Serotonergic innervation of the rat testis

Campos, María; Vitale, María Leiza; Calandra, Ricardo S.; Chiocchio, Sara R.

doi:10.1530/jrf.0.0880475

Cited by 39 publications

(37 citation statements)

References 9 publications

(10 reference statements)

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“…In the testis, there are several potential serotonin sources: nerve endings in the testicular capsule, mast cells and Leydig cells (Gaytan et al 1989, Campos et al 1990, Tinajero et al 1993. However, the contribution of the different potential sources to the total amount of serotonin in the testis is not known (Aguilar et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

Martínez¹,

Ayala²,

Marin³

et al. 2005

Reproduction

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The stimulatory and inhibitory role of serotonin in gonadotropin secretion and in the onset of puberty in the male rat has been previously described, but its role in the establishment of spermatogenesis is not known. The aim of this study was to investigate the effects of serotoninergic inhibition by p-chloroamphetamine (pCA) on the prepubertal-to-adult stage of the rat reproductive system. Hypothalamic serotonin, gonadotropins and sex steroid hormone concentrations were measured, and a histopathological analysis of seminiferous epithelium was carried out on animals treated with pCA from day 30 and killed at 45 or 65 days of age. The pCA treatment significantly reduced the hypothalamic levels of serotonin and its metabolite (5-hydroxyindole-3-acetic acid). This inhibition did not affect the sex steroid hormone or LH concentrations, but rather it induced an increase in FSH concentration in animals of both ages. Spermatogenesis was impaired by pCA treatment. Disruption of seminiferous epithelium and the death of numerous germ cells were observed. Sperm produced by pCA-treated animals was of poor quality and appeared in small quantities. Apparently, serotonin depletion did not affect communication between the hypothalamus and the pituitary, but the FSH increase could have been related to alterations in the seminiferous epithelium effects. The seminiferous epithelium cycle was altered in rats killed at both 45 and 65 days of age, because at each age of killing the distribution of spermatogenesis stages was different. Germ cell apoptosis did not appear to be related to changes in the FSH concentrations, but other factors produced during spermatogenesis could have been involved in this induction. This study showed that serotonin was necessary for the development of normal spermatogenesis in prepubertal rats. Reproduction (2005) 129 717-727

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Section: Discussionmentioning

confidence: 99%

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

Martínez¹,

Ayala²,

Marin³

et al. 2005

Reproduction

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“…The only information available is that denervation reduced intratesticular 5-HT by 34% (Campos et al, 1990). It has been shown, however, that 5-HT could be an important autocrine or paracrine regulator of Leydig cell function (Dufau et al, 1993;Tinajero et al, 1993a, b (Dufau el al, 1993;Tinajero et al, 1993b) and previous studies have demonstrated testicular atrophy after administration in high doses (see Free, 1977 (Yang et al, 1990(Yang et al, , 1992.…”

Section: -Hydroxytryptamine Antagonist (Ritanserin Ketanserinmentioning

confidence: 99%

“…The concentration of 5-HT in rat plasma is reported to be 3.9 ng ml-1 and in testicular interstitial fluid to 23 ng ml- (Campos et al, 1990). The high content in interstitial fluid could be an overestimation, as 5-HT could have been released from cells during the collection of interstitial fluid (Maddocks and Setchell, 1988 (Campos et al, 1990) and Leydig cells (Tinajero et al, 1993b).…”

Section: -Hydroxytryptamine Antagonist (Ritanserin Ketanserinmentioning

confidence: 99%

“…The high content in interstitial fluid could be an overestimation, as 5-HT could have been released from cells during the collection of interstitial fluid (Maddocks and Setchell, 1988 (Campos et al, 1990) and Leydig cells (Tinajero et al, 1993b). The relative contributions from these sources are unknown, and there is no information available on whether intratesticular 5-HT concentration in vivo is influenced by physiological regulators of testicular function.…”

Section: -Hydroxytryptamine Antagonist (Ritanserin Ketanserinmentioning

confidence: 99%

“…Mast cells, which are a major source of vasoactive substances, and inflammation mediators like 5-hydroxytryptamine (5-HT) and histamine, are present around the subcapsular part of the main testicular artery (Sowerbutts et al, 1986), and mast cells are probably involved in the control of blood flow in other steroid hormone producing organs like the ovary (Krishna et al, 1989) and the adrenal cortex (Hinson et al, 1989). Treatment with hCG causes mast cell degranulation (Morales and Heyn, 1992) (Bergh and Damber, 1993 (Campos et al, 1990), and Leydig cells in response to hCG stimulation (Tinajero et al, 1993a, b). Ketan¬ serin (a 5-HT antagonist) inhibits the hCG-induced increase in testicular interstitial fluid volume (Sowerbutts et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

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5-Hydroxytryptamine - a local regulator of testicular blood flow and vasomotion in rats

Collin¹,

Damber²,

Bergh³

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Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

Ala

Ghasemi

Jafari

et al. 2021

Drug Development Research

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Sumatriptan is the first available medication from triptans family that was approved by the U.S. Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of its action is mediated by selective 5‐HT1B/1D receptor agonism. Recent investigations raised the possibility of repositioning of this drug to other indications beyond migraine, as increasing evidence suggests for an anti‐inflammatory property of sumatriptan. We performed a literature search using PubMed, Web of Science, Scopus, and Google Scholar using “inflammation AND sumatriptan” or “inflammation AND 5HT1B/D” as the keywords. Then, articles were screened for their relevance and those directly discussing the correlation between inflammation and sumatriptan or 5HT1B/D were included. Total references reviewed or inclusion/exclusion were 340 retrieved full‐text articles (n = 340), then based on critical assessment 66 of them were included in this systematic review. Our literature review indicates that at low doses, sumatriptan can reduce inflammatory markers (e.g., interleukin‐1β, tumor necrosis factor‐α, and nuclear factor‐κB), affects caspases and changes cells lifespan. Additionally, nitric oxide synthase and nitric oxide signaling seem to be regulated by this drug. It also inhibits the release of calcitonin gene‐related peptide. Sumatriptan protects against many inflammatory conditions including cardiac and mesenteric ischemia/reperfusion, skin flap, pruritus, peripheral, and central nervous system injuries such as spinal cord injury, testicular torsion‐detorsion, oral mucositis, and other experimental models. Considering the safety and potency of low dose sumatriptan compared to corticosteroids and other immunosuppressive medications, it is worth to take advantage of sumatriptan in inflammatory conditions.

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Serotonergic innervation of the rat testis

Cited by 39 publications

References 9 publications

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development

5-Hydroxytryptamine - a local regulator of testicular blood flow and vasomotion in rats

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

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