The atherosclerosis burden score

Abstract

Summary: Purpose: We carried out this study to evaluate the predictive value of atherosclerosis burden score (ABS) to predict coronary artery disease (CAD) among asymptomatic patients without known cardiovascular disease (CVD), as compared to other imaging or functional techniques, namely coronary artery calcium (CAC) score, carotid intima-media thickness (C-IMT), and ankle brachial index (ABI). Patients and methods: This prospective study included 198 asymptomatic consecutive patients referred for evaluation of their cardiovascular (CV) risk and for therapeutic advice. Traditional CV risk factors, ABS, CAC score, C-IMT, ABI and an ECG-synchronized coronary CT-angiography (CCTA) were performed for each patient. We compared the predictive values of these atherosclerosis markers to detect CAD defined as coronary stenosis ≥30% objectivated by CCTA. Results: Among the whole sample, the area under the receiver-operating characteristic curve (ROC-AUC) was significantly higher for CAC score (0.81, p=0.015) than for ABS, the reference (0.70) but these values were lower for C-IMT (0.60, p=0.16) and particularly for ABI (0.56, p=0.0015). However, among patients at intermediate risk of coronary heart disease (CHD), according to Framingham risk score (FRS), the differences between the ROC-AUC values for ABS (0.70) and CAC score (0.76, p=0.36) were less pronounced. Again, as compared to ABS, the ROC-AUC values were lower for C-IMT (0.60, p=0.21) and ABI (0.57, p=0.06). Conclusions: ABS, an ultrasonographic score based on the assessment of carotid and femoral plaque burden, predicts more accurately CAD than other non-radiation tools analyzed here, and has a similar performance to CAC in patients at intermediate CHD risk. Thus, ABS could be an appropriate non-invasive and safe method to improve the detection of high-risk patients who will benefit from a more intensive therapy for the primary prevention of CVD.

Construction of a pyroptosis-related classifier for risk prediction of acute myocardial infarction

“…Similarly, pyroptosis-related risk model had been used in order to predict the prognosis of Hepatocellular carcinoma [57]. In the present study, pyroptosis-related gene signature showed promising value in predicting the risk for AMI, moreover, which has a better value as a predictor of AMI through ROC analysis than others [58][59][60][61][62]. The model formula established in this study is simple and easy to implement.…”

Ultrasound Atherosclerosis Burden Score as a tool for predicting adverse cardiovascular events in patients with various cardiovascular risks aged 40-64 years

“…В цитируемом ранее исследовании Yerly P, et al именно значения ABS ≥3 продемонстрировали оптимальные соотношения чувствительности и специфичности в диагностике поражения коронарных артерий [9]. В более позднем исследовании, включавшем 198 пациентов, прошедших компьютерную томографию-ангиографию, также была подтверждена диагностическая ценность ABS (AUC=0,70) в отношении выявления бессимптомного поражения коронарных артерий [15]. При этом диагностическая ценность ABS превосходила таковую для толщины комплекса интима-медиа сонных артерий, лодыжечно-плечевого индекса и уступала лишь индексу коронарного кальциноза (AUC=0,81).…”

Atherosclerosis Burden of Brain‐ and Heart‐Supplying Arteries and the Relationship With Vascular Risk in Patients With Ischemic Stroke

“…It ranged from 0 to 5 points for intracranial, cervical, or coronary arteries (0, no atherosclerosis; 1, atherosclerosis without obvious lumen stenosis or stenosis <25%; 2, stenosis 25%–49%; 3, stenosis 50%–69%; 4, stenosis 70%–99%; 5, occlusion) and ranged from 0 to 2 points for aortic arteries (0, no atherosclerosis; 1, simple plaque with thickness <4 mm, and without ulceration or mural thrombus; 2, complex plaque with thickness ≥4 mm or with ulceration or mural thrombus). The second set was the “modified atherosclerosis burden score,” 18 that is, the total number of arterial segments displaying an atherosclerotic lesion in BHAs (a total of 37 segments as described above).…”