The basement membrane. Interface between the epithelium and the dermis: structural features

Three keratin gene mutations account for the majority of dominant simplex epidermolysis bullosa cases within the population of Ireland

“…The latter also has distinctive tonofilament clumping in basal cells (Anton-Lamprecht and Schnyder, 1982). Junctional and Dystrophic EB are characterized by blistering in the plane of the lamina lucida of the basement membrane zone and below the dermal-epidermal basement membrane at the level of the anchoring fibrils, respectively (Eady, 1988;Fine et al, 1991;Uitto and Christiano, 1992 (laminins) in patients displaying junctional forms of EB (Pulkkinen et al, 1994a,b), whereas mutations within the type VII collagen (COL7Al) gene have been identified in pedigrees displaying dystrophic forms of EB (Christian0 et al, 1993(Christian0 et al, , 1994Hilal et al, 1993;Hovnanian et al, 1994 keratins are numbered K1-K8 and are larger than the type I keratins (numbered K9-K20), owing to their V1 and V2 subdomains, which vary in length and sequence and have a high glycine content (Moll et al, 1982 fashion, to form a heterodimer. Subsequently, two heterodimers form a tetramer and groups of tetramers form protofilaments (2-3 nm), which in turn group to form protofibrils (4-5 nm).…”

Honeycomb structure in the lamina lucida of epidermal basement membrane during metamorphosis of Rana temporaria ornativentris

“…Most likely, the fine structure of the lamina lucida has not yet been fully described. Subbasal dense plates, observed at hemidesmosomes, and the anchoring filaments are the only structures that have been reported at the electron microscopic level (Susi et al, 1967;Hashimoto et al, 1970;Briggaman and Wheeler, 1975;Briggaman, 1982;Tidman and Eady, 1984;Eady, 1988;Osawa and Nozaka, 1995). These structures can be easily recognized without any special staining.…”

“…The general structure of the lamina lucida includes the presence of anchoring filaments and subbasal dense plates (Susi et al, 1967;Hashimoto et al, 1970;Briggaman and Wheeler, 1975;Briggaman, 1982;Tidman and Eady, 1984;Eady, 1988;Osawa and Nozaka, 1995). Other than these structures, a meshwork structure, which divided the lamina lucida into two layers with the same thickness, was reported only in young animals Nozaka, 1991, 1992).…”

Epidermal Basement Membrane: Its Molecular Organization and Blistering Disorders

“…Based on the results of pre-embedding immunoelectron microscopy, anchoring fibrils were previously thought to form a network in the papillary dermis through the amorphous structures called anchoring plaques [53]. However, neither such networks nor the anchoring plaques themselves are usually observed in electron microscopic studies [54].…”