The beneficial role of vitamin D and its analogs in cancer treatment and prevention

Lương, Khanh vinh quốc; Nguyễn, Lan

doi:10.1016/j.critrevonc.2009.04.008

Cited by 32 publications

(26 citation statements)

References 112 publications

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“…39 In addition, the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3, was found to have the ability to avoid cell proliferation. 40 We found a prevalence of cervical HPV infection of 28.4%, which was higher than in some studies. Tam et al 21 found that 12.5% of SLE patients had a persistently high risk of HPV, which increased to 25% after three years.…”

Section: Discussioncontrasting

confidence: 73%

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

Garcı́a-Carrasco

Munguía‐Realpozo²,

Rodríguez-Gallegos

et al. 2014

Lupus

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Our objective was to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women with SLE. This is a cross-sectional study of 67 women with SLE. A structured questionnaire was administered to ascertain the possible risk factors associated with cervical HPV infection. A gynaecological evaluation and cervical cytology screening were made. HPV detection and genotyping was made by PCR and linear array assay. Serum 25 hydroxyvitamin D levels were quantified by chemiluminescence immunoassay. Mean age and disease duration were 44.8 ± 10.6 and 42.5 ± 11.8 years, respectively. Demographic characteristics were similar in patients with and without deficiency (<20 ng/ml and ≥20 ng/ml). There were 28.4% of women with cervical HPV infection and 68.4% had high-risk HPV infections. Patients with 25 hydroxyvitamin D levels <20 ng/ml had a higher prevalence of cervical HPV infection than those with levels ≥20 ng/ml (30.7% vs. 25.8%; p = 0.72). We found no significant difference when high-risk HPV infection was evaluated (36.8% vs. 31.5%; p = 0.73). In conclusion, women with SLE have a high prevalence of vitamin D deficiency and cervical HPV infection. However, we found no association between vitamin D deficiency and cervical HPV.

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Section: Discussioncontrasting

confidence: 73%

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

Garcı́a-Carrasco

Munguía‐Realpozo²,

Rodríguez-Gallegos

et al. 2014

Lupus

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“…Growing evidence further documents a role for vitamin D in reducing risk of chronic diseases including some cancers [2–5], type 1 [6, 7] and type 2 diabetes mellitus [8], and multiple sclerosis [9, 10] Vitamin D may also be protective against cardiovascular disease [CVD] [1, 11–13] myocardial dysfunction [14], and hypertension in middle-aged and older women [15]. In children, vitamin D is especially important because of its vital role in bone mineralization [16, 17], insulin sensitivity in obese children and adolescents [18], and cardiac health [19].…”

Section: Introductionmentioning

confidence: 99%

Ethnic differences in food sources of vitamin D in adolescent American girls: the National Heart, Lung, and Blood Institute Growth and Health Study

et al. 2011

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The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) was a 10-year longitudinal study of the development of obesity and CVD risk factors (including dietary, psychosocial, environmental and others) in 2,379 African-American and white females who were 9 or 10 years old at study entry. Current studies have documented a high prevalence of vitamin D insufficiency among healthy children, adolescents and young adults in the United States, especially among low-income, black and Hispanic children (defined as serum 25-hydroxyvitamin D concentrations of ≤ 20 ng/mL). Although the main source of vitamin D is direct exposure of the skin to ultraviolet rays from sunlight, certain foods contribute vitamin D including fortified milk, meat, eggs, oils and fortified cereals. Vulnerable subgroups that are especially at risk of inadequate intakes of vitamin D, include teenage girls and women. Research providing the prevalent food sources of vitamin D, especially in the diets of both white and African American female adolescents is limited. The purpose of this study is to document food sources of vitamin D reported by this biracial young cohort and compare potential ethnic or other differences that could enhance tailored dietary interventions that are particularly relevant to this vulnerable population subgroup.

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“…[6][7][8] [10][11][12][13][14][15] Several VDR single nucleotide polymorphisms have been described 6,16 ; although most studies found no associations between these VDR single nucleotide polymorphisms and prostate cancer risk, [16][17][18][19] two studies found that men with low 25(OH)D levels and the BsmI BB allele had a lower risk of prostate cancer. 18,19 Men with low 25(OH)D levels and the less functional FokI f allele had an almost two-fold increase in risk for total prostate cancer compared with men with the FokI FF/Ff allele and high 25(OH)D levels; the association was even stronger for advanced-stage or high-grade disease.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Protein Expression in Tumor Tissue and Prostate Cancer Progression

Hendrickson

Flavin

Kasperzyk

et al. 2011

JCO

131

120

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PurposeData suggest that circulating 25-hydroxyvitamin D [25(OH)D] interacts with the vitamin D receptor (VDR) to decrease proliferation and increase apoptosis for some malignancies, although evidence for prostate cancer is less clear. How VDR expression in tumor tissue may influence prostate cancer progression has not been evaluated in large studies.Patients and MethodsWe examined protein expression of VDR in tumor tissue among 841 patients with prostate cancer in relation to risk of lethal prostate cancer within two prospective cohorts, the Physicians' Health Study and Health Professionals Follow-Up Study. We also examined the association of VDR expression with prediagnostic circulating 25(OH)D and 1,25-dihydroxyvitamin D levels and with two VDR single nucleotide polymorphisms, FokI and BsmI.ResultsMen whose tumors had high VDR expression had significantly lower prostate-specific antigen (PSA) at diagnosis (P for trend < .001), lower Gleason score (P for trend < .001), and less advanced tumor stage (P for trend < .001) and were more likely to have tumors harboring the TMPRSS2:ERG fusion (P for trend = .009). Compared with the lowest quartile, men whose tumors had the highest VDR expression had significantly reduced risk of lethal prostate cancer (hazard ratio [HR], 0.17; 95% CI, 0.07 to 0.41). This association was only slightly attenuated after adjustment for Gleason score and PSA at diagnosis (HR, 0.33; 95% CI, 0.13 to 0.83) or, additionally, for tumor stage (HR, 0.37; 95% CI, 0.14 to 0.94). Neither prediagnostic plasma vitamin D levels nor VDR polymorphisms were associated with VDR expression.ConclusionHigh VDR expression in prostate tumors is associated with a reduced risk of lethal cancer, suggesting a role of the vitamin D pathway in prostate cancer progression.

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The beneficial role of vitamin D and its analogs in cancer treatment and prevention

Cited by 32 publications

References 112 publications

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

Lack of association between serum 25-hydroxyvitamin D levels and cervical human papillomavirus infection in systemic lupus erythematosus

Ethnic differences in food sources of vitamin D in adolescent American girls: the National Heart, Lung, and Blood Institute Growth and Health Study

Vitamin D Receptor Protein Expression in Tumor Tissue and Prostate Cancer Progression

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