Scheme 2. Synthesis of 1. Reagents and conditions: a) NMM, methyl propiolate, anhydrous CH 2 Cl 2 , 08C!RT, 6 h, 91 %; b) NaH, anhydrous THF, methyl 3-iodoacrylate, 0 8C!RT, 3 h, 80 %; c) DCA, DMN, ascorbic acid, DMF/iPrOH/H 2 O, 60 h, 62 %; d) TFA, anhydrous CH 2 Cl 2 , 5 h, 95 %. Boc = tert-butyloxycarbonyl.