Circulating tumor necrosis factor‐α, interleukin‐1β, and interleukin‐17A estimates increased major adverse cardiac event risk in acute myocardial infarction patients

Abstract

Background Inflammatory cytokines are implicated in the development of atherosclerosis and cardiomyocyte injury during acute myocardial infarction (AMI). This study aimed to investigate the correlation of eight common inflammatory cytokines with major adverse cardiac event (MACE) risk and further establish a prognostic model in AMI patients. Methods Serum samples of 210 AMI patients and 20 angina pectoris patients were, respectively, collected at admission, to detect tumor necrosis factor‐alpha (TNF‐α), interleukin (IL)‐1β, IL‐6, IL‐8, IL‐10, IL‐17A, vascular cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule 1 (ICAM‐1) via enzyme‐linked immunosorbent assay. Results TNF‐α, IL‐6, IL‐8, IL‐17A, VCAM‐1, and ICAM‐1 were elevated (all p < 0.050); IL‐10 ( p = 0.009) was declined; IL‐1β ( p = 0.086) was not varied in AMI patients compared with angina pectoris patients. TNF‐α ( p = 0.008), IL‐17A ( p = 0.003), and VCAM‐1 ( p = 0.014) were elevated in patients with MACE occurrence compared to patients without MACE occurrence; meanwhile, they possessed a relatively good value for identifying MACE risk via receiver‐operating characteristic (ROC) analysis. Subsequent multivariate logistic regression analysis revealed that the independent risk factors for MACE contained TNF‐α (odds ratio (OR) = 1.038, p < 0.001), IL‐1β (OR = 1.705, p = 0.044), IL‐17A (OR = 1.021, p = 0.009), history of diabetes mellitus (OR = 4.188, p = 0.013), history of coronary heart disease (OR = 3.287, p = 0.042), and symptom‐to‐balloon time (OR = 1.064, p = 0.030), whose combination disclosed a satisfying prognostic value for MACE risk (area under the curve: 0.877, 95% CI: 0.817–0.936). Conclusion Elevated levels of serum TNF‐α, IL‐1β, and IL‐17A independently correlated with MACE risk in AMI patients, which perhaps provide novel auxiliary for AMI prognostic prediction.

miR‐619‐5p and cardiogenic shock in patients with ST‐segment elevation myocardial infarction

“…28 Moreover, elevated levels of TNF-alpha after MI have been associated with an increased risk of adverse events in STEMI-patients. 29 Following a completely different approach, we show how miR-619-5p through its post-transcriptional regulation explains the TNF-alphainduced severity profile in STEMI-patients with CS, especially evident in those with an adverse outcome.…”

“…IL6 and IL1B are raising great interest as possible strategies of medical targeting in myocardial infarction 26,27 after the results obtained from the CANTOS‐trial 28 . Moreover, elevated levels of TNF‐alpha after MI have been associated with an increased risk of adverse events in STEMI‐patients 29 . Following a completely different approach, we show how miR‐619‐5p through its post‐transcriptional regulation explains the TNF‐alpha‐induced severity profile in STEMI‐patients with CS, especially evident in those with an adverse outcome.…”

Optimal Management of Comorbid Patients with Spondyloarthritis: Focus on Cardiovascular Safety

“…Датское общенациональное исследование, в которое был включен 34 371 пациент с легкой формой псориаза и 2621 -с тяжелой, в том числе 607 больных ПсА, показало, что заболеваемость ССЗ и смертность от них возрастает у лиц с псориазом и ПсА, при этом указанные риски сопоставимы с таковыми при сахарном диабете [4]. В рамках российского исследования РЕМАРКА [14] при оценке традиционных факторов сердечно-сосудистого риска (ТФР) у пациентов с ранним ПсА (медиана возраста -36 (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) лет, медиана длительности заболевания -5 (3-7) месяцев) у 44% была выявлена АГ, у 56% -абдоминальное ожирение, у 64% -факт курения, у 56% -дислипидемия. Сочетание трех и более ТФР ССЗ обнаружено у 48% пациентов.…”