The Basis for a Rational Nutritional Approach to Patients with Cancer

Fanelli, Filippo Rossi; Muscaritoli, Maurizio; Cangiano, C.; Cascino, A.; Laviano, Alessandro; Fava, Alessandra

doi:10.1007/978-1-4615-4797-6_29

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2003

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“…It contributes to the development of malnutrition and cachexia, since it promotes skeletal muscle wasting by reducing the oral intake of calories. Thus, it exacerbates the detrimental effects of tumor-related alterations of protein metabolism on nutritional status, eventually leading to increased morbidity and mortality [1]. Alternatively, the metabolic dysregulation of cachexia sustains and corroborates the neurochemical alterations responsible for anorexia.…”

Section: Introductionmentioning

confidence: 94%

Improving food intake in anorectic cancer patients

Laviano

Meguid

Rossi-Fanelli

2003

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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In the pathogenesis of cancer anorexia, cytokines appear to play a key role. Their increased expression during tumor growth inhibits the hypothalamus to appropriately respond to peripheral signals, by persistently activating the melanocortin system and inhibiting the neuropeptide Y neuronal pathway. Hypothalamic monoaminergic neurotransmission may significantly contribute to these effects. Thus, interfering pharmacologically with cytokine expression or hypothalamic monoaminergic neurotransmissions is an effective therapeutic strategy in anorectic cancer patients.

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Section: Introductionmentioning

confidence: 94%