The Bacterial Degradation of Pantothenic Acid. III. Enzymatic Formation of Aldopantoic Acid^*

Synthesis and characterizations of new isotactic homopolyesters, statistical and block copolyesters derived of poly((S)‐3,3‐dimethylmalic acid) via the lactone route

“…This molecule appears in the synthesis of Coenzyme A catalyzed by the enzyme b,bdimethyldehydrogenase (EC.1.1.1.84) to give ketovaline (Scheme 1). 16 Moreover, in the literature, the hydrolysis of atactic poly((R,S)-3,3-dimethylmalic acid) gave the corresponding (R,S)-3,3-dimethylmalic acid. 16,17 Anionic ring-opening polymerization of chiral a,a,b-trisubstituted-b-lactones leads to a large family of semicrystalline and isotactic poly((R)-3,3-dimethylmalic acid) derivatives having lateral functional group with high molecular weight (Scheme 2).…”

Diversity of the Degradation of Panthenol by Microorganisms

“…. h 11 k [24][25][26][27][28][29][30][31] orgamsms IS rat er we nown. Puis to and Nurmikk0 32 ) and Mantsala and Nurmikko33) reported that Pseudomonas fiuorescens P-2 contains an inducible amidase, pantothenate hydrolase, which hydrolyzes pantothenate to pantoic acid and !'i-alanine.…”

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

“…To find the ideal structure of the monomer, a thorough research on the various known metabolisms resulted in the existence of the biosynthesis of pantothenate and Coenzyme A from (R)--3,3-dimethylmalic acid [78][79][80]. As this (R)-3,3-dimethylmalic acid is a natural and non-toxic compound, a new study was directed towards the synthesis of α,α',β-trisubstituted β-lactones completely unreported.…”

“…Indeed, (R)-3,3-dimethylmalic acid which is the final product of hydrolytic degradation of chiral PDMMLA is a natural and non-toxic product involved in the biosynthetic pathway of pantothenate. This metabolite is present in the synthesis of Coenzyme A and gives ketovaline by enzymatic oxidative reaction catalyzed by β,β--dimethyldehydrogenase (EC.1.1.1.84) [78,80,81,91,92] (Figure 3). [93].…”