The associations between DNA methylation and depression: A systematic review and meta-analysis

Zhu, Jiahui; Bo, Hao-Hui; Liu, Bao-Peng; Jia, Cun-Xian

doi:10.1016/j.jad.2023.01.079

Cited by 15 publications

(6 citation statements)

References 83 publications

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“…Recent systematic reviews consistently found support for the link between the DNA hypermethylation of brain-derived neurotrophic factor (BDNF) and depression [ 122 , 123 , 124 ]. It is of interest to note that several metabolites posited in this paper, that are important in explaining the link between the gut microbiome, DNA methylation and depression, have already been identified as relevant to the DNA methylation of BDNF.…”

Section: Discussionmentioning

confidence: 99%

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

2023

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The effect of the intestinal microbiome on the gut–brain axis has received considerable attention, strengthening the evidence that intestinal bacteria influence emotions and behavior. The colonic microbiome is important to health and the pattern of composition and concentration varies extensively in complexity from birth to adulthood. That is, host genetics and environmental factors are complicit in shaping the development of the intestinal microbiome to achieve immunological tolerance and metabolic homeostasis from birth. Given that the intestinal microbiome perseveres to maintain gut homeostasis throughout the life cycle, epigenetic actions may determine the effect on the gut–brain axis and the beneficial outcomes on mood. Probiotics are postulated to exhibit a range of positive health benefits including immunomodulating capabilities. Lactobacillus and Bifidobacterium are genera of bacteria found in the intestines and so far, the benefits afforded by ingesting bacteria such as these as probiotics to people with mood disorders have varied in efficacy. Most likely, the efficacy of probiotic bacteria at improving mood has a multifactorial dependency, relying namely on several factors that include the agents used, the dose, the pattern of dosing, the pharmacotherapy used, the characteristics of the host and the underlying luminal microbial environment (e.g., gut dysbiosis). Clarifying the pathways linking probiotics with improvements in mood may help identify the factors that efficacy is dependent upon. Adjunctive therapies with probiotics for mood disorders could, through DNA methylation molecular mechanisms, augment the intestinal microbial active cohort and endow its mammalian host with important and critical co-evolutionary redox signaling metabolic interactions, that are embedded in bacterial genomes, and that in turn can enhance beneficial mood dispositions.

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Section: Discussionmentioning

confidence: 99%

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

2023

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“…DNA methyltransferases (DNMTs) catalyse DNA methylation by transferring the methyl group from S-adenyl methionine to carbon-5 of cytosine to form 5-methyl cytosine. 147 There are five major categories of DNMTs in mammals: DNMT1, DNMT2, DNMT3a, DNMT3b and DNMT3L. Ten-eleven translocation (TET) enzymes are involved in the demethylation of CpG regions by oxidising methylated bases, which activate gene expression and transcriptional activities.…”

Section: Effect Of Gut Microbiota-derived Scfas On Depressionmentioning

confidence: 99%

“…Depression has been linked to alterations in BDNF, which influences GABA neurotransmission, synaptic plasticity and neuronal activity. 147 148 Patients with depression have a higher level of methylation at specific CpG regions within BDNF promoters than healthy controls, which results in decreased expression of BDNF in the hippocampus. 149 Further research has investigated the effects of SCFAs on the methylation of BDNF promoters.…”

Section: Effect Of Gut Microbiota-derived Scfas On Depressionmentioning

confidence: 99%

Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cheng,

Hu,

et al. 2024

Gen Psych

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The gut microbiota is a complex and dynamic ecosystem known as the ‘second brain’. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals’ health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites of the gut microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component of the microbiota-gut-brain axis in depression. In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression are summarised with respect to chronic cerebral hypoperfusion, neuroinflammation, host epigenome and neuroendocrine alterations. Concluding remarks on the biological mechanisms related to gut microbiota will hopefully address the clinical value of microbiota-related treatments for depression.

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“…The latest research proposes that DNA methylation serves as the epigenetic mechanism, underlying the development of obesity and other metabolic disorders [42,43]. Concurrently, DNA methylation exhibits a significant association with an increased risk of depression [44]. This suggests a complex interplay between epigenetic modifications and the risk of both metabolic and mental health disorders.…”

Section: Higher Stress Level and Depressive Symptomsmentioning

confidence: 99%

The Interplay of Sarcopenic Obesity and Mental Health: A Complex Relationship

Jia Cheah,

Jin Cheah

2024

Weight Loss - A Multidisciplinary Perspective

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Obesity and mental health issues are two pressing concerns in today’s society. This chapter delves into the intriguing and multifaceted relationship between these two seemingly disparate areas of health — sarcopenic obesity and mental well-being. Sarcopenic obesity, characterised by the simultaneous presence of obesity and muscle wasting, has garnered increasing attention in recent years. Its implications go beyond physical health and extend into the realm of mental well-being as the chapter reveals. The chapter begins by offering an in-depth exploration of sarcopenic obesity, outlining its definition, prevalence and associated health risks. It explores the physiological mechanisms underpinning this condition, shedding light on how it affects the body’s composition and metabolism. Through the latest research findings, the reader gains an understanding of the intricate interplay between fat mass, muscle mass and the implications for overall health. The narrative then transitions into the critical components of comprehensive treatment and management, encompassing dietetics, medical intervention and psychological approaches.

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The associations between DNA methylation and depression: A systematic review and meta-analysis

Cited by 15 publications

References 83 publications

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions

Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

The Interplay of Sarcopenic Obesity and Mental Health: A Complex Relationship

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