The Beneficial Effects of Agomelatine in Experimental Model of Sepsis Related Acute Kidney Injury

Başol, Nurşah; Erbaş, Oytun; Çavuşoğlu, Türker; Meral, Ayfer; Ateş, Utku

doi:10.5505/tjtes.2015.29499

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…These fi ndings are in accordance with several other types of research, which reported that AGO decreased in BUN and creatinine in sepsis-related acute kidney injury by reducing oxidative stress (37). The nephrotoxicity of ADR, also including sepsis-related acute kidney injury, is related to the oxidative stress in kidney (6,35,37). A relationship between oxidative stress and nephrotoxicity has been confi rmed in many experimental models (8,38,39).…”

Section: Discussionsupporting

confidence: 89%

“…Agomelatine is a melatonin receptor agonist (M1/M2) and serotonin receptor antagonist (5 HT-2C), known to be more potent than melatonin receptor (36). These fi ndings are in accordance with several other types of research, which reported that AGO decreased in BUN and creatinine in sepsis-related acute kidney injury by reducing oxidative stress (37). The nephrotoxicity of ADR, also including sepsis-related acute kidney injury, is related to the oxidative stress in kidney (6,35,37).…”

Section: Discussionsupporting

confidence: 85%

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Protective effect of melatonin and agomelatine on adriamycin-induced nephrotoxicity in rat model: a renal scintigraphy and biochemical study

Aygün¹,

Gül²

2019

BLL

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OBJECTIVE: We aimed to determine the possible protective effects of melatonin and agomelatine on an animal model of adriamycin nephrotoxicity by 99m Tc DMSA renal scintigraphy and biochemical methods. METHODS: Ten weeks old 49 male Wistar rats were randomly separated into seven groups; namely control (CON), adriamycin (ADR), melatonin (MEL), agomelatine (AGO), melatonin + adriamycin (MEL+ADR), agomelatine + adriamycin (AGO+ADR) and melatonin + agomelatine + adriamycin (MEL+AGO+ADR) groups. Nephrotoxicity was induced by a three-dose of 18 mg/kg adriamycin, i.p. at a 24 h interval on the 5th, 6th and 7th days. A dose of melatonin and agomelatine (40 mg/kg/i.p, the same doses) were injected for 7 days before and after the injected of ADR (18 mg/kg, i.p.), respectively. On the 8th day of the experiment, all animals were evaluated and scintigraphic and biochemical parameters were assessed, respectively. RESULTS: ADR signifi cantly increased blood urea nitrogen (1040 %) and plasma creatinine (1020 %), and decreased 99m Tc DMSA uptake levels (59 %) compared to the control (p < 0.001). Pretreatment with MEL, AGO, MEL+AGO mitigated these abnormalities produced by ADR in the kidney (p < 0.001). CONCLUSION: 99m Tc DMSA for the early determination of ADR-induced nephrotoxicity had an important role. Also, a signifi cant correlation was found between biochemical and scintigraphy parameters. Adriamycin caused signifi cant damages to kidneys that were reduced with MEL and AGO (Tab. 2, Fig. 3, Ref. 39).

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

Protective effect of melatonin and agomelatine on adriamycin-induced nephrotoxicity in rat model: a renal scintigraphy and biochemical study

Aygün¹,

Gül²

2019

BLL

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“…Increases in MDA and MPO values, a decrease in GSH values, and an increase in apoptosis were observed in the kidney, and histological examination showed renal tissue damage. [28][29][30][31][32][33][34] Similar findings were obtained in the sepsis model applied in our study. It was determined that there was no significant difference in the serum creatinine value between the groups, but a significant increase was noted in the CLP group after 72 hours.…”

Section: Discussionsupporting

confidence: 89%

Effects of Dapagliflozin on Experimental Sepsis Model in Rats

Kıngır¹

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: The aim of this study was to evaluate the possible protective effects of dapagliflozin in an experimental sepsis model in rats. METHODS: Saline (1 mL/kg, p.o.) or dapagliflozin (10 mg/kg, p.o.) was administered to Sprague-Dawley rats for 5 days prior to the surgical procedures. Under anesthesia, sepsis was induced by cecal ligation puncture, while sham control groups underwent laparotomy only. Blood urea nitrogen, creatinine, and glucose levels were measured in serum samples and the levels of malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor alpha, interleukin 1 beta, caspase 8, and caspase 9 were determined in tissue samples (kidney, liver, and lung). Histological evaluation was also performed. RESULTS: The administration of dapagliflozin in a sepsis model reduced oxidative stress (MDA), increased antioxidant levels (GSH), and reduced inflammation (MPO) in the kidney (p<0.05). Dapagliflozin also decreased oxidative stress (MDA) in lung tissue and decreased inflammation (MPO) in lung and liver tissue (p<0.05). Caspase 8 and 9 levels in kidney, lung, and liver tissue were increased (p<0.05) in the dapagliflozin group compared with the sepsis group. According to the histopathological results, sepsis was moderately improved in renal tissue and slightly attenuated in lung and liver tissue with the administration of dapagliflozin. CONCLUSION: Dapagliflozin had a preventive effect on sepsis-induced kidney damage, but the protective effect was mild in lung and liver tissue in the present study.

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“…Furthermore, substantial evidence suggests that the mortality rate among patients diagnosed with AKI, particularly those necessitating dialysis interventions, can exceed 70% (ref. 28,29 ). Furthermore, Medieros et al provide a description indicating that Tibolone and 17-estradiol exhibit effective augmentation of plasma atrial natriuretic peptide (ANP) levels and ANP messenger RNA (mRNA) levels in the left atrium 30 .…”

Section: Discussionmentioning

confidence: 99%

The renoprotective effect of Tibolone in sepsis-induced acute kidney injury

Bora,

Arda,

Erbaş

2024

BIOMED PAP

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Introduction. Sepsis-induced acute kidney injury (AKI) remains a major challenge in intensive care, contributing significantly to morbidity and mortality. Tibolone, known for its neuroprotective and hormonal properties, has not been explored for its potential in AKI management. This study investigates the protective effects of Tibolone and its underlying mechanisms involving Sirtuin-1 (SIRT1) and Yes-Associated Protein (YAP) in a rat sepsis model. Materials and Methods. Thirty-six female Wistar albino rats underwent cecal ligation and puncture (CLP) to induce sepsis. They were randomly assigned to control, CLP+Saline, and CLP+Tibolone groups. Tibolone was administered intraperitoneally. Biomarkers, including Sirtuin (SIRT1), Yes-associated protein (YAP), Tumor necrosis factor (TNF-α), High mobility group box 1 (HMGB1), malondialdehyde (MDA), creatinine, and urea, were assessed. Histopathological examination evaluated renal damage. Results. Tibolone administration significantly reduced plasma TNF-α, HMGB1, MDA, creatinine, and urea levels compared to the CLP+Saline group. Moreover, Tibolone elevated SIRT1 and YAP levels in kidney tissues. Histopathological examination demonstrated a significant decrease in tubular epithelial necrosis, luminal debris, dilatation, hemorrhage, and interstitial inflammation in Tibolone-treated rats. Conclusion. This study unveils the protective role of Tibolone against sepsis-induced AKI in rats. The improvements in inflammatory and oxidative biomarkers and histological evidence suggest Tibolone's potential as a therapeutic intervention in sepsis-associated kidney injury. The upregulation of SIRT1 and YAP indicates their involvement in Tibolone's renoprotective mechanisms. Further investigations are warranted to explore Tibolone's translational potential in human sepsis-induced AKI.

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The Beneficial Effects of Agomelatine in Experimental Model of Sepsis Related Acute Kidney Injury

Cited by 8 publications

References 29 publications

Protective effect of melatonin and agomelatine on adriamycin-induced nephrotoxicity in rat model: a renal scintigraphy and biochemical study

Protective effect of melatonin and agomelatine on adriamycin-induced nephrotoxicity in rat model: a renal scintigraphy and biochemical study

Effects of Dapagliflozin on Experimental Sepsis Model in Rats

The renoprotective effect of Tibolone in sepsis-induced acute kidney injury

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