The beneficial effects of tetracosanol on insulin-resistance by insulin receptor kinase sensibilisation

Hsu, Chia‐Yu; Shih, Hung-Yuan; Chang, Ying; Huang, Zehao; Tsai, Ming-Tzu; Chia, Yi‐Chen; Chen, C.; Lai, Yiu Kay; Weng, Ching‐Feng

doi:10.1016/j.jff.2015.01.033

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…The majority of insulin-mediated glucose disposal is found in skeletal muscles. Insulin resistance and impaired insulin secretion are attributed to impaired insulin signaling pathway [29,30]. Therefore, in this study, we have investigated whether BC administration improves impaired insulin signaling pathway in muscles of STZ induced diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

2018

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The goal of the present study was to evaluate the effect of Berberine chloride (BC) on lipid profile, oxidant status and insulin signaling molecules in Streptozotocin (STZ) induced diabetic rat model. Diabetes was induced in rats by a single dose of intraperitoneal administration of STZ (40 mg/kg b.w). Diabetic rats were treated with BC (50 mg/kg b.w) and glibenclamide (6 mg/kg b.w) for 45 days. BC treated diabetic rats showed significant (p \0.05) decrease in the levels of TC, TG, phospholipids, LDL, VLDL and lipid peroxidation markers such as LOOH and TBARS. An increase in enzymatic antioxidant (SOD, CAT and GPx), non-enzymatic antioxidant (GSH, vitamin C and E) and insulin signaling molecules expression, like Insulin receptor substrate-1 (IRS-1), Protein kinase B (PKB or Akt) and glucose transporter-4 (GLUT-4) were found to be significantly raised in BC treated STZ induced diabetic rats. Thus, the results of the current study demonstrated that BC significantly reversed the abnormal levels of lipids, oxidant status and insulin signaling molecules in the diabetic rat model, which may be contributed to its anti-diabetic and antioxidant activities.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

2018

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“…extrapolate the health effects of the policosanols mentioned above to those in oil from Cf. However, Hsu et al (2015) found that chain length of the policosanols did not affect their impact on glycemic control. Thus, it might be that the fatty alcohols found in calanus oil have similar effects as the policosanols.…”

Section: Fatty Alcoholsmentioning

confidence: 90%

“…It is therefore difficult to extrapolate the health effects of the policosanols mentioned above to those in oil from Cf . However, Hsu et al. (2015) found that chain length of the policosanols did not affect their impact on glycemic control.…”

Section: The Main Components Of the Oil From Cf Anmentioning

confidence: 90%

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Possible Health Effects of a Wax Ester Rich Marine Oil

et al. 2020

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The consumption of seafood and the use of fish oil for the production of nutraceuticals and fish feed have increased over the past decades due the high content of long-chain polyunsaturated omega-3 fatty acids. This increase has put pressure on the sustainability of fisheries. One way to overcome the limited supply of fish oil is to harvest lower in the marine food web. Calanus finmarchicus, feeding on phytoplankton, is a small copepod constituting a considerable biomass in the North Atlantic and is a novel source of omega-3 fatty acids. The oil is, however, different from other commercial marine oils in terms of chemistry and, possibly, bioactivity since it contains wax esters. Wax esters are fatty acids that are esterified with alcohols. In addition to the long-chain polyunsaturated omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the oil is also rich in stearidonic acid (SDA), long-chain monounsaturated fatty acids, and the long-chain fatty alcohols eicosenol and docosenol. Recent animal studies have indicated antiinflammatory and anti-obesogenic actions of this copepod oil beyond that provided by EPA and DHA. This review will discuss potential mechanisms behind these beneficial effects of the oil, focusing on the impact of the various components of the oil. The health effects of EPA and DHA are well recognized, whereas long-chain monounsaturated fatty acids and long-chain fatty alcohols have to a large degree been overlooked in relation to human health. Recently, however the fatty alcohols have received interest as potential targets for improved health via conversion to their corresponding fatty acids. Together, the different lipid components of the oil from C. finmarchicus may have potential as nutraceuticals for reducing obesity and obesity-related metabolic disorders.

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“…Tetracosanol could also improve glycemic control via an effect on insulin receptor kinase activity that leads to glucose transporter translocation and improve glucose uptake. The insulin receptor kinase activity was also ascribed to the hydroxyl group [14]. In a previous work, when analyzing rice bran oil, that demonstrated multiple health benefits, the main aliphatic alcohol in policosanol was tetracosanol, followed by hexacosanol then octacosanol while heptacosanol showed the lowest level [6,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Potential anti-dyslipidemia and hepatoprotection of functional food ‎components represented by tetracosanol and mixture of policosanol in Triton ‎X-100 induced dyslipidemic rats ‎

Al‐Okbi

Al-Siedy

2022

Egypt. J. Chem.

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The elevated plasma triglycerides (TGs), total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) with concomitant reduction of high density lipoprotein-cholesterol (HDL-C) are designated as dyslipidemia. The aim of the present research was to study the protective effect of tetracosanol and policosanol mixture towards triton X-100 induced dyslipidemia along with their hepatoprotective effect in rats. The policosanol mixture was prepared from tetracosanol, hexacosanol, octacosanol and heptacosanol in the ratio of 3:1:1:1. Rats were divided into 4 groups; a normal control (NC), dyslipidemic control (DC) and two test groups with dyslipidemia and treated with either tetracosanol or policosanol mixture in the form of emulsions. The determined biochemical parameters were plasma TGs, TC, LDL-C, HDL-C, malondialdehyde (MDA) and the activities of alanine transaminase (ALT) and aspartate transaminase (AST). In addition to calculation of TC/HDL-C and LDL-C/HDL-C as the elevation of such ratios are considered risk factors for cardiovascular diseases (CVDs). Histopathological examination of liver was also carried out. Results showed significant dyslipidemia and elevated LDL-C/HDL-C, TC/HDL-C, MDA, ALT and AST with liver histopatological changes in the DC group compared to the NC group. Both tetracosanol and policosanol mixture reduced the risk factors for CVDs and improved the dyslipidemia, oxidative stress and liver function. Tetracosanol was superior in reducing TC, ALT and AST and improving liver histopathology while policosanol mixture was more efficient in reducing oxidative stress.

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The beneficial effects of tetracosanol on insulin-resistance by insulin receptor kinase sensibilisation

Cited by 7 publications

References 33 publications

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

Possible Health Effects of a Wax Ester Rich Marine Oil

Potential anti-dyslipidemia and hepatoprotection of functional food ‎components represented by tetracosanol and mixture of policosanol in Triton ‎X-100 induced dyslipidemic rats ‎

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