The Autonomic Innervation of the Rat Testicular Capsule

Bell, Chris; McLean, John H.

doi:10.1530/jrf.0.0320253

Cited by 41 publications

(17 citation statements)

References 12 publications

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“…The high concentration of 5-HT found in the isolated testicular capsule (Table 1) could be related to the presence of fine fluorescent nerve fibres described previously (Bell & McLean, 1973), since no other fluorescent structures were observed within the capsule. The histochemical technique used (Falck & Owman, 1965) in these studies identifies all monoamines and therefore serotonergic innervation might also be part of the fluorescent fibres seen in the capsule.…”

Section: Discussionsupporting

confidence: 60%

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Serotonergic innervation of the rat testis

Campos

Vitale²,

Calandra³

et al. 1990

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Summary. The presence of 5-hydroxytryptamine (5-HT) was determined by h.p.l.c. in perchloric extracts of each isolated compartment of the adult rat testis. The testicular capsule, interstitial cells and interstitial fluid contained 5-HT, but 5-HT was not detected in the tubular compartment.In a group of adult rats, one testis was unilaterally denervated, and the contralateral testis used as control. The superior spermatic nerve, arising from the renal plexus, was excised and 1 week after surgery 5-HT content was measured in the capsule and interstitial fluid of both testes. Denervation caused a significant fall (34%) in 5-HT content. These results indicate that at least part of the testicular 5-HT derives from a serotonergic innervation of the gonad.

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Section: Discussionsupporting

confidence: 60%

“…Histochemical studies (Bell & McLean, 1973) revealed the presence of fluorescent nerve fibres in the tunica albugínea and tunica vasculosa. This capsular innervation was shown to be mainly adrenergic, with a minor cholinergic component.…”

Section: Introductionmentioning

confidence: 99%

Serotonergic innervation of the rat testis

Campos

Vitale²,

Calandra³

et al. 1990

Reproduction

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“…Recently, Bell and McLean (1973) demonstrated pharmacologically and histochemically that the rat testicular capsule receives the autonomic innervation. In their histochemical studies of the epididymis, Baumgarten et al (1968) and Sjostrand (1965) found an abundance of CA fluorescent fibers.…”

Section: Discussionmentioning

confidence: 99%

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

Shirai

Sasaki

Rikimaru³

1973

Tohoku J. Exp. Med.

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-A histochemical studies clarified the peripheral distribution of adrenergic and cholinergic nerves in the human male genital organs. In the human testis, there was a minimal distribu tion of catecholamine fluorescent fibers and acetylcholinesterase positive fibers around the blood vessels and in the interstitium. In the epididymis and the vas deferens, both nerve fibers were abundant in the muscle layer and interstitium. However, no difference in the distribution of these nerve fibers was noted according to the anatomical site of these organs. In the prostate, acetylcholinesterase positive fibers were abundant; but catecholamine fluorescent fibers were relatively few, and found in the interstitium and the muscle layer. These two types of nerve fibers were not found in the epithelial cell layer of the organs. catecho lamine; acetylcholinesterase; testis; epididymis; vas deferens; prostate Little is known about the innervation of the human male gential organs, especially of the testis, epididymis, vas deferens, prostate and penis, though the functions of these organs, i.e., spermatogenic function, ejaculation and erection are well known to be controlled by the nerves. There have been few histochemical studies on the distribution and course of the peripheral nerve supply to these organs.The silver staining method, which was used in the past for studies of the nervous system, is inadequate for accurate classification of the sympathetic and parasym pathetic peripheral nerve distribution in the genital organs.Recently, however, it has become possible to use catecholamine (CA) fluores cence as a histochemical index in order to demonstrate the distribution of adrenergic nerves. The distribution of cholinergic nerves has been demonstrated, using acetylcholinesterase (ACNE) as an index.The authors have already shown histochemically the localization of adrener gic and cholinergic nerves in the human penis . In the present study, the authors have demonstrated histochemically the localization of adrener-

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“…Most testicular nerves seem to be catecholaminergic (Bell and McLean, 1973;Campos et al, 1990a,b;Zhu et al, 1995;Wrobel and Moustafa, 2000), but peptidergic fibers have been found in every species. Testicular nerves are a heterogeneous population.…”

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Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

Suburo

Chiocchio

Soler

et al. 2002

Journal of Andrology

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ABSTRACT:We studied the innervation of the cat testis using a panel of antisera against the following neuronal markers: protein gene product 9.5 (PGP), neuropeptide Y, C-terminal peptide of neuropeptide Y, galanin, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide, and substance P. Immunoreactivity against PGP, a general neuronal label, demonstrated the arrangement of fibers from the superior spermatic nerve (SSN) in the testicular pedicle and the cephalic testicular pole, and those of the inferior spermatic nerve (ISN) along the vas deferens and the inferior testicular ligament. The testicular parenchyma exhibited a very rich innervation, mainly distributed to blood vessels and Leydig cell nests, but also in close association with seminiferous tubules. Numerous peptidergic fibers were present in the SSN and ISN, albeit in different proportions. Thus, VIP-immunoreactive fibers were almost absent in the SSN, but were the most abundant subpopulation of the ISN. The testicular interstitium contained numerous peptidergic fibers, associated with blood vessels, interstitial Leydig cells, and seminiferous tubules. Similar fibers were related to the rete testis. Parenchymatous VIP-immunoreactive nerves disappeared after bilateral vasectomy. Stimulation of the ISN under experimental conditions was associated with an increase of blood flow, and induced a large release of VIP into the spermatic vein. The extensive and selective distribution of nerve fibers within the cat testicular parenchyma supports the importance of spermatic nerves for testicular function. Furthermore, the differences in the fiber composition of the SSN and ISN can be correlated with their opposing effects on testosterone secretion and testicular blood flow.

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The Autonomic Innervation of the Rat Testicular Capsule

Abstract: Summary. The

Cited by 41 publications

References 12 publications

Serotonergic innervation of the rat testis

Serotonergic innervation of the rat testis

A Histochemical Investigation of the Distribution of Adrenergic and Cholinergic Nerves in the Human Male Genital Organs

Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

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