RETRACTED ARTICLE: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats

Abstract

The goal of the present study was to evaluate the effect of Berberine chloride (BC) on lipid profile, oxidant status and insulin signaling molecules in Streptozotocin (STZ) induced diabetic rat model. Diabetes was induced in rats by a single dose of intraperitoneal administration of STZ (40 mg/kg b.w). Diabetic rats were treated with BC (50 mg/kg b.w) and glibenclamide (6 mg/kg b.w) for 45 days. BC treated diabetic rats showed significant (p \0.05) decrease in the levels of TC, TG, phospholipids, LDL, VLDL and lipid peroxidation markers such as LOOH and TBARS. An increase in enzymatic antioxidant (SOD, CAT and GPx), non-enzymatic antioxidant (GSH, vitamin C and E) and insulin signaling molecules expression, like Insulin receptor substrate-1 (IRS-1), Protein kinase B (PKB or Akt) and glucose transporter-4 (GLUT-4) were found to be significantly raised in BC treated STZ induced diabetic rats. Thus, the results of the current study demonstrated that BC significantly reversed the abnormal levels of lipids, oxidant status and insulin signaling molecules in the diabetic rat model, which may be contributed to its anti-diabetic and antioxidant activities.

Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway

“…Simultaneously, as a cause and result of other factors, hyperglycemia is a key mediating factor in the complex etiologic network of DM‐OS 11 . Extensive evidence 26–31 has suggested that BBR regulates glucose metabolism via various mechanisms, such as, stimulating glucagon‐like protein‐1‐dependent insulin secretion, improving insulin resistance by protein kinase C‐mediated upregulation of insulin receptor expression and activation of the IRS‐1 signaling cascade, promoting adenosine monophosphate‐activated protein kinase (AMPK)‐initiated glycolysis, facilitating glucose uptake in adipose tissue by stimulating glucose transporter 1 expression, and inhibiting gluconeogenesis in the liver. In this study, the improved glucose metabolism by BBR treatment hinted that BBR is a potential agent for addressing the adverse effect of hyperglycemia on bone.…”

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

“…BBR caused the glucose metabolism modulation by the GnRH-GLP-1 and MAPK pathway in the gut (Zhang et al, 2014). The treatment of BBR chloride notably protected the blood components (Chandirasegaran et al, 2017) and significantly reversed the abnormal levels of lipids, oxidant status, and insulin signaling molecules in the diabetic rat model (Chandirasegaran et al, 2019). BBR also reduced the release of lipopolysaccharides and ameliorated inflammation by reducing the level of lipolysaccharide binding protein (LBP), thus alleviating intestinal injury and improving InsR (Cui et al, 2018).…”

Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study

“…Berberine is a hydroxyl radical scavenger, and its main metabolite—berberrubine—reveals even greater antioxidative activity than berberine [ 28 ]. It has been reported that after treatment with berberine, the levels of the oxidative stress-related markers decreased while the levels of endogenous antioxidants increased in the tissues of laboratory animals [ 29 , 30 , 31 ].…”