The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

Abstract

Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine. The chemical constituents of D. officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives. 13 bibenzyl derivatives from D. officinale were sent for molecular docking, surface plasmon resonance (SPR) assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells, it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins. In addition, HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives. The results show that bibenzyl derivatives could directly bind to SIRT3, enhance the deacetylation and then activate Mn-SOD, so as to protect UV-B induced skin photoaging. Graphical Abstract

<i>Dendrobium officinale</i> Extract Fermented with <i>Lactobacillus plantarum</i> GT-17F Enhances the Protection of UV-Mediated Photoaging

“…54) It has been reported that, bibenzyl derivatives as the main composition of D. officinale can protect cells from UVB irradiation induced photoaging by activating Sirtuin-3 (SIRT-3) activity. 55) According to these research results, the anti-photoaging mechanism of D. officinale is not very clear, and most reports show that active components in D. officinale can play a role in a certain metabolic pathway. Therefore, different from other manuscripts, in which the anti-photoaging effect of DOP-1 generated after fermentation of D. officinale was characterized, we extracted all the active components after fermentation of D. officinale and comprehensively analyzed its anti-photoaging effect.…”

Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity

“…The GLUT-1 protein solution was fixed on the surface of the Series S CM5 Sensor chip (GE Healthcare) with binding and deionization times of 120 and 150 s, respectively, and then the CSGs solution (25, 50, 100, 200, 400 µg/mL) passed through the sensor surface at a speed of 30 µL/min. The Kinetics and affinity analyses of CSCs at different concentrations were calculated by Biacore S200 evaluation software (GE Healthcare) [ 35 ].…”

Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

“…1,2 In Vietnam, D. officinale has been found in the mountains and forests of Vinh Phu, Quang Tri, Quang Nam, Da Nang, Gia Lai, Lam Dong provinces. The previous studies reported terpenoids, 3 bibenzyl derivatives, [1][2][3][4][5][6][7] polysaccharides, [8][9][10][11][12][13][14][15] are the main components of this plants. Some of which exhibited antitumor, 7,14,15 anti-inammatory activities [8][9][10][11][12][13] and alleviates type 2 diabetes mellitus.…”

“…9 Therefore, the whole plants of D. officinale were selected for further study. This paper reported the isolation, structural identication of thirteen triterpene glycosides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), including seven undescribed compounds (1)(2)(3)(4)(5)(6)(7) and their anti a-glucosidase and a-amylase activities in vitro.…”