The abnormal fractional amplitude of low-frequency fluctuation changes in patients with diabetic optic neuropathy: a steady-state fMRI study

Jiang, Yiping; Liu, Wenfeng; Pan, Yi‐Cong; Shu, Hui‐Ye; Zhang, Lijuan; Li, Qiuyu; Ge, Qian‐Min; Liang, Rong‐Bin; Zou, Gang‐Ming; Shao, Yi

doi:10.31083/j.jin2004090

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…41 Our findings are in accordance with all the above ophthalmology-related diseases. However, our results are partially disparate from several articles on the same topic, 24,42 mainly because the sample sizes in theses three articles were both relatively small, and the technologies used were different, which may cause the difference. The medial frontal gyrus and orbital gyri both belong to the prefrontal cortex, which covers the anterior part of the frontal lobe and participates in various critical cognitive and emotional processing tasks.…”

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Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy

Wang,

Xu,

Wei

et al. 2023

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Purpose This study aimed to explore the spontaneous brain activity in patients with diabetic optic neuropathy (DON) by using the amplitude of low-frequency fluctuation (ALFF) technique. Methods Sixteen DON patients and 16 age- and sex-matched healthy controls (HCs) were recruited. ALFF along with functional MRI method was used to detect the intrinsic brain activity alterations. The mean values of ALFF in DON patients and HCs were analyzed by receiver operating characteristic (ROC) curves. Pearson’s correlation analysis was used to determine the correlation between Hospital Anxiety and Depression Scale (HADS) and ALFF values of DONs. Results The DON group showed significantly increased ALFF values in the fusiform gyrus, and decreased ALFF values in the medial frontal gyrus/left frontal superior orbit/right frontal medial orbit, and left frontal inferior triangle. ROC curve analysis indicated that the accuracy of AUC was good. The anxiety scale and depression scale of the DON group were negatively correlated with the ALFF values of the medial frontal gyrus. Conclusion DON is a neurodegenerative disease involving multiple brain regions. The abnormal activity of neurons in these brain regions helps to reveal the underlying neural mechanisms of brain activity related to DON.

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confidence: 88%

“…All rearranged data were homogenized into standard Montreal Institute of Neurology EPI templates and resampled into 2×2×2 mm³cubes. 24 …”

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confidence: 99%

Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy

Wang,

Xu,

Wei

et al. 2023

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Latest Research Progress in Examination Methods for Diabetic Optic Neuropathy

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2024

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Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis

Cheng

et al. 2022

Front. Hum. Neurosci.

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AimPatients with high myopia (HM) reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls (HCs) via dynamic regional homogeneity (dReHo) analysis.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.ResultsIn the left fusiform gyrus (L-FG), right inferior temporal gyrus (R-ITG), right Rolandic operculum (R-ROL), right postcentral gyrus (R-PoCG), and right precentral gyrus (R-PreCG), dReHo values were significantly greater in patients with HM than in HCs.ConclusionPatients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM.

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The abnormal fractional amplitude of low-frequency fluctuation changes in patients with diabetic optic neuropathy: a steady-state fMRI study

Cited by 3 publications

References 41 publications

Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy

Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy

Latest Research Progress in Examination Methods for Diabetic Optic Neuropathy

Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia via dynamic regional homogeneity analysis

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