The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile

Abstract

IntroductionSeveral polymorphisms have been associated with obesity and type 2 diabetes in different populations.ObjectiveTo investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D.MethodsThe case–control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60–79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects.ResultsThe frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of the C allele with T2D (OR = 1.74, 95% CI = 1.003–3.084, p = 0.036), but not the AG + GG variants for BsmI (OR = 1.02, 95% CI = 0.635–1.649, p = 0.916). We can observe a significant association between carrier of the T > C variant of FokI and type 2 diabetes, adjusted for vitamin D, age, obesity (overweight and obesity), seasonality, sex and Homa-IR. Here, we show a significant association between the FokI polymorphisms (TC + CC) and T2D with an odds ratio of 1.9001 (95% CI (1.0970–3.6838), p = 0.041).ConclusionOur study suggests that the C allele (TC + CC) of the VDR-FokI gene is a possible risk factor for T2D in older people living in a community in Santiago de Chile.

The Effect of Vitamin D and FokI Vitamin D Receptor Polymorphism to 25 (OH) D, TNF-α and Nitric Oxide Levels in Diabetic Foot Patients

“…The VDR FokI gene polymorphism is the only VDR polymorphism that is different from other VDR genes which at the time of translation formed two protein products and the only form of VDR gene polymorphism that is not related to other VDR gene variants, so this makes it unique (Neyestani et al, 2013 The FokI VDR gene polymorphism found in allele differences has a genetic contribution to type 2 Diabetes due to its effect on insulin secretion. These results show that the subjects of this study who were diabetic foot ulcer sufferers had T to C mutations in the FokI gene, which indirectly became a risk factor for the occurrence of type 2 Diabetes and diabetic foot ulcer (Palomer, 2008;Angel B, 2018).…”

Association of VDR gene variant (rs1544410) with type 2 diabetes in a Pakistani cohort

“…The association of the VDR gene polymorphisms and T2DM in older people living in a community of Santiago de Chile, Chile, were previously established through a case-control study on 138 T2DM patients and 172 control subjects with ages ranging from 60-79 years. They further suggested that the C allele (TC+ CC) of the VDR-FokI gene is a possible risk factor for T2DM in older people living in a community in Santiago de Chile, Chile [10].…”

“…It has been investigated that polymorphisms in the VDR gene are associated with diabetes susceptibility. Previous studies have shown the connection of VDR polymorphism with T2DM, however, their frequency remained different across a diverse population [10].…”

Vitamin D receptor (VDR) geneFokI,BsmI,ApaI andTaqI polymorphisms and osteoporosis risk: a meta-analysis

“…VDR translocated from cytoplasm to nucleus upon activation by binding of its ligand 1-α-25-dihydroxyvitamin D3 (1-α-25(OH) 2D3) [99]. Numerous investigations have reported that VDR gene polymorphisms were connected with the onset of osteoporosis [81] and other diseases like-breast cancer [100], diabetes [101], myocardial infarction [102] and metabolic syndrome and inflammation [103]. Meta-analysis is a well established statistical tool used for combining the data of small sample sized individual studies.…”