The benefit of cinnamon (Cinnamomum burmannii) in lowering total cholesterol levels after consumption of high-fat containing foods in white mice (Mus musculus) models

Abstract

Background: Hypercholesterolemia is a condition where cholesterol levels in the body exceed the normal range. If the condition is longer, it can cause metabolic and cardiovascular diseases. The therapy of synthetic drugs has side effects that can be fatal (rhabdomyolysis). Needed to find natural remedies with minimal side effects. There are many nutritional components contained in cinnamon, such as cinnamaldehyde. The cinnamaldehyde, a substance that is thought to affect cholesterol levels. The study aims to determine the efficacy of Cinnamomum burmannii in lowering total cholesterol levels of mice (Mus musculus) given high-fat feed. Methods: This is an experimental study with a pre-post control study design. The groupings were performed by a simple random sampling method. The male mice were divided into five groups (n=6/group): 1) negative control (aquadest); 2) positive control of high-fat containing food (HFC; quail yolk); 3) HFC + cinnamon extract (CE; dose 2mg/20g body weight (BW); 4) HFC + CE (dose 4mg/20gBW); 5) HFC + CE (dose 8mg/20gBW). The study was conducted for 28 days. Consumption of quail yolk as HFC to increasing cholesterol in mice. The intervention of CE started on day 15 and ended on day 28. Measurement of total cholesterol and BW of mice was performed on days 0, 14 and 28. Results: The comparison of total cholesterol levels in the K1 group (120.3 ± 5.53 mg/dl) to K2 (107.3 ± 3.61 mg/dl), K3 (106.8 ± 4.57 mg/dl) and K4 (106.7 ± 0.51 mg/dl) showed decreased significantly different (p = 0.001) in groups consuming CE. However, there was not a significant change between groups in mice BW (p = 0.419). Conclusions: The cinnamon (Cinnamomum burmannii) proved can be lowering of total cholesterol levels for 14 days in mice compared without given cinnamon after consumption of high-fat containing foods.

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

“…In addition to Chinese cassia, other varieties of cinnamon have also been found to improve lipid metabolism. In hypercholesterolemia mice model induced by quail yolk, TC content in serum decreased after administration of cinnamon (Cinnamomum burmannii) for 28 days [41]. Similarly, cinnamon (Cinnamomum zeylanicum) bark extract supplement can reduce the blood levels of TC and TG in hyperlipidemia albino rats induced by Triton X-100 injection [42].…”

Cinnamon: an aromatic condiment applicable to chronic kidney disease

“…A meta-analysis that included 23 studies (1,070 subjects) concluded that there was no association between cinnamon consumption and differences in LDL-cholesterol, high-density lipoprotein cholesterol, and HbA1c levels. Studies on cinnamon in vitro, in animals, and in humans are listed in Table 5 [9,45,[131][132][133][134][135][136][137][138][139][140][141][142][143][144]. Again, allowance for different exposome features, such as microbiota composition, may be pertinent here [145].…”

Kemampuan Penurunan Kadar Kolesterol oleh Ekstrak Metanol Cinnamomum Burmanii Secara In Vitro

“…Beberapa obat penurun kolesterol bekerja pada proses metabolisme kolesterol yang terjadi di liver seperti statin, dengan cara menghambat kerja enzim HMGCoA sehingga pembentukan kolesterol terhambat (Vujkovic, 2024;Würtz et al, 2016). Terdapat juga obat yang bekerja pada proses penyerapan kolesterol pada usus halus dengan menghambat protein Niemann-Pick C1-like 1, seperti Ezetimebe (Wang et al, 2023) (Alsoodeeri et al, 2020;Pane & Pulungan, 2020). Hipotesa yang mendukung hasil penelitian tersebut berupa, aksi lipolitik kayu manis dari senyawa sinamaldehid.…”