The renoprotective effect of Tibolone in sepsis-induced acute kidney injury
Ejder Saylav Bora,
Duygu Burcu Arda,
Oytun Erbaş
Abstract:Introduction. Sepsis-induced acute kidney injury (AKI) remains a major challenge in intensive care, contributing significantly to morbidity and mortality. Tibolone, known for its neuroprotective and hormonal properties, has not been explored for its potential in AKI management. This study investigates the protective effects of Tibolone and its underlying mechanisms involving Sirtuin-1 (SIRT1) and Yes-Associated Protein (YAP) in a rat sepsis model. Materials and Methods. Thirty-six female Wistar albino rats und… Show more
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