The association of ventricular tachycardia and endothelial dysfunction in the setting of acute myocardial infarction with ST elevation

Abstract

BackgroundVentricular tachycardia (VT) is frequently seen in ischemic settings like acute myocardial infarction with ST segment elevation (STEMI). Endothelial dysfunction (ED) represents inflammation and the loss of all protective features of the endothelium. We aimed to examine the association between VT and ED in patients with STEMI.Material/MethodsThe study included 90 subjects (30 with VT and acute STEMI, 30 with STEMI without VT, and 30 controls). Sera of all subjects were tested on ED markers by enzyme immunoassay: sICAM-1 (intracellular adhesive molecule-1), sVCAM-1 (vascular adhesive molecule-1), P- and E-selectins, and VEGF (vascular endothelial growth factor). In addition, CRP (C-reactive protein) was detected.ResultsSignificantly increased values of low-density lipoprotein, triglycerides, leukocytes, creatinine, and the number of cigarettes smoked were observed among patients with VT+STEMI in comparison to controls. The levels of E-selectin were significantly lower in the VT+STEMI group than in the other groups, while the levels of VCAM-1 were significantly higher in the groups with STEMI and VT+STEMI compared to the controls. Lower levels of VEGF were recorded in STEMI and VT+STEMI groups compared to the control group. A significant correlation between CRP and VCAM-1 in patients with VT +STEMI was demonstrated.ConclusionsWe showed that ED may have a role in the immunopathogenesis of VT in patients with STEMI. The role of sE-selectin and correlation of sVCAM-1 with CRP as possible ED predictive markers in patients with VT+STEMI should be further investigated in a large cohort of patients.

Circulating tumor necrosis factor‐α, interleukin‐1β, and interleukin‐17A estimates increased major adverse cardiac event risk in acute myocardial infarction patients

“…Moreover, it was noticed that VCAM‐1 correlated with AMI prognosis, while ICAM‐1 did not, which could be explained by that: VCAM‐1 facilitated endothelial dysfunction of cardiovascular and increased the risk of plaque fragmentation, it played a more vital and direct role in AMI patients compared with ICAM‐1. 36 Hence, it was observed that only VCAM‐1 was associated with AMI prognosis, while ICAM‐1 was not linked with the prognosis.…”