The biobank of the Norwegian Mother and Child Cohort Study – present status

Paltiel, Liv; Haugan, A.; Skjerden, Trine; Harbak, Kari; Bækken, Siri; Stensrud, Nina Kristin; Knudsen, Gun Peggy; Magnus, Per

doi:10.5324/nje.v24i1-2.1755

Cited by 135 publications

(139 citation statements)

References 11 publications

(15 reference statements)

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…Our study specifically addressed post-separation time delays, as was typical for plasma in the Norwegian Mother and Child Cohort Study 16,26 (eTable 1). Although pre-separation delay may be more relevant for the Danish National Birth Cohort 4,27 , a previous study has indicated that thyroid hormone biomarkers in plasma and sera are similarly stable in room temperature with up to 72 hours delay in blood separation 17 .…”

Section: Discussionmentioning

confidence: 99%

Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women’s Plasma

et al. 2017

View full text Add to dashboard Cite

Background Maternal thyroid function is a critical mediator of fetal brain development. Pregnancy-related physiologic changes and handling conditions of blood samples may influence thyroid hormone biomarkers. We investigated the reliability of thyroid hormone biomarkers in plasma of pregnant women under various handling conditions. Methods We enrolled 17 pregnant women; collected serum and plasma were immediately frozen. Additional plasma aliquots were subjected to different handling conditions before the analysis of thyroid biomarkers: storage at room temperature for 24 or 48 hours before freezing and an extra freeze–thaw cycle. We estimated free thyroid hormone indices in plasma based on T3 uptake. Results High correlations between plasma and serum (>0.94) and intra-class correlation coefficients for plasma handling conditions (0.96 to 1.00) indicated excellent reliability for all thyroid hormone biomarkers. Conclusion Delayed freezing and freeze–thaw cycles did not affect reliability of biomarkers of thyroid function in plasma during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women’s Plasma

et al. 2017

View full text Add to dashboard Cite

show abstract

“…At the biobank repository, DNA was extracted and stored at −20°C until analysis. For details of sample handling, see …”

Section: Methodsmentioning

confidence: 99%

Maternal microchimerism in cord blood and risk of childhood‐onset type 1 diabetes

Tapia

Mortimer

et al. 2019

Pediatr Diabetes

View full text Add to dashboard Cite

Background Maternal microchimerism (MMc), the transmission of small quantities of maternal cells to the fetus, is relatively common and persistent. MMc has been detected with increased frequency in the circulation and pancreas of type 1 diabetes (T1D) patients. We investigated for the first time whether MMc levels at birth predict future T1D risk. We also tested whether cord blood MMc predicted MMc in samples taken at T1D diagnosis. Methods Participants in the Norwegian Mother and Child Cohort study were human leukocyte antigen (HLA) class II typed to determine non‐inherited, non‐shared maternal alleles (NIMA). Droplet digital (dd) polymerase chain reaction (PCR) assays specific for common HLA class II NIMA (HLADQB1*03:01, *04:02, and *06:02/03) were developed and validated. MMc was estimated as maternal DNA quantity in the fetal circulation, by NIMA specific ddPCR, measured in cord blood DNA from 71 children who later developed T1D and 126 controls within the cohort. Results We found detectable quantities of MMc in 34/71 future T1D cases (48%) and 53/126 controls (42%) (adjusted odds ratio [aOR] 1.27, 95% confidence interval (CI) 0.68‐2.36), and no significant difference in ranks of MMc quantities between cases and controls (Mann‐Whitney P = .46). There was a possible association in the NIMA HLA‐DQB1*03:01 subgroup with later T1D (aOR 3.89, 95%CI 1.05‐14.4). MMc in cord blood was not significantly associated with MMc at T1D diagnosis. Conclusions Our findings did not support the hypothesis that the degree of MMc in cord blood predict T1D risk. The potential subgroup association with T1D risk should be replicated in a larger cohort.

show abstract

“…Blood samples were collected from participants at the time of the routine ultrasound examination and shipped at ambient temperature to the MoBa biorepository in Oslo (22). Samples were collected from women between approximately 17–20 weeks gestation.…”

Section: Methodsmentioning

confidence: 99%

Maternal Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Breastfeeding Duration in the Norwegian Mother and Child Cohort

Rosen

Brantsæter

Carroll

et al. 2018

Environmental Epidemiology

View full text Add to dashboard Cite

Background Per- and polyfluoroalkyl substances (PFASs) have been widely produced, many of them persist in the environment, and have been associated with various health effects. Previous studies have identified inverse associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and breastfeeding duration, but have been limited in investigation of other PFASs. Methods We measured the associations between plasma concentrations of 9 different PFASs and cessation of breastfeeding before 3 and 6 complete months using women from the Norwegian Mother and Child Cohort Study (MoBa). The study population includes 1716 primarily nulliparous women from two previous studies of MoBa participants, enrolled from 2003–2007. The association was measured using Cox proportional hazards model. Mixtures analyses were performed using Elastic net regularization to identify interactive effects and control for co-pollutant confounding. Results Concentrations of PFASs in this population were lower than concentrations in the previous studies on this topic. We found associations between increasing concentrations of perfluorononanoic acid (PFNA), perfluorodecaconic acid (PFDA), perfluoroundecanoic acid (PFUnDA) and decreased breastfeeding cessation (increased duration). The strongest associations were seen between PFDA and PFUnDA and cessation before 3 months: (both hazard ratios = 0.73, 95% confidence intervals: 0.62, 0.86). In our population, the other PFASs appeared to be unassociated with breastfeeding cessation. The mixtures analyses identified meaningful interactions between PFUnDA:PFDA, perfluorohexane sulfonate (PFHXS):PFOA and PFOA:PFOS. Conclusions The identification of associations between previously unexamined PFASs concentrations and increased breastfeeding duration is novel and may be explained by differences in transplacental transfer rates.

show abstract

The biobank of the Norwegian Mother and Child Cohort Study – present status

Abstract: -

Cited by 135 publications

References 11 publications

Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women’s Plasma

Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women’s Plasma

Maternal microchimerism in cord blood and risk of childhood‐onset type 1 diabetes

Maternal Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Breastfeeding Duration in the Norwegian Mother and Child Cohort

Contact Info

Product

Resources

About