The associations of body size and body composition with left ventricular mass: impacts for indexation in adults

Hense, Hans‐Werner; Gneiting, Birgit; Muscholl, M.; Broeckel, Ulrich; Kuch, Bernhard; Doering, Angela; Riegger, Günter A.J.; Schunkert, Heribert

doi:10.1016/s0735-1097(98)00240-x

Cited by 145 publications

(119 citation statements)

References 38 publications

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“…Hypertension, ob-Open Journal of Internal Medicine esity and dyslipidemia are reported to aggravate the prevalence of these abnormalities in type 2 diabetics, comparable to a study on the occurrence of HVG (Hense and Himero [9]). Electrocardiographic abnormalities were more correlated with the association of certain risk factors such as hypertension, dyslipidemia, feminine gender, but also poor glycemic control.…”

Section: 3)) Tachycardia Was Present In 28% Of Patients Includinsupporting

confidence: 79%

Electrocardiographic Changes in Patients with Type 2 Diabetes Multicenttic Cross Sectional and Descriptive Study in Dakar

Ndour¹,

Leye²,

Codou³

et al. 2017

OJIM

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Introduction: The resting electrocardiogram is generally called upon in the evaluation of cardio-vascular risk in diabetics. Thus we proposed in this work to evaluate electrocardiographic changes in patients with type 2 diabetes. Methods: This was a cross-sectional and descriptive observation that took place from 1 January 2014 to 1 October 2014 in the Internal Medicine/Endocrinology Departments of Pikine National Hospital and Cardiology National Hospital of Grand-Yoff. Results: One hundred (100) patients consisted of 43 male and 57 female diabetics. The sex ration male/female ratio was 0.7. The average age was 58.3 years. Men were twice as likely to be active as women. Rhythm disorders were noted in 20% of patients, 13% of whom were women. Right atrial hypertrophy was found in 11% of patients and left hypertrophy in both men and women (25%). Wolf-Parkinson White syndrome was present in 2% of patients. A complete right bundle block was present in 11% of patients. Primary repolarization disorders were noted in 17% of patients and secondary in 18% of patients, postero-diaphragmatic necrosis in 14% of patients, real posterior necrosis in 2% of patients, extensive anterior necrosis in 15% of patients. The QT interval was lengthened in 21% of patients including 14 women. Left ventricular hypertrophy was present in 33% of patients and right ventricular hypertrophy was found in 10% of patients. The bivariate analysis showed that electrocardiographic abnormalities were more correlated with the association of certain risk factors such as hypertension and dyslipidemia, the feminine gender, but also the poor glycemic balance. On the other hand, physical activity and treatment had a protective effect. Conclusion: The ECG is certainly insufficient for an exhaustive exploration of the heart of the diabetic patient, but still very useful in our conditions of exercise to improve the care of our patients.

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Section: 3)) Tachycardia Was Present In 28% Of Patients Includinsupporting

confidence: 79%

Electrocardiographic Changes in Patients with Type 2 Diabetes Multicenttic Cross Sectional and Descriptive Study in Dakar

Ndour¹,

Leye²,

Codou³

et al. 2017

OJIM

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“…The reason for the incomplete age normalization might be given by the fact that the inadequate normalization achieved by indexing to height to the power of 2.7 in very small individuals was apparently ignored in the original publication, which encompassed 241 adults and 444 infants, children, and adolescents (11). LVM is likely to scale best to lean body mass (17,18), of which height, even if used with allometric correction factors, is a rather imperfect surrogate. Whereas a precise assessment of lean body mass requires elaborate technologies such as densitometry or isotope dilution studies, allometric equations utilizing height and weight allow for estimation of lean body mass.…”

Section: Discussionmentioning

confidence: 99%

Defining Left Ventricular Hypertrophy in Children on Peritoneal Dialysis

Borzych

Bakkaloğlu

Zaritsky

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Left ventricular hypertrophy (LVH) is an important end point of dialysis-associated cardiovascular disease. The objective of this study was to evaluate the effect of different pediatric reference systems on the estimated prevalence of LVH in children on chronic peritoneal dialysis (CPD).Design, setting, participants, & measurements Echocardiographic studies in 507 pediatric CPD patients from neonatal age to 19 years were collected in 55 pediatric dialysis units around the globe. We compared the prevalence of LVH on the basis of the traditional cutoff of left ventricular mass (LVM) index (Ͼ38.5 g/m 2.7 ) with three novel definitions of LVH that were recently established in healthy pediatric cohorts.Results Application of the new reference systems eliminated the apparently increased prevalence of LVH in young children obtained by the traditional fixed LVM index cutoff currently still recommended by consensus guidelines. However, substantial differences of LVM distribution between the new reference charts resulted in a marked discrepancy in estimated LVH prevalence ranging between 27.4% and 51.7%.Conclusions Although our understanding of the anthropometric determinants of heart size during childhood is improving, more consistent normative echocardiographic data from large populations of healthy children are required for cardiovascular diagnostics and research.

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“…In health, LVM is largely determined by the metabolic requirements of LBM, 5,6 which differs between ethnic groups. Compared with Caucasians, LBM is higher in American Blacks 46 and lower in Asian Indians.…”

Section: Discussionmentioning

confidence: 99%

“…However, in health LVM is largely determined by lean body mass (LBM), 5,6 and LVM indexed by BSA does not correctly identify pathological LVH in all people, especially when body composition is altered. 7 In addition, body composition varies across ethnic groups, 8,9 and indexation to BSA may not account for the resultant variation in LVM.…”

Section: Introductionmentioning

confidence: 99%

Geographic variation in left ventricular mass and mass index: a systematic review

et al. 2011

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Left ventricular (LV) hypertrophy, defined as an abnormal increase in LV mass (LVM), is an important prognostic indicator and therapeutic target. LVM is often divided by body surface area to derive indexed mass; however, this does not correctly identify pathological LV hypertrophy in all people, especially when body composition is altered, or in different ethnic groups. We evaluated published ranges of echocardiographic LVM in healthy adult populations from different countries, excluding control groups, and compared them with the American Society of Echocardiography reference ranges. A total of 33 studies met the inclusion criteria. In men and women, there was wide variation in the ranges of LVM with a tendency for the upper limit to increase geographically westward; this variation remained for indexed mass. Several ranges fell outside the upper reference limits: in men, 13 of the mass ranges and 16 of indexed mass; and in women, 8 mass and 16 indexed mass. This review has shown that current guidelines may need revision as some published series suggest that greater LV mass should be considered normal. This may be explained by ethnic differences and supports the need for widely applicable and ethnically diverse reference ranges to be established.

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The associations of body size and body composition with left ventricular mass: impacts for indexation in adults

Cited by 145 publications

References 38 publications

Electrocardiographic Changes in Patients with Type 2 Diabetes Multicenttic Cross Sectional and Descriptive Study in Dakar

Electrocardiographic Changes in Patients with Type 2 Diabetes Multicenttic Cross Sectional and Descriptive Study in Dakar

Defining Left Ventricular Hypertrophy in Children on Peritoneal Dialysis

Geographic variation in left ventricular mass and mass index: a systematic review

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