The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

Ouyang, Jun; Yang, Lu; Huang, Xin; Zhong, Yang; Hu, Pei-Hong; Zhang, Ying; Pei, Chong-Gang; Shao, Yi

doi:10.3892/mmr.2017.7006

Cited by 41 publications

(42 citation statements)

References 31 publications

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“… 39 , 40 Researches of strabismus subjects suggested that white matter volume was reduced in the right precuneus in the comitant strabismus patients. 41 Nevertheless, Yang et al found a significant increase of the bold signal in the bilateral precuneus in the patients with infantile esotropia, 42 and cortical activations in intermittent exotropia were found in right precuneus. 23 In the present study, we detected an increased ALFF in the right precuneus of SA group.…”

Section: Discussionmentioning

confidence: 96%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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ObjectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects.Patients and methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson’s correlation analysis.ResultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.ConclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.

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Section: Discussionmentioning

confidence: 96%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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“…Voxel-based morphometry of magnetic resonance imaging (MRI) data involves the normalization of all image spaces into the same stereotactic space, and extraction of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF), smoothing, and, finally, statistical analysis to determine the differences between groups (Thomas & Bahaei, 2012). The voxel-based morphometry (VBM) technique has been used in ophthalmic diseases such as amblyopia, strabismus, glaucoma, and optic neuritis (Barnes et al, 2010;Huang et al, 2016;Li et al, 2012;Ouyang et al, 2017).…”

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confidence: 99%

Central network changes in patients with advanced monocular blindness: A voxel‐based morphometric study

Shi

Tang

et al. 2019

Brain and Behavior

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Objective To study the changes in gray matter volume (GMV) in patients with advanced monocular blindness (MB) using voxel‐based morphometry (VBM). Methods Thirty‐one patients with advanced MB (25 males and six females) and 31 normal controls (25 males and six females) were enrolled. The t test was applied to determine the differences in GMV, white matter volume (WMV), and volume of cerebrospinal fluid in different regions of the brain. The local characteristics of spontaneous concentrations of brain tissue were evaluated by the VBM method. The effects of blindness duration on differences in the GMV were evaluated by correlation and regression analyses. Results Compared with the control group, the GMV was decreased in the upper right margin, bilateral insular cortex, right cingulate gyrus, left occipital gyrus, and right suboccipital lobe, and negatively correlated with blindness duration in the upper right posterior margin, bilateral insular cortex, and right cingulate cortex. Conclusions We found that patients with MB showed abnormal WMV and GMV, as evidenced by local changes in the brain. In addition, reduced GMV in specific parts of the brain was associated with the duration of blindness, which may indicate neuropathological mechanisms of visual loss in patients with MB.

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“…Similarly, we assumed that the functional abnormalities in the POS might be connected with visuomotor abnormalities such as pointing errors in XT patients 34 . Besides functional alteration, recent microstructural studies have confirmed grey matter atrophy in the POS of patients with strabismus 35 …”

Section: Discussionmentioning

confidence: 91%

Disrupted neural signals in patients with concomitant exotropia

Yao

Zhang

et al. 2020

Ophthalmic Physiologic Optic

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Purpose Decreased binocular and oculomotor function in strabismics has recently been considered as cortical in origin. This study aimed to investigate functional abnormalities using a frequency‐specific neuroimaging method in patients with concomitant exotropia (XT), and to demonstrate the clinical implications. Methods Resting‐state functional magnetic resonance imaging data were collected in 26 XT patients and 26 matched controls. To evaluate the local spontaneous neural activity, the amplitude of low frequency fluctuations (ALFF) was calculated in the typical frequency band (0.01–0.08 Hz) as well as five narrowly‐defined frequency bands (slow‐6: 0–0.01 Hz, slow‐5: 0.01–0.027 Hz, slow‐4: 0.027–0.073 Hz, slow‐3: 0.073–0.167 Hz, and slow‐2: 0.167–0.25 Hz), respectively. Results Patients with XT showed decreased ALFF in the bilateral parieto‐occipital sulcus (POS), and increased ALFF in the bilateral thalamus within the typical frequency band. Frequency‐dependent ALFF alterations were found in the higher visual areas such as the right lateral occipital complex (LOC). Furthermore, ALFF in the right LOC in the slow‐5 band was positively correlated with fusion control score (r = 0.70, p < 0.0001) and binocular function score (r = 0.67, p = 0.0002). Regression analyses showed that early age of onset remained the only significant explanatory factor for ALFF reduction in the right POS in the typically‐measured frequency band (also referred to as the typical frequency band) (Odds ratio, 0.038; 95% confidence interval, 0.001 to 0.075). Conclusions Our findings provide spatial information regarding the functionally disrupted regions in XT. Moreover, the frequency‐dependent ALLF alteration in the right LOC might reflect a potential plastic capacity in binocular function, which could be a potential objective index for evaluating disease severity.

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The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study

Cited by 41 publications

References 31 publications

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Central network changes in patients with advanced monocular blindness: A voxel‐based morphometric study

Disrupted neural signals in patients with concomitant exotropia

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