The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais

Nimitphong, Hataikarn; Chailurkit, La‐or; Chanprasertyothin, Suwannee; Sritara, Piyamitr; Ongphiphadhanakul, Boonsong

doi:10.1186/1472-6823-13-60

Cited by 15 publications

(8 citation statements)

References 27 publications

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“…In recent years several cross-sectional studies demonstrated that serum 25(OH)D levels is inversely associated with the glycemic status (24)(25)(26). However the interventional studies, evaluating the effect of vitamin D supple-mentation on glycemic control showed inconsistent results (9,12,17,27,28).…”

Section: Glycemic Statusmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on the Glycemic Status and the Percentage of Body Fat Mass in Adults with Prediabetes: A Randomized Clinical Trial

Zarrin

Ayremlou

Ghassemi

2016

Iran Red Crescent Med J

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Background: Low serum levels of vitamin D are supposed to contribute to the incidence of diabetes; therefore, vitamin D supplementation may reduce the incidence of diabetes in individuals with prediabetes. Objectives: The aim of this current study was to examine the effect of vitamin D supplementation on the glycemic status and percentage of body fat mass in adults with prediabetes. Methods: In a 3-month randomized placebo-controlled supplementation trial, 120 eligible subjects were randomly assigned in a vitamin D or placebo group. They were stratified according to the percentage of body fat mass into four blocks to receive 1000 IU/daily vitamin D or an identical placebo tablet respectively, for 3 months. The study was conducted from January to March of 2016 in Urmia in the North West of Iran. Participants were adults aged 18 to 70 with prediabetes. The fasting blood sugar (FBS), glycated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), serum 25(OH)D levels, and percentage of body fat mass were assessed before and after the intervention. Results: The comparison of changes from baseline between two groups showed a significant inverse association between the changes in serum 25(OH)D and changes in FBS (-4.64 ± 11.38 compared with-2.11 ± 9.15 for placebo; P = 0.03), HOMA-IR (-0.73 ± 4.2 compared with 0.44 ± 4.4 for placebo, P = 0.01) and serum insulin (-1.98 ± 15.25 compared with 2.47 ± 15.85 for placebo; P = 0.007) but not in the percentage of body fat mass (-0.28 ± 0.77 compared with-0.39 ± 2.82 for placebo; P = 0.39). Conclusions: The study demonstrated that 1000 IU vitamin D supplementation for 3 months can decrease the insulin resistance in individuals with prediabetes; however, it has no significant effect on body fat mass percentage.

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Section: Glycemic Statusmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on the Glycemic Status and the Percentage of Body Fat Mass in Adults with Prediabetes: A Randomized Clinical Trial

Zarrin

Ayremlou

Ghassemi

2016

Iran Red Crescent Med J

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“…Several studies from Asia, including Thailand, reported the prevalence of vitamin D deficiency; however, these studies were performed in healthy individuals. 21 , 22 There are limited data about the prevalence and impact of vitamin D deficiency among patients with critical illness.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and association of vitamin D deficiency and mortality in patients with severe sepsis

Trongtrakul¹,

Feemuchang²

2017

IJGM

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BackgroundVitamin D is a steroid prohormone that regulates body calcium and phosphate metabolism. Recent studies have shown an association between low vitamin D status and high mortality in patients admitted to intensive care units. To date, there are limited data available specifically about severely septic patients in medical units.ObjectivesTo determine the prevalence of vitamin D deficiency in severely septic patients and its clinical outcomes, including mortality rate.MethodsA prospective observational study was conducted to investigate the prevalence of vitamin D deficiency and its association with 30-day mortality in patients with severe sepsis. Patients admitted to medical wards at our hospital between November 2014 and March 2015 were included in the study. A 25-hydroxyvitamin D level <20 ng/mL was defined as vitamin D deficiency, and <12 ng/mL as severe deficiency. For an association analysis, the patients were grouped into deficient versus not deficient and severely deficient versus not severely deficient.ResultsOne hundred and ten eligible patients were enrolled. A total of 83 patients (75%) had vitamin D deficiency and 42 (38%) had severe deficiency. Despite an insignificant higher 30-day hospital mortality rate in vitamin D deficient versus non-deficient groups (16% vs 4%, p=0.18), the differences were significant between the severely deficient versus non-severe groups (23% vs 4%, p=0.02). The odds ratio of the 30-day mortality rate was 4.83 (95% confidence interval [CI], 0.60–38.77, p=0.14) for vitamin D deficiency and 7.69 (95% CI, 2.00–29.55, p=0.003) for severe deficiency.ConclusionThe prevalence of vitamin D deficiency was very high in three-quarters of patients with severe sepsis. A significant higher mortality rate was observed, particularly in patients with severe vitamin D deficiency.

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“…Evolving data indicated that vitamin D was capable to influence pancreatic beta-cell proliferation and survival; and hence impaired vitamin D status was associated with higher prevalence and incidence of diabetes [ 21 ]. Several previous studies have shown that lower vitamin D status was associated with increased fasting blood glucose (FBG) levels [ 22 , 23 ] while other studies in Malay adults (mean age of 48.5 y; 42% male) and young Thais have yielded conflicting results [ 24 ]; some, but not all, found an association between vitamin D and the risk of diabetes mellitus [ 25 – 27 ]. Additionally, adequate vitamin D status is important for optimal function of cardiovascular system.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency in Singapore: Its Implications to Cardiovascular Risk Factors

Tey

Leong

et al. 2016

PLoS ONE

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ObjectiveVitamin D deficiency is a global health challenge and has been linked to type 2 diabetes and other chronic diseases. However, the relationship between vitamin D status, body composition, and cardiovascular risks has not been well characterized in Asian populations. The objectives of this study were to examine the factors associated with the low vitamin D levels in a sunny tropical region and to assess the role of vitamin D status in cardiovascular risk factors.Design and MethodsThis was a cross-sectional study. One hundred and fourteen healthy participants (59 males and 55 females) residing in Singapore took part in this study. Plasma 25OH-D3 concentration was measured by using LC-MS/MS. Body fat (%) was measured by using three different techniques including bioelectrical impedance analysis (BIA), BOD POD, and dual-energy X-ray absorptiometry (DEXA). Basic anthropometric measurements, fasting blood glucose (FBG), fasting serum insulin (FSI), and lipid profiles were obtained using standard protocols.ResultsApproximately 42% of the participants were vitamin D deficient (< 20 ng/mL). Vitamin D status was inversely associated with body fat (%), homeostasis model assessment of insulin resistance (HOMA-IR), and total cholesterol/high density lipoprotein (TC/HDL) ratio, while positively associated with lean body mass (LBM) and hand grip strength (HGS).ConclusionsThe high prevalence of vitamin D deficiency in a sunny tropical region reinforces the need to recognize that sunlight alone is not the precursor for optimal vitamin D status. This raises the need to investigate public health measures that will encourage exposure to sunlight without overexposure that is harmful to skin. More importantly, vitamin D deficiency is associated with increased cardiovascular risks, i.e. HOMA-IR, TC/HDL, and LDL/HDL. Future studies should attempt to elucidate the potential mechanisms.

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The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais

Cited by 15 publications

References 27 publications

The Effect of Vitamin D Supplementation on the Glycemic Status and the Percentage of Body Fat Mass in Adults with Prediabetes: A Randomized Clinical Trial

The Effect of Vitamin D Supplementation on the Glycemic Status and the Percentage of Body Fat Mass in Adults with Prediabetes: A Randomized Clinical Trial

Prevalence and association of vitamin D deficiency and mortality in patients with severe sepsis

Prevalence of Vitamin D Deficiency in Singapore: Its Implications to Cardiovascular Risk Factors

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