Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Hu, Ying; Chen, Xingjuan; Hu, Mu; Zhang, Dongwei; Yuan, Shi‐Min; Li, Ping; Feng, Ling

doi:10.1186/s13020-022-00666-9

Cited by 20 publications

(12 citation statements)

References 201 publications

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“…In recent years, the prevalence of dyslipidemia in the Chinese population has been increasing, and dyslipidemia is one of the important independent risk factors for the development of cardiovascular diseases such as coronary heart disease and atherosclerosis [13,14]. The results of this study indicated that the detection rate of dyslipidemia in the elderly was 45.9%, and the prevalence of dyslipidemia in the Chinese population aged 60 years and older was 45.7% in a study by Li et al [14], consistent with the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis between sleep quality and dyslipidemia in the elderly

Xue

et al. 2023

Preprint

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Background: To provide a scientific basis for the early prevention of dyslipidemia, we investigate the relationship between sleep quality and dyslipidemia in the elderly. Methods: The survey subjects for questionnaires, physical measurements, and laboratory tests were permanent residents aged 65 years and older in a community who participated in physical examination at the Public Health Management Center of Zuoyun County Medical Group in Shanxi Province from August 2020 to September 2020. Questionnaires were used to collect the demographic characteristics and sleep status of the survey subjects to measure height, weight, and blood pressure; to collect fasting venous blood; and to determine total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). The association between sleep quality and dyslipidemia was determined by binary logistic regression models. Age, gender, current smoking, current drinking, obesity, and hypertension were adjusted as confounders. Odds-ratio (OR) with corresponding 95% confidence intervals (CI) were reported as effect measurements. Results: In 292 study subjects aged 65–92 (71.8 ± 5.1) years, the proportion of sleep disorders in the elderly was 40.4%, and the detection rate of dyslipidemia was 45.9%. The prevalence rates of abnormal TC, abnormal TG, and dyslipidemia were 27.1%, 28.0%, and 53.4%, respectively, in those with sleep disorders, which were significantly higher than those in those without sleep disorders (13.2%, 17.2%, and 40.8%, respectively). After further adjustment for age, gender, smoking, drinking, hypertension, and obesity, the aforementioned phenomena persisted, and having sleep disorders was a risk factor for abnormal TC [OR (95% CI) = 2.204 (1.160–4.190)], abnormal TG [OR (95% CI) = 1.904 (1.025–3.535)], and dyslipidemia [OR (95% CI = 1.741 (1.046–2.898)] (P < 0.05). Conclusions: Sleep quality in the elderly is strongly associated with the prevalence of abnormal TC, abnormal TG, and dyslipidemia, and sleep disorders may increase the risk of developing dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Correlation analysis between sleep quality and dyslipidemia in the elderly

Xue

et al. 2023

Preprint

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“…Therefore, the exploration for new products to prevent or treat MDs is of high and continued interest. In the last decade, scientific researchers turned their attention to phytochemicals as effective, safe and low-cost natural bioactive compounds for MD treatment [15][16][17][18]. Phytochemicals such as polyphenols, alkaloids and terpenoids have good antioxidative activity and antiinflammatory effects, due to their ability to bind free radicals with their functional groups.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Toma,

Deleanu,

Sanda

et al. 2024

IJMS

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Metabolic disorders (MDs), including dyslipidemia, non-alcoholic fatty liver disease, diabetes mellitus, obesity and cardiovascular diseases are a significant threat to human health, despite the many therapies developed for their treatment. Different classes of bioactive compounds, such as polyphenols, flavonoids, alkaloids, and triterpenes have shown therapeutic potential in ameliorating various disorders. Most of these compounds present low bioavailability when administered orally, being rapidly metabolized in the digestive tract and liver which makes their metabolites less effective. Moreover, some of the bioactive compounds cannot fully exert their beneficial properties due to the low solubility and complex chemical structure which impede the passive diffusion through the intestinal cell membranes. To overcome these limitations, an innovative delivery system of phytosomes was developed. This review aims to highlight the scientific evidence proving the enhanced therapeutic benefits of the bioactive compounds formulated in phytosomes compared to the free compounds. The existing knowledge concerning the phytosomes’ preparation, their characterization and bioavailability as well as the commercially available phytosomes with therapeutic potential to alleviate MDs are concisely depicted. This review brings arguments to encourage the use of phytosome formulation to diminish risk factors inducing MDs, or to treat the already installed diseases as complementary therapy to allopathic medication.

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“…), mulberry (Morus alba L.) leaf, and He-Shou-Wu (Polygonum multiflorum Thunb.) have been applied as healthcare food for fat reduction and weight loss (Gong et al, 2020;Y. Hu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…), mulberry ( Morus alba L.) leaf, and He‐Shou‐Wu ( Polygonum multiflorum Thunb.) have been applied as healthcare food for fat reduction and weight loss (Gong et al., 2020; Y. Hu et al., 2022). However, the specific mechanism of their anti‐obesity effects from the perspective of adipose browning remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Miquelianin, a main functional flavonoid of lotus leaf, induces thermogenic signature via p38‐PINK1‐PARKIN‐mediated mitophagy and mimicking NRF2 signaling during brown adipocyte differentiation

et al. 2023

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Adipocytes thermogenesis is an important mechanism for increasing energy expenditure. Here, screening of thermogenic activators (Sirt1 and Ucp1) investigated in C3H10T1/2 cells revealed ethanol extract of lotus leaf (LLE) may exert higher activity compared with that of the other 11 ingredients. UPLC‐MS/MS analysis showed that miquelianin was identified as the main flavonoid compounds in LLE (12.8%) and therefore deserves further investigation. The results in C3H10T1/2 cells revealed miquelianin promoted lipolysis, enhanced thermogenic programming (Sirt1, Ppargc1a, Prdm16, Cox7a, Nrf1, Cox2, and Ucp1), and induced brown‐like adipocyte formation (Fgf21, Cd137, Tmem26, Tbx1, Cd40, and Cited1). Moreover, miquelianin increased mitochondrial abundance, mitochondrial membrane potential, and NAD+/NADH ratio, suggesting its potential in mitochondria activity. We also observed that miquelianin improved mitochondrial quality by the establishment of mitochondrial dynamics (Mfn1, Mfn2, Opa1, Drp1, and Fis1) and subsequent suppression of autophagy. Chemical inhibition experiment revealed miquelianin may trigger browning via p38‐PINK1‐PARKIN‐mediated mitophagy. Furthermore, in ML385‐treated cells, NRF2, HMOX1, TFAM, and UCP1 were compromised by miquelianin treatment, suggesting that NRF2 signaling is necessary during miquelianin‐induced mitochondria biogenesis. Together, our findings demonstrate that miquelianin may induce browning and mitochondria thermogenic programing by suppressing mitophagy via p38‐PINK1‐PARKIN and mimicking NRF2 signaling.

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Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Cited by 20 publications

References 201 publications

Correlation analysis between sleep quality and dyslipidemia in the elderly

Correlation analysis between sleep quality and dyslipidemia in the elderly

Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders

Miquelianin, a main functional flavonoid of lotus leaf, induces thermogenic signature via p38‐PINK1‐PARKIN‐mediated mitophagy and mimicking NRF2 signaling during brown adipocyte differentiation

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