The association of very-low-density lipoprotein with ankle-brachial index in peritoneal dialysis patients with controlled serum low-density lipoprotein cholesterol level

Kanda, Eiichiro; Ai, Masumi; Okazaki, Mitsuyo; Maeda, Yoshitaka; Sasaki, Sei; Yoshida, Masayuki

doi:10.1186/1471-2369-14-212

Cited by 8 publications

(9 citation statements)

References 32 publications

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“…The results indicated in table (3) a significant increase in the level of ( p<0.001) in the levels of (LDL) in total serum patients compared to healthy, and that these results are consistent with the results of previous research indicated the high level (LDL) in serum blood of cancer patients and both genders and for all age groups [28] .In this case, the reason may be due to the decrease of (HDL) and the increase in the level of LDL and the oxidation rate is due to the increase in the quantities of free radicals, and that leads to decrease the levels of HDL and increased levels of LDL [29] .…”

Section: -Level Of Low-density Lipoproteins In Blood Vessels With Leukemiasupporting

confidence: 92%

“…The reason for the high low-density lipoprotein On a large amount of triglycerides, which is formed in the liver by the liver cells cortical, which works to transfer (TG) and cholesterol to the rest of the body [29] . and the process of oxidation in the body contribute to the high level of (VLDL), which leads to a reduction in the level of effectiveness of the enzyme Lipoprotein lipase located in the tissues of the body and this decrease leads to malfunction In the level of fat and a rise in the level of triglyceride in the serum where the ratio of glycerides in (VLDL) is increasing, therefore, can be explained by the rise of (TG) in (VLDL) mechanism of the same height(TG) [30] .…”

Section: -The Level Of Very-low-density Lipoproteins In Blood Vessels With Leukemiamentioning

confidence: 99%

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Study the Effectiveness of (G-6-PhD) Enzyme and the Level of Fats in People with Leukemia

Saleh¹

2020

ATMPH

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A chemo-enzymatic study of the enzyme G-6-PhD in the blood of individuals with leukemia and lipid level estimation and blood tests for cancer patients in the Kirkuk city. The study included 80 samples, 30 of them were healthy and considered as control group while 50 patients were the sample with leukemia, which was collected from the center of cancer tumors in Kirkuk, the age of the sample varied from (1 to 60) years old. The study evaluated the level of effectiveness of G-6-PhD from red blood cells by using the diagnostic kit (BioLaBo). There is a decrease in the level of G-6-PhD enzyme effectiveness, especially in the second age group where there was a clear decrease in this category compared to healthy people. In addition, serum lipid levels were measured for people with leukemia, where they found a decrease in fat levels (HDL, CHOL) and an increase of (V.LDL, LDL, T.G). Also, some blood tests were conducted in people with leukemia. There was a decrease in the level of (HB, PLT, PCV) and increase at the level of both (WBC) compared to healthy.

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Section: -Level Of Low-density Lipoproteins In Blood Vessels With Leukemiasupporting

confidence: 92%

Section: -The Level Of Very-low-density Lipoproteins In Blood Vessels With Leukemiamentioning

confidence: 99%

Study the Effectiveness of (G-6-PhD) Enzyme and the Level of Fats in People with Leukemia

Saleh¹

2020

ATMPH

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“…Laakso et al also reported that higher VLDL-C levels are associated with an increased risk of CVD in diabetic patients [29]. In dialysis, Kanda et al reported that VLDL-C is associated with peripheral artery disease (diagnosed using the ankle-brachial index) in PD patients with controlled LDL-C levels [20]. In the present study, similar results were observed; we found that elevated VLDL-C levels were associated with increased risks of all-cause and CV mortalities in patients treated with peritoneal dialysis independent of HDL-C, LDL-C and triglyceride levels.…”

Section: Discussionmentioning

confidence: 99%

“…Peritoneal dialysis treatment may further exacerbate lipoprotein abnormalities, and high levels of VLDL-C may lead the peripheral artery atherosclerosis [19, 20]. However, it is unclear whether VLDL-C level is an independent risk for mortality in PD patients.…”

Section: Introductionmentioning

confidence: 99%

Association of very Low-density Lipoprotein Cholesterol with All-cause and Cardiovascular Mortality in Peritoneal Dialysis

Xie¹,

Zhang²,

Xiang³

et al. 2017

Kidney Blood Press Res

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Background/Aims: Cardiovascular disease (CVD) is the leading cause of death in dialysis patients. Little is known about the relationship between very low-density lipoprotein cholesterol (VLDL-C) and cardiovascular mortality in these patients. Methods: A total of 1324 incident patients who began continuous ambulatory peritoneal dialysis (CAPD) therapy at our hospital between January 1, 2005, and September 30, 2014, with baseline serum VLDL-C values were investigated. The associations of the VLDL-C levels with all-cause and cardiovascular mortality were assessed. Results: The mean age of the cohort was 50.2 ± 14.8 years, and the mean VLDL-C level was 33.6 ± 18.0 mg/dl. One hundred sixty-five (12.5%) patients died during the study period. Multivariable models revealed that the high VLDL-C group was associated with significantly higher all-cause (HR, 2.08, 95% CI, 1.13 to 3.29, P = 0.002) and cardiovascular mortality (HR, 1.92, 95% CI, 1.18 to 4.29, P = 0.013) compared with the low VLDL-C group even after adjusting for various covariates. Using the VLDL-C level as a continuous variable, the hazard ratios (HRs) of all-cause and cardiovascular mortality associated with a 10-mg/dl increase in VLDL-C level were 1.12 (95% CI, 1.02 to 1.26, P = 0.025) and 1.11 (95% CI, 1.02 to 1.22, P = 0.029), respectively. VLDL-C was associated more strongly to all-cause (e.g., Akaike information criteria of 1990.205 vs. 1994.451) and cardiovascular (e.g., Akaike information criteria of 984.146 vs. 985.634) mortality than triglyceride (TG) levels. Conclusions: An elevated VLDL-C level is an independent risk factor for all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients.

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“…[23][24][25] Studies have consistently shown the ABI to have a minimum sensitivity and specificity of 90% and 98% respectively in predicting PAD, and with a minimum positive predictive value and negative predictive value of 90% and 98.63% respectively. [22][23][24][25][26][27][28][29] Despite the high burden of childhood NS, data on prevalence of PAD in children with NS is scarce. The study done in Egypt by Mohammed et al [4] among a cohort of children with NS recruited only those with steroid resistant NS, whereas the current study recruited all children with NS, irrespective of their steroid status.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of peripheral arterial disease in children with nephrotic syndrome

Akinyosoye

Solarin

Adekunle

et al. 2022

Preprint

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Peripheral arterial disease (PAD) is the least studied complication of nephrotic syndrome (NS). Risk factors which predispose children with NS to developing PAD include hyperlipidaemia, hypertension and prolonged use of steroids. The development of PAD significantly increases the morbidity and mortality associated with NS as such children are prone to sudden cardiac death. The ankle brachial index (ABI) is a tool that has been proven to have high specificity and sensitivity in detecting PAD even in asymptomatic individuals. We aimed to determine the prevalence of PAD in children with NS and to identify risk factors that can independently predict its development. A comparative cross-sectional study was conducted involving 200 subjects (100 with NS and 100 apparently healthy comparative subjects that were matched for age, sex and socioeconomic class). Systolic blood pressures were measured in all limbs using the pocket Doppler machine (Norton Doppler scan machine). ABI was calculated as a ratio of ankle to arm systolic blood pressure. PAD was defined as ABI less than 0.9. The prevalence of PAD was significantly higher in children with NS than matched comparison group (44.0% vs 6.0%, p < 0.001). Average values of waist and hip circumference were significantly higher in subjects with PAD than those without PAD (61.68± 9.1cm and 67.6± 11.2 cm vs 57.03 ± 8.3cm and 65.60± 12.5cm respectively, p< 0.005). Serum lipids (triglyceride, very low density lipoprotein, total cholesterol and low density lipoprotein) were also significantly higher in subjects with PAD than those without PAD [106.65mg/dl (67.8-136.7) vs 45.72mg/dl (37.7-61.3), 21.33mg/dl (13.6-27.3) vs 9.14mg/dl (7.5-12.3), 164.43mg/dl (136.1-259.6) vs 120.72mg/dl (111.1-142.1) and 93.29mg/dl (63.5-157.3) vs 61.84mg/dl (32.6-83.1), respectively p< 0.05]. Increasing duration since diagnosis of NS, having a steroid resistant NS and increasing cumulative steroid dose were independent predictors of PAD in children with NS; p< 0.05 respectively).

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The association of very-low-density lipoprotein with ankle-brachial index in peritoneal dialysis patients with controlled serum low-density lipoprotein cholesterol level

Cited by 8 publications

References 32 publications

Study the Effectiveness of (G-6-PhD) Enzyme and the Level of Fats in People with Leukemia

Study the Effectiveness of (G-6-PhD) Enzyme and the Level of Fats in People with Leukemia

Association of very Low-density Lipoprotein Cholesterol with All-cause and Cardiovascular Mortality in Peritoneal Dialysis

Prevalence and determinants of peripheral arterial disease in children with nephrotic syndrome

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