Central network changes in patients with advanced monocular blindness: A voxel‐based morphometric study

Abstract

Objective To study the changes in gray matter volume (GMV) in patients with advanced monocular blindness (MB) using voxel‐based morphometry (VBM). Methods Thirty‐one patients with advanced MB (25 males and six females) and 31 normal controls (25 males and six females) were enrolled. The t test was applied to determine the differences in GMV, white matter volume (WMV), and volume of cerebrospinal fluid in different regions of the brain. The local characteristics of spontaneous concentrations of brain tissue were evaluated by the VBM method. The effects of blindness duration on differences in the GMV were evaluated by correlation and regression analyses. Results Compared with the control group, the GMV was decreased in the upper right margin, bilateral insular cortex, right cingulate gyrus, left occipital gyrus, and right suboccipital lobe, and negatively correlated with blindness duration in the upper right posterior margin, bilateral insular cortex, and right cingulate cortex. Conclusions We found that patients with MB showed abnormal WMV and GMV, as evidenced by local changes in the brain. In addition, reduced GMV in specific parts of the brain was associated with the duration of blindness, which may indicate neuropathological mechanisms of visual loss in patients with MB.

Abnormal Fractional Amplitude of Low-frequency Fluctuation Changes in Patients With Diabetic Optic Neuropathy: a Functional MRI Study

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The abnormal fractional amplitude of low-frequency fluctuation changes in patients with diabetic optic neuropathy: a steady-state fMRI study

“…RPCG acts as the primary motor cortex and controls body movements, including eye movements. RACG and LMCG are important components of the limbic system, which play an important role in some stages of emotional processing and visual functions [35][36][37][38][39][40][41][42]. Therefore, the abnormal spontaneous brain activities we found in the above brain areas of DON patients were very meaningful findings and might partly explain the patient's symptoms and indicate the underlying neuropathological mechanism of DON.…”

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

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