The Association of Urinary 5-Hydroxyindoleacetic Acid and Vanillylmandelic Acid in Patients with Generalized Anxiety

Garvey, Michael J.; Noyes, Russell; Woodman, Catherine; Laukes, Cindy

doi:10.1159/000119165

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…10 Symptoms seen in patients with anxiety are triggered by increased sympathetic tone, which leads to increased circulating levels of catecholamines. 18 –20 Our study suggests that higher anxiety score is an important risk factor for radial artery vasospasm possibly triggered by increased sympathetic tone in patients with high anxiety scores.…”

Section: Discussionmentioning

confidence: 74%

Anxiety Score as a Risk Factor for Radial Artery Vasospasm During Radial Interventions

et al. 2013

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We determined the role of anxiety level on radial artery spasm during transradial coronary angiography. Eighty-one patients who had an indication for coronary angiography were enrolled. Radial artery vasospasm was determined by addressing 5 signs: persistent forearm pain, pain response to catheter manipulation, pain response to sheath withdrawal, difficult catheter manipulation after being "trapped" by the radial artery, and considerable resistance on withdrawal of sheath. Radial spasm defined as at least 2 of the 5 signs. The Hamilton Anxiety scale questionnaire was used to determine the level of anxiety. Vasospasm was observed in 19.1% of the patients. Anxiety score was significantly higher in women (11.1 ± 7.2 vs 17.6 ± 7.3; P < .001). Vasospasm was significantly correlated with female sex (P < .001, r = .43) and anxiety score (P = .007, r = .29). Female sex was associated with higher anxiety scores (P < .001, r = .43). In conclusion, higher anxiety scores and female sex are important risk factors for radial artery vasospasm.

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Section: Discussionmentioning

confidence: 74%

Anxiety Score as a Risk Factor for Radial Artery Vasospasm During Radial Interventions

et al. 2013

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“…Markovitz et al [20] found that emotional stress increases platelet activity and suggested that stressors may play an important role in vascular events such as myocardial infarction. In the case of increased stress and anxiety, serotonin binds to 5-HT-2 receptors on platelets and mediates the release of factors that promote platelet aggregation [21]. Pecknold et al [22] found that platelet 5-HT reuptake was increased in patients with major depression accompanying panic disorder.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume level in patients with generalized anxiety disorder

Almış

Aksoy

2017

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: Generalized anxiety disorder (GAD) is characterized by persistent and chronic anxiety state. Stressful life events and anxiety usually cause an increase in platelet volume and activity through various mechanisms. Mean platelet volume (MPV), which is indicative of platelet size, is accepted as an indication of platelet activity. METHOD: In this first retrospective cohort study about MPV among GAD patients, we compared complete blood count especially in terms of platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT) and MPV values of 60 GAD patients with 60 healthy controls. RESULTS: MPV was found to be significantly higher (p = .008) and platelet count was found to be significantly lower in the GAD group (p = .001). The area under the ROC curve (AUC) of MPV levels for GAD was 0.655 (95% CI: 0.557-0.754, p < .001). DISCUSSION: Increased MPV levels in GAD patients in our study supports the hypothesis of increased platelet activation due to sympathetic system activation. Also platelet levels were found to be significantly lower in GAD patients in our study. This finding is consistent with the non-linear inverse relation between platelet volume and platelet count. According to ROC curve analysis for differentiation of GAD from those in the control group, MPV would be considered to be a "poor" biochemical marker. We believe that further controlled prospective studies about this issue will be valuable. ARTICLE HISTORY

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“…Interestingly, serotonin has been shown to increase platelet aggregation and may be a method by which anxiety disorders are associated with increased cardiac events, as anxiety disorders have been associated with abnormalities in the serotonin system [73, 74]. Serotonin binds 5-hydroxytryptamine-2 (5HT-2) receptors on platelets and precipitates the release of factors enhancing platelet aggregation.…”

Section: Mechanisms Mediating the Relationships Between Anxiety Disormentioning

confidence: 99%

Anxiety Disorders and Cardiovascular Disease

Celano

Daunis

Lokko

et al. 2016

Curr Psychiatry Rep

265

173

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Anxiety and its associated disorders are common in patients with cardiovascular disease and may significantly influence cardiac health. Anxiety disorders are associated with the onset and progression of cardiac disease, and in many instances have been linked to adverse cardiovascular outcomes, including mortality. Both physiologic (autonomic dysfunction, inflammation, endothelial dysfunction, changes in platelet aggregation) and health behavior mechanisms may help to explain the relationships between anxiety disorders and cardiovascular disease. Given the associations between anxiety disorders and poor cardiac health, the timely and accurate identification and treatment of these conditions is of the utmost importance. Fortunately, pharmacologic and psychotherapeutic interventions for the management of anxiety disorders are generally safe and effective. Further study is needed to determine whether interventions to treat anxiety disorders ultimately impact both psychiatric and cardiovascular health.

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The Association of Urinary 5-Hydroxyindoleacetic Acid and Vanillylmandelic Acid in Patients with Generalized Anxiety

Cited by 14 publications

References 14 publications

Anxiety Score as a Risk Factor for Radial Artery Vasospasm During Radial Interventions

Anxiety Score as a Risk Factor for Radial Artery Vasospasm During Radial Interventions

Mean platelet volume level in patients with generalized anxiety disorder

Anxiety Disorders and Cardiovascular Disease

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