The beneficial effects of physical activity and weight loss on human colorectal carcinoma cell lines

Introduction Various surgical societies constantly update their recommendations in order to adapt surgical activity on current Pandemic conditions. The aim of this study is to analyze how hospitalizations and emergency operations have changed in our Department of Medical and Surgical Sciences in the Hospital of Foggia during covid-19 pandemic. Methods Our cohort-study was conducted by analyzing two groups of patients admitted to the Department of Medical and Surgical Sciences of the Hospital of Foggia: those admitted during the no-covid period from March 09th, 2019 to May 09th, 2019 and those during the covid period from March 09th, 2020 to May 09th, 2020. Results A total of 750 patients admitted during the no-covid period of 2019 and 171 during the covid period of 2020, of these 222 were emergency admission during 2019 and 97 during 2020, 528 were elective admission during 2019 and 74 during 2020. Of the emergency admissions (222 during 2019 and 97 during 2020), 91 were operated during the no covid period in 2019 and 52 during the covid period in 2020. The mean Mannheim Peritonitis Index Score, that is a scoring system used in peritonitis which is simple and cost-effective, were 15.6 during the no covid period of 2019 and 22.2 during the covid period of 2020. We observed 29 post-operative complications during 2019 and 26 during 2020. Conclusions Contraction of admissions for urgent and emergent conditions in the first period of lockdown has been followed from some positive effects as well as aggravating consequences.

show abstract

“…The rapidly spreading outbreaks imposes an unprecedented burden of the effectiveness and sustainability of our healthcare system [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

How emergency surgery has changed during the COVID-19 pandemic: A cohort study

Tartaglia

Pavone

Lizzi

et al. 2020

Annals of Medicine and Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is a crucial point of neuroimmunology because it demonstrates that a molecule secreted by the immune system can induce neuronal sensitization and consequently proves that an antagonist of the receptor can inhibit the hyperalgesic effect [ 120 ]. The role of cytokines in pain modulation has been demonstrated in the treatment of several diseases, including arthritis, neuropathic pain, and cancer-related pain [ 121 , 122 ]. The role of IL-1β, IL-6, tumor necrosis factor alpha, IL-17A, and interleukin-5, which act directly on nociceptor neurons, has been demonstrated.…”

Section: Cytokines Involved In Painmentioning

confidence: 99%

Mechanisms of Transmission and Processing of Pain: A Narrative Review

Maio

Villano

Ilardi

et al. 2023

IJERPH

Self Cite

View full text Add to dashboard Cite

Knowledge about the mechanisms of transmission and the processing of nociceptive information, both in healthy and pathological states, has greatly expanded in recent years. This rapid progress is due to a multidisciplinary approach involving the simultaneous use of different branches of study, such as systems neurobiology, behavioral analysis, genetics, and cell and molecular techniques. This narrative review aims to clarify the mechanisms of transmission and the processing of pain while also taking into account the characteristics and properties of nociceptors and how the immune system influences pain perception. Moreover, several important aspects of this crucial theme of human life will be discussed. Nociceptor neurons and the immune system play a key role in pain and inflammation. The interactions between the immune system and nociceptors occur within peripheral sites of injury and the central nervous system. The modulation of nociceptor activity or chemical mediators may provide promising novel approaches to the treatment of pain and chronic inflammatory disease. The sensory nervous system is fundamental in the modulation of the host’s protective response, and understanding its interactions is pivotal in the process of revealing new strategies for the treatment of pain.

show abstract

“…As previously reported the physical activity program consist in the mixed exercise program (Polito et al 2020). The protocol consist in 90 minutes per week in 2 session for 6 months.…”

Section: Physical Activity Protocolmentioning

confidence: 99%

Physical activity has numerous beneficial effects on metabolic and inflammatory processes

Polito¹,

Monda²,

Ametta³

et al. 2020

Journal of Human Sport and Exercise - 2020 - Spring Conferences of Sports Science

Self Cite

View full text Add to dashboard Cite

Obesity is a long-term multifactorial chronic disease, characterized by energy imbalance, due to an excess of caloric intake compared to energy expenditure and deregulation of other metabolic parameters, as, altered lipid profile, increased insulin resistance and chronic pro-inflammatory state. A healthy lifestyle, characterized by hypocaloric diet and physical activity, is important to reduce a chronic inflammation, oxidative stress and metabolic disorders typical of obesity. It is well known that the chronic inflammation state and oxidative stress are responsible for the aging and development of many diseases, such as cancer. In the light of these evidences, the aim of this study is to analyse body composition, metabolic profile and oxidative stress levels in obese patients subjected to a physical activity program before and after weight loss. We analysed the glycaemic and lipid profile, body composition such as visceral adipose tissue (VAT), fat mass (FM), and the dROMs serum levels via the Fenton's reaction. We found that in obese patients before physical activity intervention there are higher levels in dROMs serum levels, altered glycaemic and lipid profile and body composition compared to obese patients after physical activity intervention. In conclusion, the physical activity has numerous beneficial effects in obesity, modulating not only metabolic profile but also inflammatory and oxidative stress response.

show abstract

The beneficial effects of physical activity and weight loss on human colorectal carcinoma cell lines

Cited by 11 publications

References 26 publications

How emergency surgery has changed during the COVID-19 pandemic: A cohort study

How emergency surgery has changed during the COVID-19 pandemic: A cohort study

Mechanisms of Transmission and Processing of Pain: A Narrative Review

Physical activity has numerous beneficial effects on metabolic and inflammatory processes

Contact Info

Product

Resources

About