The bidirectional relationship between endometriosis and microbiome

Uzuner, Cansu; Mak, Jason; El‐Assaad, Fatima; Condous, G.

doi:10.3389/fendo.2023.1110824

Cited by 20 publications

(14 citation statements)

References 99 publications

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“…This predisposition is believed to be reflected clinically in infertility, changes in the junctional zone [ 36 ], and severe dysmenorrhoea from the first menstruation onwards [ 37 ], even before endometriosis lesions have formed. Another consequence of this predisposition is the high risk of initiating endometriosis lesions soon after puberty [ 38 ], when the oxidative stress of retrograde menstruation or infection or the microbiome [ 39 ] increases the risk of additional incidents.…”

Section: Results: the 10 “Cardinal Sins”mentioning

confidence: 99%

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach

Koninckx

Ussia²,

Gordts³

et al. 2023

JCM

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Evidence-based data for endometriosis management are limited. Experiments are excluded without adequate animal models. Data are limited to symptomatic women and occasional observations. Hormonal medical therapy cannot be blinded if recognised by the patient. Randomised controlled trials are not realistic for surgery, since endometriosis is a variable disease with low numbers. Each diagnosis and treatment is an experiment with an outcome, and experience is the means by which Bayesian updating, according to the past, takes place. If the experiences of many are similar, this holds more value than an opinion. The combined experience of a group of endometriosis surgeons was used to discuss problems in managing endometriosis. Considering endometriosis as several genetically/epigenetically different diseases is important for medical therapy. Imaging cannot exclude endometriosis, and diagnostic accuracy is limited for superficial lesions, deep lesions, and cystic corpora lutea. Surgery should not be avoided for emotional reasons. Shifting infertility treatment to IVF without considering fertility surgery is questionable. The concept of complete excision should be reconsidered. Surgeons should introduce quality control, and teaching should move to explain why this occurs. The perception of information has a personal bias. These are the major problems involved in managing endometriosis, as identified by the combined experience of the authors, who are endometriosis surgeons.

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Section: Results: the 10 “Cardinal Sins”mentioning

confidence: 99%

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach

Koninckx

Ussia²,

Gordts³

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…Wei et al (116) showed that Gram-negative bacteria can increase the number and volume of lesions and the number of macrophages in a mouse model of EMs by producing GUS. Other researchers have shown that there are significant differences in the gut microbiome in EMs patients compared to normal individuals, and the levels of expression of inflammatory factors, nuclear factors-κB p65, and cyclooxygenase-2 increased in EM patients (117). This suggests that an imbalance of the gut microbiome activates the inflammatory pathway of the gut-brain axis and participates in the progression of EMs.…”

Section: Gut Dysbiosis and Emsmentioning

confidence: 92%

The effect of the female genital tract and gut microbiome on reproductive dysfunction

Cao,

Fu,

Zhou

et al. 2023

BST

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Microorganisms are ubiquitous in the human body; they are present in various areas including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between the microbiome and reproductive health has become an increasingly compelling area of study. Disruption of the female genital tract microbiome can significantly impact the metabolism of amino acids, carbohydrates, and lipids, increasing susceptibility to reproductive tract diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, and polycystic ovary syndrome. The gut microbiome, considered an endocrine organ, plays a crucial role in the reproductive endocrine system by interacting with hormones like estrogen and androgens. Imbalances in the gut microbiome composition can lead to various diseases and conditions, including polycystic ovary syndrome, endometriosis, and cancer, although research on their mechanisms remains limited. This review highlights the latest advancements

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“…To date, correction of the gut microbiota with antibiotics, probiotics, or fecal bacterial transplantation is a hopeful method for improving the clinical management of endometriosis. [49,50,51] Authors Contribution:…”

Section: Medical Treatmentmentioning

confidence: 99%

Endometriosis: Pathogenesis, diagnosis, treatment and the role of gut microbiota

Senat,

Grabowska,

Senat

et al. 2024

J Educ Health Sport

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Endometriosis is a common disease. It affects 5-10% of women of reproductive age worldwide. However, despite the prevalence, diagnosis is typically delayed by years, misdiagnosis is common, and effective treatment takes years to achieve. Determining the mechanisms involved in its pathogenesis is vital, not only to pave the way for early identification, but also for disease management and development of less invasive but successful treatment strategies. Three main typed of endometriosis have been described in literature: peritoneal, ovarian and deep infiltrative. This is mainly due to the most common locations of ectopis endometrium. .Determining the precise pathogenesis of endometriosis has proved challenging and controversial for gynecologists, endocrinologists and researchers, but recent studies have focused on finding answers. This disease is often asymptomatic and diagnosed incidentally during various surgical interventions or follow-up gynecological examinations. Epidemiological research reports that women with this disease are more vulnerable to ovarian and breast cancer, asthma, skin cancer suhc as melanoma, cardiovascular disease and rheumatoid arthritis. The connection of the gut microbiota and endometriosis is nowadays higly suspected to exist. Scientists are focused on the influence of the microbiome on estrogens, estrogens-dependent disorders, immune system and inflammation. It is strongly velieved that correction of the gut microbiota with antibiotica, probiotics, or fecal bacterial transplantation sie a hopeful method for improving the clinical management of endometriosis.

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The bidirectional relationship between endometriosis and microbiome

Cited by 20 publications

References 99 publications

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach

The effect of the female genital tract and gut microbiome on reproductive dysfunction

Endometriosis: Pathogenesis, diagnosis, treatment and the role of gut microbiota

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