The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors

Won, Chong Hyun; Park, Gyeong Hun; Wu, Xunwei; Tran, Thanh Nga; Park, Ki young; Park, Byung Soon; Kim, Dong Young; Kwon, Oh Sang; Kim, Kyu Han

doi:10.2174/1574888x12666170829161058

Cited by 51 publications

(46 citation statements)

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“…Localized supplementation of growth factors and cytokines favoring hair growth was reported to promote hair regeneration [8]. Previous reports show that ADSC-CM promoted hair growth by regulating the cell cycle and inducing the anagen phase of the hair cycle, thereby promoting the proliferation of DPCs and possibly epithelial cells [9]. Our current results are consistent with those findings.…”

Section: Discussionsupporting

confidence: 91%

“…ADSCs-CM has been reported to be rich in growth factors and cytokines, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and insulin-like growth factor I (IGF-I) [8]. These growth factors and cytokines potentially modulate the host environment and thereby play significant roles in hair growth [9]. Previous studies found that human hair regrowth and density increased significantly after the application of ADSCs-CM [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

Xiao

Deng

et al. 2020

Stem Cells International

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Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth. Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy. In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice. ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction. ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth. These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

Xiao

Deng

et al. 2020

Stem Cells International

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“…While our pilot study suggests that transplanted nestin + cells stimulate keratinocyte migration, the underlying mechanism is unclear. However, given that mesenchymal stem cells are well known for their extensive repertoire of secretory activities [ 8 , 19 , 20 ], it is conceivable that nestin + progenitor cells, which may be comparable in their highly plastic differentiation potential to adipose-derived mesenchymal stem cells, also impact on keratinocyte migration by secreting migration-enhancing growth factors. Clearly, future studies will have to determine how nestin + cells influence the balance between keratinocyte proliferation, apoptosis, migration and differentiation, culminating in the acceleration of epidermal repair.…”

Section: Discussionmentioning

confidence: 99%

Nestin+ progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo

et al. 2019

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The combination of an aging population and an increasing prevalence of diseases associated with impaired-wound healing, including obesity, peripheral vascular disease and diabetes, is likely to result in a dramatic increase in the incidence and prevalence of chronic skin wounds. Indeed, systemic reviews are now not only trying to establish both the prevalence and the often under-estimated socio-economic costs of chronic skin wounds, but most importantly are addressing the impact that chronic wounds have on quality of life. Given the clear need for novel approaches to the management of chronic skin ulceration, ideally developed and tested in the human system in a manner that can be rapidly translated into clinical practice, we examined the effects of multipotent primary human nestin + progenitor cells on human wound healing in an ex vivo model. Human sweat gland-derived nestin + cells demonstrated the capacity to significantly promote two key wound healing parameters, i.e., both reepithelialisation and angiogenesis in experimentally wounded, organ-cultured human skin. The current data further support the use of full-thickness human skin wound-healing models ex vivo to pre-clinically test wound healing-promoting candidate agents. Whilst larger studies are required to substantiate a firm “proof-of-concept,” our preliminary studies encourage further efforts to systemically determine the potential of cell-based regenerative medicine strategies in general, and the use of skin appendage-associated human nestin + cells in particular, as novel treatment strategies for chronic skin ulceration. Electronic supplementary material The online version of this article (10.1007/s00403-019-01889-x) contains supplementary material, which is available to authorized users.

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“…AGA is characterized by shortening of the anagen phase and prolongation of the telogen phase, resulting in HF miniaturization in androgen-sensitive scalp and conversion into vellus hair [7]. Thus, the majority of prospective therapeutic strategies for AGA treatment involve the modulation of hair cycle dynamics, specifically prolonging or inducing the anagen phase [8,9]. The present article focuses on the current methods used to evaluate the hair growth-promoting effects of candidate substances, providing a useful overview of published hair growth evaluation assays in cells, organs, and animal models (Table 1 and Fig.…”

Section: Introductionmentioning

confidence: 99%

Evaluating hair growth promoting effects of candidate substance: A review of research methods

Ohn

Kim

Kwon

2019

Journal of Dermatological Science

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Androgenetic alopecia (AGA) is the most common form of hair loss disorder. As the prevalence of AGA rises, the demand for AGA treatments is rising accordingly, prompting research to identify therapeutic candidates to treat AGA. Because AGA is caused by crosstalk among multiple hair follicle (HF) cell components, understanding the effects of candidate molecules on HF cells is essential to determining therapeutic candidates for treatment. To date, research has centered on HF dermal papilla and outer root sheath cells and has indicated that the hair growth effects of candidate substances may be mediated via alterations in several signaling pathways and signature genes in these HF cells. In more integrative evaluations, the HF unit is used as an ex vivo organ culture model to verify the effects of therapeutic candidates. Animal models have also been used to evaluate the effects of candidate substances. The main outcomes used to evaluate the effects of candidate substances are 1) changes in HF growth rates in vitro, 2) anagen induction capabilities, and 3) the effects of androgen modulation. This article reviews a series of methods used to evaluate the hair growth-promoting effects of candidate substances, providing an overview of cell assays, organs, and animal models used in AGA research in order to facilitate AGA research moving forward.

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The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors

Abstract: ADSC-CM promotes hair growth in vitro, ex vivo, and in vivo. Given that ADSCs are one of the most accessible sources of MSCs, ADSC-derived proteins may be feasible clinical therapeutic agents for the treatment of hair loss.

Cited by 51 publications

References 0 publications

Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

Nestin+ progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo

Evaluating hair growth promoting effects of candidate substance: A review of research methods

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