-stranded nucleic acids that specifically recognize and bind tightly to their cognate targets due to their stable three-dimensional structure. Nucleic acid aptamers have been developed for various applications, including diagnostics, molecular imaging, biomarker discovery, target validation, therapeutics, and drug delivery. Due to their high specificity and binding affinity, aptamers directly block or interrupt the functions of target proteins making them promising therapeutic agents for the treatment of human maladies. Additionally, aptamers that bind to cell surface proteins are well suited for the targeted delivery of other therapeutics, such as conjugated small interfering RNAs (siRNA) that induce RNA interference (RNAi). Thus, aptamer-siRNA chimeras may offer dual-functions, in which the aptamer inhibits a receptor function, while the siRNA internalizes into the cell to target a specific mRNA. This review focuses on the current progress and therapeutic potential of RNA aptamers, including the use of cell-internalizing aptamers as cell-type specific delivery vehicles for targeted RNAi. In particular, we discuss emerging aptamer-based therapeutics that provide unique clinical opportunities for the treatment various cancers and neurological diseases.

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The biocompatability of mesoporous inorganic–organic hybrid resin films with ionic and hydrophilic characteristics

Cited by 38 publications

References 44 publications

Kombucha‐synthesized bacterial cellulose: Preparation, characterization, and biocompatibility evaluation

Kombucha‐synthesized bacterial cellulose: Preparation, characterization, and biocompatibility evaluation

PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications

Current Progress of RNA Aptamer-Based Therapeutics

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