The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Spiegeleer, Anton De; Wynendaele, Evelien; Descamps, Amélie; Debunne, Nathan; Braeckman, Bart P.; Mey, Marjan De; Coudenys, Julie; Crombez, Liesbeth; Verbeke, Frederick; Janssens, Yorick; Janky, Rekin’s; Goossens, Evy; Vlaeminck, Caroline; Duchi, Dries; Andries, Vanessa; Dumas, Émilie; Petrovic, Mirko; Wiele, Tom Van de; Knappe, Daniel; Hoffmann, Ralf; Mouly, Vincent; Bigot, Anne; Vereecke, Lars; Immerseel, Filip Van; Noortgate, Nele Van Den; Spiegeleer, Bart De; Elewaut, Dirk

doi:10.1002/ctm2.1053

Cited by 9 publications

(1 citation statement)

References 12 publications

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“…Other mechanisms include that the quorum-sensing peptide iAM373 produced by Enterobacter faecalis during bacterial dysregulation downregulated most skeletal muscle development and differentiation genes, reduced the metabolic activity of myoblast cells, and upregulated the proteasome degradation pathway in muscle ducts, which is a new inducer of sarcopenia. 80 Cohort research has suggested that sarcopenia is also correlated with a decrease in short-chain fatty acid (SCFAs)-producing gut microbiota, resulting in an imbalance in gut flora. 81 , 82 Dysregulation of the intestinal flora may lead to skeletal muscle atrophy through upregulation of the primary bile acid-farnesoid X receptor pathway.…”

Section: Effects and Mechanism Of The Intestinal Microbiota On The Mu...mentioning

confidence: 99%

Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values

Wang,

Li,

et al. 2023

Gut Microbes

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The musculoskeletal system is important for balancing metabolic activity and maintaining health. Recent studies have shown that distortions in homeostasis of the intestinal microbiota are correlated with or may even contribute to abnormalities in musculoskeletal system function. Research has also shown that the intestinal flora and its secondary metabolites can impact the musculoskeletal system by regulating various phenomena, such as inflammation and immune and metabolic activities. Most of the existing literature supports that reasonable nutritional intervention helps to improve and maintain the homeostasis of intestinal microbiota, and may have a positive impact on musculoskeletal health. The purpose of organizing, summarizing and discussing the existing literature is to explore whether the intervention methods, including nutritional supplement and moderate exercise, can affect the muscle and bone health by regulating the microecology of the intestinal flora. More in-depth efficacy verification experiments will be helpful for clinical applications.

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Section: Effects and Mechanism Of The Intestinal Microbiota On The Mu...mentioning

confidence: 99%