The association of triglyceride-glucose index and related parameters with hypertension and cardiovascular risk: a cross-sectional study

Miao, Huanhuan; Zhou, Zhanyang; Yang, Shijie; Zhang, Yuqing

doi:10.1038/s41440-023-01502-9

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…WHtR is a straightforward and readily accessible marker of generalized and abdominal obesity. Relevant studies have demonstrated that WHtR is more effective in identifying cardiometabolic risk factors than is waist circumference and body mass index for abdominal fat deposition, which are significantly associated with coronary heart disease [ 32 , 33 ]. Furthermore, WHtR is a better option than waist circumference for examining the association between obesity and cardiovascular disease in individuals with lower body mass indices [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose-waist to height ratio and coronary heart disease: a population-based study

Zhuang,

Wang,

Sun

et al. 2024

Lipids Health Dis

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Background The Triglyceride glucose (TyG) index-related indicators improve risk stratification by identifying individuals prone to atherosclerosis early in life. This study aimed to examine the relation between TyG-waist circumference-to-height ratio (TyG-WHtR) and coronary heart disease. Methods Data from four National Health and Nutrition Examination Surveys (NHANES) cycles between 2011 and 2018 were used for a cross-sectional study. The association between TyG-WHtR and coronary heart disease risk was examined using a multifactorial logistic regression model, and corresponding subgroup analyses were performed. Nonlinear correlations were analyzed using smooth curve fitting and threshold effects analysis. When nonlinear connections were discovered, appropriate inflection points were investigated using recursive methods. Results TyG-WHtR and coronary heart disease were significantly positively correlated in the multifactorial logistic regression analysis. Subgroup analyses and interaction tests revealed that gender, age, smoking status, and cancer were not significantly associated with this correlation (P for interaction > 0.05). Furthermore, utilizing threshold effect analysis and smooth curve fitting, a nonlinear connection with an inflection point of 0.36 was observed between TyG-WHtR and coronary heart disease. Conclusions According to this study, the American population is far more likely to have coronary heart disease if they have higher TyG-WHtR levels.

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Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose-waist to height ratio and coronary heart disease: a population-based study

Zhuang,

Wang,

Sun

et al. 2024

Lipids Health Dis

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“…Nevertheless, it is worth noting that the best TyG‐associated indices for prediction of hypertension remain controversial with incompatible conclusions. A cross‐sectional study conducted in 16 834 participants from china showed that TyG‐WC exhibited the highest diagnostic efficacy for hypertension, followed by TyG‐WHtR, TyG‐BMI, TyG‐WHR, and TyG index 34 . But, due to the nature of the cross‐sectional design, causality cannot be determined.…”

Section: Discussionmentioning

confidence: 99%

Association of hypertension with the triglyceride–glucose index and its associated indices in the Chinese population: A 6‐year prospective cohort study

Yang,

Song,

Wang

et al. 2023

J of Clinical Hypertension

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The authors aim to assess the correlation between hypertension and the triglyceride‐glucose (TyG) index and its associated indices, and to compare their abilities to identify hypertension. Four thousand eight hundred and sixty‐six non‐hypertensive participants were enrolled from the China National Health Survey in 2009. The data on new‐onset hypertension were gathered in both 2011 and 2015. The TyG index and its associated indices were derived from the fasting triglyceride, blood glucose levels, and anthropometric parameters. Multivariate logistic regression analyses and receiver operating characteristic curve analysis were used. The adjusted odds ratio (OR) and 95% confidence interval (CI) for the new‐onset hypertension for the TyG‐waist‐to‐height ratio (TyG‐WHtR), TyG‐waist circumference (TyG‐WC), TyG‐waist‐to‐hip ratio (TyG‐WHR), TyG‐body mass index (TyG‐BMI), and TyG index were 1.379 (1.230–1.546), 1.002 (1.001–1.003), 1.156 (1.069–1.251), 1.007 (1.005–1.009), and 1.187 (1.051–1.341), respectively. In addition, comparing the lowest quartile (Q1) group with the highest quartile (Q4), the adjusted OR and 95% CI for the new‐onset hypertension were found to be 1.86 (1.48–2.35), 1.93 (1.53–2.43), 1.71 (1.36–2.16), 2.00 (1.60–2.50), and 1.49 (1.19–1.88) for TyG‐WHtR, TyG‐WC, TyG‐WHR, TyG‐BMI, and TyG index, respectively, among all participants. The TyG‐WHtR had the largest area under the curve (AUC) for hypertension (AUC, 0.628; 95% CI, 0.614–0.641) in all participants. Stratified analysis also indicated that the TyG‐WHtR exhibited the greatest AUC in both males (AUC, 0.608; 95% CI, 0.587–0.629) and females (AUC, 0.648; 95% CI, 0.629–0.666). In conclusions, the TyG index and its associated indices were positively associated with hypertension. Among these indices, TyG‐WHtR was the most valuable indicator for predicting hypertension.

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“…Several studies have found a link between TyG and arterial stiffness, coronary artery calcification, hypertension, and CVD risk [12,13]. In the current study, Miao et al [10] investigated the association between the TyG index and combined TyG and anthropometric indicators (i.e., TyG-body mass index, TyG-waist circumference, TyG waist-hip ratio, and TyG waist-height ratio) with the prevalence of hypertension and CVD risk in a Chinese population. All the TyG index and TyG-related parameters were significantly associated with hypertension and CVD risk after adjusting for confounding factors.…”

mentioning

confidence: 81%

“…In the current issue of Hypertension Research, Miao et al [10] used the TyG index, which is calculated using only fasting blood glucose and triglyceride values. In addition to being inexpensive, the TyG index has been shown to be highly correlated with the insulin resistance index obtained from the euglycemic-hyperinsulinemic clamp test [11].…”

mentioning

confidence: 99%

Indicators of insulin resistance in clinical practice

Sasaki,

Ueno,

Higashi

2024

Hypertens Res

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The association of triglyceride-glucose index and related parameters with hypertension and cardiovascular risk: a cross-sectional study

Cited by 15 publications

References 35 publications

Association between triglyceride glucose-waist to height ratio and coronary heart disease: a population-based study

Association between triglyceride glucose-waist to height ratio and coronary heart disease: a population-based study

Association of hypertension with the triglyceride–glucose index and its associated indices in the Chinese population: A 6‐year prospective cohort study

Indicators of insulin resistance in clinical practice

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