Improving food intake in anorectic cancer patients

Laviano, Alessandro; Meguid, Michael M.; Rossi-Fanelli, Filippo

doi:10.1097/01.mco.0000078985.18774.4b

Cited by 13 publications

(8 citation statements)

References 38 publications

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“…Some specific nutrients, such as eicosapentaenoic acid (EPA), an omega-3 polyunsaturated acid, and drugs such as megestrol acetate, a progestational agent, have been shown to improve anorexia and quality of life in cancer patients [5,6,21]. In malnourished cancer patients undergoing ablative or demolishing surgery, artificial nutritional support is often indicated.…”

Section: Metabolic and Nutritional Support During Active Anti-neoplasmentioning

confidence: 99%

“…The diagnosis of anorexia through specific questionnaires is becoming a common and effective practice providing a qualitative assessment in addition to a quantitative evaluation made by the visual analog scale (VAS) [5]. The pathogenesis of cancer-related anorexia is multifactorial and involves disruption of central and peripheral signals that physiologically regulate eating behaviour [6]. Under physiological conditions, the hypothalamus integrates peripheral signals resulting in modulation of energy intake by means of interaction with the adipose tissue, the digestive processes and the metabolic profile.…”

Section: Pathogenesis Of Malnutrition and Cachexia In Cancer Patientsmentioning

confidence: 99%

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The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients

et al. 2010

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Cancer-associated malnutrition results from a deadly combination of anorexia, which leads to reduced food intake, and derangements of host metabolism inducing body weight loss, and hindering its reversal with nutrient supplementation. Cancer patients often experience both anorexia and weight loss, contributing to the onset of the clinical feature named as anorexia-cachexia syndrome. This condition has a negative impact upon patients' nutritional status. The pathogenesis of the anorexia-cachexia syndrome is multifactorial, and is related to: tumour-derived factors, host-derived factors inducing metabolic derangements, and side effects of anticancer therapies. In addition, the lack of awareness of cancer patients' nutritional issues and status by many oncologists, frequently results in progressive weight loss going undiagnosed until it becomes severe. The critical involvement of host inflammatory response in the development of weight loss, and, in particular, lean body mass depletion, limits the response to the provision of standard nutrition support. A novel nutritional and metabolic approach, named "parallel pathway", has been devised that may help maintain or improve nutritional status, and prevent or delay the onset of cancer cachexia. Such an approach may improve tolerance to aggressive anticancer therapies, and ameliorate the functional capacity and quality of life even in advanced disease stages. The "parallel pathway" implies a multiprofessional and multimodal approach aimed at ensuring early, appropriate and continuous nutritional and metabolic support to cancer patients in any phase of their cancer journey.

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Section: Metabolic and Nutritional Support During Active Anti-neoplasmentioning

confidence: 99%

Section: Pathogenesis Of Malnutrition and Cachexia In Cancer Patientsmentioning

confidence: 99%

The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sometimes, reduced energy intake is assumed as a measure of anorexia; however, a note of caution should be introduced, since the reduction of ingested calories may result from dysphagia or depression rather than from anorexia [7]. The pathogenesis of cancer-related anorexia is complex and multifactorial, implying a disruption of the central and peripheral messages that physiologically regulate eating behaviour [7,8]. Patients affected by chronic diseases often show disorders of nutrient balance.…”

Section: Anorexiamentioning

confidence: 99%

New Strategies for Metabolic Support in Cancer

Muscaritoli¹,

Costelli²,

Molfino³

et al. 2012

CNF

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The management of cancer patients is frequently complicated by the occurrence of cachexia, a complex syndrome characterized by marked depletion of body weight, associated with profound alterations of both nutritional status and metabolic homeostasis. Progressive wasting of skeletal muscle mass and adipose tissue is a typical feature of cancer cachexia. This syndrome has a large impact on morbidity and mortality, and significantly affects patients' quality of life. On this line, understanding the pathogenic mechanisms of cachexia is of crucial importance to define targeted therapeutic strategies.Many studies have addressed the relevance of nutritional interventions in cancer hosts. In particular, it has been shown that malnutrition in cancer patients can be delayed when nutritional supplementation is adopted early in the course of the disease. The preservation of a good nutritional status, in particular when it is achieved concurrently with specific antineoplastic treatment, will prevent or at least delay the onset of overt cachexia, allowing the use of more aggressive therapeutic regimens.This extended and updated version of our previously published article titled " Nutritional support in cancer" will review the most recent and relevant literature, focusing on those options that have shown more promising for the clinical practice.

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“…The pathogenesis of cancer-related anorexia is complex and multifactorial, implying a disruption of the central and peripheral messages that physiologically regulate eating behaviour [7,8]. In physiological conditions the hypothalamus integrates peripheral signals, resulting in the modulation of energy intake by interacting with adipose tissues, digestive processes, and metabolic profile.…”

Section: Anorexiamentioning

confidence: 99%

Nutritional Support in Cancer

Costelli¹,

Muscaritoli²,

Penna³

et al. 2007

CNF

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The management of cancer patients is frequently complicated by the occurrence of cachexia, a complex syndrome characterized by marked depletion of body weight, associated with profound alterations of both nutritional status and metabolic homeostasis. Progressive wasting of skeletal muscle mass and adipose tissue is a typical feature of cancer cachexia. This syndrome has a large impact on morbidity and mortality, and significantly affects patients' quality of life. On this line, understanding the pathogenic mechanisms of cachexia is of crucial importance to define targeted therapeutic strategies.Many studies have addressed the relevance of nutritional interventions in cancer hosts. In particular, it has been shown that malnutrition in cancer patients can be delayed when nutritional supplementation is adopted early in the course of the disease. The preservation of a good nutritional status, in particular when it is achieved concurrently with specific antineoplastic treatment, will prevent or at least delay the onset of overt cachexia, allowing the use of more aggressive therapeutic regimens. This paper will review the relevant literature, focusing on those options that have shown more promising for the clinical practice.

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Improving food intake in anorectic cancer patients

Cited by 13 publications

References 38 publications

The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients

The “parallel pathway”: a novel nutritional and metabolic approach to cancer patients

New Strategies for Metabolic Support in Cancer

Nutritional Support in Cancer

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