The behavior of amphotericin B monolayers at the air/water interface

Seoane, J. R.; Romeu, Nuria Vila; Miñones, J.; Conde, O.; Dynarowicz, Patrycja; Casas, M.

doi:10.1007/bfb0110983

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…closer to the jamming point where it is marginally stable and closer to the dynamical transition. Establishing whether three dimensional thermal glasses display a Gardner transition (or at least a remnant of it) is a crucial open issue [54,61]. Hopefully, our results will be useful guidelines for this line of research.…”

Section: Discussionmentioning

confidence: 95%

Liu-Nagel phase diagrams in infinite dimension

Biroli

Urbani

2018

SciPost Phys.

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We study Harmonic Soft Spheres as a model of thermal structural glasses in the limit of infinite dimensions. We show that cooling, compressing and shearing a glass lead to a Gardner transition and, hence, to a marginally stable amorphous solid as found for Hard Spheres systems. A general outcome of our results is that a reduced stability of the glass favors the appearance of the Gardner transition. Therefore using strong perturbations, e.g. shear and compression, on standard glasses or using weak perturbations on weakly stable glasses, e.g. the ones prepared close to the jamming point, are the generic ways to induce a Gardner transition. The formalism that we discuss allows to study general perturbations, including strain deformations that are important to study soft glassy rheology at the mean field level. I. INTRODUCTIONWhen a liquid is cooled fast enough in such a way that crystallization is avoided, it enters in a supercooled phase where upon further decreasing the temperature it freezes in an amorphous solid phase, a glass [1]. This phenomenon has been investigated since the works by Adam and Gibbs [2] that were aimed to clarify the thermodynamical nature of the glass transition. Starting from the pioneering works by Kirkpatrick, Thirumalai and Wolynes [3][4][5][6], physicists have realized that there exists a deep connection between the Adam-Gibbs picture of the glass formation and the statistical physics of disordered systems such as spin glasses. The works of Franz, Parisi, Mézard and Monasson [7-15] showed how to adapt the replica method, a very powerful tool to study the properties of system with quenched disorder, to disorder-free Hamiltonians. This stream of ideas led finally to the exact description of the amorphous phases of hard spheres in the limit of infinite dimensions [16,17]. Hard sphere systems are good theoretical models of colloidal glasses and have been studied in recent years to understand the critical properties of the jamming transition. Remarkably, the mean field theory of hard sphere glasses is able to correctly describe the criticality of jammed packings in three dimensions giving a very accurate prediction of the critical exponents that appear at the jamming point. Furthermore, the infinite dimensional solution of the hard sphere model has suggested that colloidal glasses at very high pressure could undergo a new phase transition, the Gardner transition, that was firstly found in models of spin glasses [18][19][20][21] and whose consequence in the structural glass case are the object of a very intense research activity [22][23][24][25][26]. Beyond the Gardner point, hard sphere glasses are predicted to be marginally stable: their properties are deeply affected by non-trivial soft modes that drive strong non-linear elastic responses [25,[27][28][29][30][31][32][33][34][35][36]. The aim of the present work is to extend the analysis done for hard spheres to thermal glasses. We shall present the phase diagram for elastic spheres in infinite dimensions and thoroughly study the properties...

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Section: Discussionmentioning

confidence: 95%

Liu-Nagel phase diagrams in infinite dimension

Biroli

Urbani

2018

SciPost Phys.

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“…It has been supposed [22,47] that in the liquid-expanded region, molecules are lying flat on the surface (with the limiting area of ca. 180 2 2 /molecule as calculated from molecular models), linked to the surface water by hydrogen bonds, whereas in the liquid-condensed region, the molecules are oriented vertically (with the area of 55 2 2 / molecule), and most of the hydrogen bonds are broken.…”

Section: Monolayers Formed By Pure Mf-amementioning

confidence: 99%

“…180 2 2 /molecule as calculated from molecular models), linked to the surface water by hydrogen bonds, whereas in the liquid-condensed region, the molecules are oriented vertically (with the area of 55 2 2 / molecule), and most of the hydrogen bonds are broken. The phase transition was interpreted as being due to the changes in molecules orientation from horizontal to vertical position [22,47]. We have also performed semi-empirical calculations of cross-sectional areas for MF-AME using a HyperChem computer program [48].…”

Section: Monolayers Formed By Pure Mf-amementioning

confidence: 99%

Interactions of amphotericin B derivative of low toxicity with biological membrane components—the Langmuir monolayer approach

Hąc-Wydro

Dynarowicz-Łątka

Grzybowska

et al. 2005

Biophysical Chemistry

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“…To address this issue, Langmuir monolayers have been used involving AmB alone as well as mixed with membrane sterols. The pressure-area isotherm of AmB revealed its conformational changes from a horizontal to a vertical position upon compression [123,124], later confirmed with BAM [125] and ATR-FTIR spectroscopy [130,131] for Langmuir films.…”

Section: Accepted Manuscriptmentioning

confidence: 58%