The Benefits and Risks of Antioxidant Treatment in Liver Diseases

Abstract

Chronic liver diseases are a public health issue, because of their high incidence and prevalence, the important impact on the quality of life and high mortality rates. From a pathogenic point of view, in almost all liver diseases there is an increase in oxidative stress. Oxidative stress represents as an imbalance between the production of oxidizing agents and antioxidants. This imbalance contributes to the initiation and progression of hepatic injury. Among the most important risk factors for increased oxidative stress in chronic liver diseases are alcohol, drugs, environmental pollutants and irradiation. For the restoration of the oxidant-antioxidant balance and reduction of the oxidative stress in chronic liver diseases, a promising role may have the antioxidants. This hypothesis is now based on experimental evidence of their efficacy in animal models. In low concentrations, antioxidants improve liver function by preventing the oxidation of an oxidizable substrate, but in high doses, they may cause adverse reactions, such as the pro-oxidant effect, glutathione S transferase inhibition and thus the inhibition of detoxification and interference with coagulation. The objective of the article is to review the benefits of antioxidant treatment in chronic diseases of the liver, in order to put them in balance with their adverse reactions.

Ameliorating effect of pomegranate peel extract supplement against type 1 diabetes-induced hepatic changes in the rat: biochemical, morphological and ultrastructural microscopic studies

“…Dense bodies observed in rat hepatocytes of G 3: diabetic rats were most probably lysosomal structures that were previously described and associated with hepatocellular autophagy in alloxan-induced diabetes in male mice (43). The increase in the lysosomal structure was attributed to oxidative stress and increased free radical formation in diabetic status (44,45).…”

Correlations of the Mechanisms Involved in Diabetes Mellitus, Peripheral Arterial Disease and Gangrene Leading to Amputations-a Retrospective Study Over the Non-traumatic Amputations Performed in the Emergency Clinical County Hospital of Arad Between 2014- 2018

“…DM-associated atherosclerosis can lead to complications in all major of vascular beds, including the coronary arteries, carotid vessels, and lower extremity arteries [28, -30]. Free radicals are implied in these mechanisms [31,32]. Antioxidant mechanisms are activated and antioxidant treatments try to limit the consequences [33].…”

Implicaţiile medicale ale celulitei

“…Scăderi semnificative ale expresiei subcutanate a adiponectinei, hormon derivat de adipocite, cu funcţii antiinflamatoare, antifibrotice şi vasodilatatoare, pot juca un rol în patogeneza celulitei (22). În cazul pacienţilor cu celulită, pot să apară creşteri ale fenomenelor de stres oxidativ celular (23,24). Edemul ciclic idiopatic a fost asociat cu cazuri mai avansate de celulită, iar combinaţia dintre fumatul şi polimorfismul genei ACE a fost asociată semnificativ cu riscul de celulită (25).…”