The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer

Herszényi, László; Hritz, István; Lakatos, Gábor; Varga, Mária Zsófia; Tulassay, Zsolt

doi:10.3390/ijms131013240

Cited by 138 publications

(143 citation statements)

References 163 publications

(140 reference statements)

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“…Additionally, the impact of TIMPs is fundamental to the homeostasis of the ECM, because of TIMPs' ability to control the interaction of cells via adhesion and signaling molecules such as growth factors. The significance of TIMPs as signaling molecules in their own right is only just beginning to be reported [9,33].…”

Section: The Regulation Of Mmpsmentioning

confidence: 99%

“…A disruption of the balance between the concentration of active metalloproteinases and their inhibitors may lead to pathological changes associated with uncontrolled ECM turnover, tissue remodeling, inflammatory response, cell growth and migration [3,9,30]. Additionally, the impact of TIMPs is fundamental to the homeostasis of the ECM, because of TIMPs' ability to control the interaction of cells via adhesion and signaling molecules such as growth factors.…”

Section: The Regulation Of Mmpsmentioning

confidence: 99%

“…However, the overexpression of several MMPs is involved in tumor invasion, metastasis, disregulated angiogenesis, inflammation and even cell destruction [1,[5][6][7][8][9]. …”

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confidence: 99%

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The Significance of Matrix Metalloproteinases in Oral Diseases

et al. 2015

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MMPs are significant in the physiological processes of embryo development, wound healing and differentiation related to tissue remodeling. However, the overexpression of several MMPs is involved in tumor invasion, metastasis, disregulated angiogenesis, inflammation and even cell destruction [1,[5][6][7][8][9]. MMP SubfamiliesThe first metalloproteinase was discovered in 1962 during a study of the ECM degradation re- The Role of MMPsMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. These activities are implicated in a number of essential physiopathological processes AbstractMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. Disruption of the balance between the concentration of active matalloproteinases and their inhibitors (TIMPs) may lead to pathological changes associated with uncontrolled ECM turnover, tissue remodeling, inflammatory response, cell growth and migration. This brief review presents some information on MMPs' role in inflammatory, metabolic and cancer abnormalities related to the salivary glands, as well as MMP-related aspects that lead to the formation of human dentinal caries lesions. In oral diseases, the most relevant biological fluid commonly used for diagnosing periodontal diseases is saliva. In diseased patients with significantly higher levels of MMPs in their saliva than healthy people, most extracellular matrix components undergo digestion to lower molecular weight forms. Conventional treatment successfully reduces the levels of MMPs inhibits the progressive breakdown of gingival and periodontal ligament collagens. Beside inflammatory abnormalities like Sjögren's syndrome (SS), a large group of disorders is comprised of cancers, most of them involving the parotid gland (Adv Clin Exp Med 2016, 25, 2, 383-390).

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Section: The Regulation Of Mmpsmentioning

confidence: 99%

Section: The Regulation Of Mmpsmentioning

confidence: 99%

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The Significance of Matrix Metalloproteinases in Oral Diseases

et al. 2015

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“…VEGF could induce endothelial cells to secrete cathepsin, including metal matrix protein enzymes, leading to degradate ECM and mediate endothelial cell migration. In addition, MMP-2 can not only degradate ECM, but also accelerate the growth of vascular endothelial cells from gap to the outside to gradually extend vascular bud in the process of new blood vessels (Herszenyi et al, 2012). Thus, metal matrix protein enzymes can promote the expression of VEGF and the formation of tumor blood vessels to promote the invasiveness of tumor cells.…”

Section: Fnc Inhibition Of Non-hodgkin Lymphoma Cell Invasion Via Thementioning

confidence: 99%

FNC, a Novel Nucleoside Analogue, Blocks Invasion of Aggressive Non-Hodgkin Lymphoma Cell Lines Via Inhibition of the Wnt/β-Catenin Signaling Pathway

Zhang

Wang²,

Ding³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Chemotherapy is the primary therapy for malignant lymphoma (ML). However, the clinical outcome is still far from satisfactory. Consequently, an understanding of the mechanism of modulating cancer cell invasion, migration and metastasis is important for the development of more effective chemotherapeutic agents. FNC, 2'-deoxy-2' -β-fluoro -4'-azidocytidine, a novel cytidine analogue, has demonstrated significantly inhibitory effects on proliferation of several non-Hodgkin lymphoma (NHL) cell lines. A previous study indicated that FNC effectively inhibited the growth of Raji and JeKo-1 cells in dose-time dependent effects with IC 50 values of 0.2μM and 0.097μM, respectively. This study was focused on investigating the anti-invasive properties of FNC on NHL cells and its potential mechanisms of action. Cell adhesion and transwell chamber assays were utilized to investigate the anti-invasive effects of FNC on Raji and JeKo-1 cells. Real-time PCR and Western blotting were employed to qualify the expression of β-catenin, the glycogen synthase kinase-3 beta (GSK-3β), E-cadherin vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The results revealed that FNC remarkably inhibited the adhesion, migration and invasion of two human aggressive non-Hodgkin lymphoma cell lines in a dose dependent manner. Furthermore, β-catenin, MMP-2, MMP-9, VEGF mRNA and protein levels were decreased after FNC treatment, while GSK-3β and E-cadherin increased. Our studies thus provide evidence and a rationale that FNC may offer an effective chemotherapeutic agent by regulating the invasion and metastasis of aggressive non-Hodgkin lymphoma via inhibition of the Wnt/β-catenin signaling pathway.

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“…Thus, it is well established the implication of MMPs in cancer development [33], such as breast cancer [34], colorectal cancer [35,36], prostate cancer [37] and hepatocellular carcinoma [38] among others.…”

Section: Mmps and Timps In Disease And Cancermentioning

confidence: 99%

Clinical Relevance of Matrix Metalloproteases and their Inhibitors in Breast Cancer

2013

J Carcinog Mutagen

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Degradation of the stromal connective tissue and basement membrane components are key elements in tumor invasion and metastasis. Some components, particularly the interstitial collagens, are very resistant to proteolytic attacks and can be degraded by specific proteinases like Matrix Metalloproteinases (MMPs). MMPs can also impact on tumor cell behavior in vivo as a consequence of their ability to cleave growth factors, cell surface receptors, cell adhesion molecules, or chemokines/cytokines, and for stimulating angiogenesis. Different molecular expression profiles of MMPs and their inhibitors (TIMPs) have been associated with the main steps in breast cancer progression, such as creating a potential invasive phenotype in Ductal Carcinoma in situ (DCIS), favoring the hematogenous dissemination, and enabling the metastatic progression across the axillary lymphatic system. These associations have clinical interests, as they can contribute to a better characterization of early breast carcinomas (which differ in their both biological and clinical behavior), evaluate microinvasion in resection specimens of breast tumors, provide a more precise prognostic, and predict the tumoral status of non-sentinel lymph nodes in breast cancer. It is also especially remarkable the evidences indicating that MMPs and TIMPs expression in individual cell populations from tumor stroma, such as mononuclear inflammatory cells (MICs) and fibroblast, clearly impacts on the clinical outcome of breast cancer patients. There are several factors linking inflammation, MMP activity and breast cancer. This knowledge will be useful to develop novel therapies and prevention strategies targeting critical components.

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The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer

Cited by 138 publications

References 163 publications

The Significance of Matrix Metalloproteinases in Oral Diseases

The Significance of Matrix Metalloproteinases in Oral Diseases

FNC, a Novel Nucleoside Analogue, Blocks Invasion of Aggressive Non-Hodgkin Lymphoma Cell Lines Via Inhibition of the Wnt/β-Catenin Signaling Pathway

Clinical Relevance of Matrix Metalloproteases and their Inhibitors in Breast Cancer

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