Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cheng, Junzhe; Hu, Hongkun; Ju, Yumeng; Liu, Jin; Wang, Mi; Liu, Bangshan; Zhang, Yan

doi:10.1136/gpsych-2023-101374

Cited by 5 publications

(2 citation statements)

References 218 publications

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“…Immune system regulation: Some beneficial strains in the gut microbiota, such as lactobacilli and bifidobacteria ( 19 ), enhance the function of immune cells, especially the anti-tumor activity of T cells and macrophages, by producing SCFAs such as butyrate, propionate, and acetate ( 20 ). At the same time, these metabolites can promote the infiltration of immune cells in the TME, enhancing their recognition and attack ability against tumor cells ( 21 ).…”

Section: The Mutual Regulatory Effect Between Gut Microbiota and The ...mentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays a certain role in GBM, and can directly or indirectly affect the efficacy of immune checkpoint inhibitors (ICIs) in various ways. (1) The metabolites produced by gut microbiota directly affect the host’s immune homeostasis, and these metabolites can affect the function and distribution of immune cells, promote or inhibit inflammatory responses, affect the phenotype, angiogenesis, inflammatory response, and immune cell infiltration of GBM cells, thereby affecting the effectiveness of ICIs. (2) Some members of the gut microbiota may reverse T cell function inhibition, increase T cell anti-tumor activity, and ultimately improve the efficacy of ICIs by targeting specific immunosuppressive metabolites and cytokines. (3) Some members of the gut microbiota directly participate in the metabolic process of drugs, which can degrade, transform, or produce metabolites, affecting the effective concentration and bioavailability of drugs. Optimizing the structure of the gut microbiota may help improve the efficacy of ICIs. (4) The gut microbiota can also regulate immune cell function and inflammatory status in the brain through gut brain axis communication, indirectly affecting the progression of GBM and the therapeutic response to ICIs. (5) Given the importance of gut microbiota for ICI therapy, researchers have begun exploring the use of fecal microbiota transplantation (FMT) to transplant healthy or optimized gut microbiota to GBM patients, in order to improve their immune status and enhance their response to ICI therapy. Preliminary studies suggest that FMT may enhance the efficacy of ICI therapy in some patients. In summary, gut microbiota plays a crucial role in regulating ICIs in GBM, and with a deeper understanding of the relationship between gut microbiota and tumor immunity, it is expected to develop more precise and effective personalized ICI therapy strategies for GBM, in order to improve patient prognosis.

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Section: The Mutual Regulatory Effect Between Gut Microbiota and The ...mentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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“…In recent years, a growing body of research has revealed that the gut microbiota and the brain communicate in a bidirectional way, influencing each other, and these studies have also demonstrated the existence of the gut-brain axis [ 13 , 14 ]. Observational studies have shown differences in the composition of the gut microbiota between healthy individuals and patients with MDD compared to healthy controls [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome and major depressive disorder: insights from two-sample Mendelian randomization

Zhao,

Baranova,

Cao

et al. 2024

BMC Psychiatry

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Background Existing evidence suggests that alterations in the gut microbiome are closely associated with major depressive disorder (MDD). We aimed to reveal the causal relationships between MDD and various microbial taxa in the gut. Methods We used the two-sample Mendelian randomization (TSMR) to explore the bidirectional causal effects between gut microbiota and MDD. The genome-wide association studies summary results of gut microbiota were obtained from two large consortia, the MibioGen consortium and the Dutch Microbiome Project, which we analyzed separately. Results Our TSMR analysis identified 10 gut bacterial taxa that were protective against MDD, including phylum Actinobacteria, order Clostridiales, and family Bifidobacteriaceae (OR: 0.96 ∼ 0.98). Ten taxa were associated with an increased risk of MDD, including phyla Firmicutes and Proteobacteria, class Actinobacteria, and genus Alistipes (OR: 1.01 ∼ 1.09). On the other hand, MDD may decrease the abundance of 12 taxa, including phyla Actinobacteria and Firmicutes, families Bifidobacteriaceae and Defluviitaleaceae (OR: 0.63 ∼ 0.88). MDD may increase the abundance of 8 taxa, including phylum Bacteroidetes, genera Parabacteroides, and Bacteroides (OR: 1.12 ∼ 1.43). Conclusions Our study supports that there are mutual causal relationships between certain gut microbiota and the development of MDD suggesting that gut microbiota may be targeted in the treatment of MDD.

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Insomnia, OSA, and Mood Disorders: The Gut Connection

Pacheco,

Cedernaes,

Benedict

2024

Curr Psychiatry Rep

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Purpose of Review With the growing body of research examining the link between sleep disorders, including insomnia and obstructive sleep apnea (OSA), and the gut microbiome, this review seeks to offer a thorough overview of the most significant findings in this emerging field. Recent Findings Current evidence suggests a complex association between imbalances in the gut microbiome, insomnia, and OSA, with potential reciprocal interactions that may influence each other. Notably, specific gut microbiome species, whether over- or under-abundant, have been associated with variation in both sleep and mood in patients diagnosed with, e.g., major depressive disorder or bipolar disorder. Summary Further studies are needed to explore the potential of targeting the gut microbiome as a therapeutic approach for insomnia and its possible effects on mood. The variability in current scientific literature highlights the importance of establishing standardized research methodologies.

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Gut microbiota-derived short-chain fatty acids and depression: deep insight into biological mechanisms and potential applications

Cited by 5 publications

References 218 publications

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Gut microbiome and major depressive disorder: insights from two-sample Mendelian randomization

Insomnia, OSA, and Mood Disorders: The Gut Connection

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