Diversity of the Degradation of Panthenol by Microorganisms

Fluorescence Assay for the Determination of d-Panthenol Based on Novel Ring-Fused 2-Pyridone Derivative

“…Ultimately, it was possible to synthesize and separate fluorophore in the proper amount and purity, thereby allowing for comprehensive characterization studies of the chemical structure ( Figure S1). Simultaneously, CA was reacted with 3-amino-1-propanol and separately with pantolactone (thermal degradation products of panthenol) [19,34] and resulting reaction mixtures were dissolved in methanol and analyzed with LC-DAD-MS. The above analyses were aimed at identifying the part of the DP molecule that is capable of reacting with CA to form a compound that absorbs around 350 nm.…”

“…In order to improve the sensitivity of DP assays, some derivatization methods have been introduced. In most cases, these methods consist of hydrolysis of DP for the production of β-alanol (3-amino-1-propanol), a primary amine susceptible to the reaction of nitrobenzoxadiazole (NBD) and ninhydrin for the formulation of colored or fluorescent derivatives [12][13][14][15][16][17][18][19]. Thus, using fluorescence DP assays, it is possible to easily achieve LOD (Limit of Detection) as low as 10 −8 g/mL [12].…”

Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis

“…The asymmetric synthesis of ( R )-pantolactone (( R ) -1 , Figure ) continues to be of interest to organic chemists due to its wide use as a chiral auxiliary − and key industrial intermediate for the production of pantothenate. , Besides the inhibitory effects of optically pure ( R )- 1 toward lactic acid bacteria and malaria, , it serves as a starting material for the preparation of ( R )-panthenol, ( R )-pantetheine, and pantoyl taurine, which has been shown to inhibit the growth of certain strains of diphtheria bacilli, among others. Furthermore, ( R )- 1 is a key building block for natural products like 4′-phosphopantetheine, the prosthetic group of fatty acid synthase, and pantothenic acid (vitamin B5, Figure ), which is needed for the biosynthesis of coenzyme A (CoA). , …”

Enantioselective Synthesis of (S)-(+)-Pantolactone

“…The asymmetric synthesis of pantolactone continues to be an area of active interest due to its utility as a building block in the synthesis of natural products and their analogues , and the biological activity of pantothenic acid and ( R )-panthenol . In addition, pantolactone has found application as a chiral auxiliary in asymmetric synthesis .…”