Association of hypertension with the triglyceride–glucose index and its associated indices in the Chinese population: A 6‐year prospective cohort study

Abstract

The authors aim to assess the correlation between hypertension and the triglyceride‐glucose (TyG) index and its associated indices, and to compare their abilities to identify hypertension. Four thousand eight hundred and sixty‐six non‐hypertensive participants were enrolled from the China National Health Survey in 2009. The data on new‐onset hypertension were gathered in both 2011 and 2015. The TyG index and its associated indices were derived from the fasting triglyceride, blood glucose levels, and anthropometric parameters. Multivariate logistic regression analyses and receiver operating characteristic curve analysis were used. The adjusted odds ratio (OR) and 95% confidence interval (CI) for the new‐onset hypertension for the TyG‐waist‐to‐height ratio (TyG‐WHtR), TyG‐waist circumference (TyG‐WC), TyG‐waist‐to‐hip ratio (TyG‐WHR), TyG‐body mass index (TyG‐BMI), and TyG index were 1.379 (1.230–1.546), 1.002 (1.001–1.003), 1.156 (1.069–1.251), 1.007 (1.005–1.009), and 1.187 (1.051–1.341), respectively. In addition, comparing the lowest quartile (Q1) group with the highest quartile (Q4), the adjusted OR and 95% CI for the new‐onset hypertension were found to be 1.86 (1.48–2.35), 1.93 (1.53–2.43), 1.71 (1.36–2.16), 2.00 (1.60–2.50), and 1.49 (1.19–1.88) for TyG‐WHtR, TyG‐WC, TyG‐WHR, TyG‐BMI, and TyG index, respectively, among all participants. The TyG‐WHtR had the largest area under the curve (AUC) for hypertension (AUC, 0.628; 95% CI, 0.614–0.641) in all participants. Stratified analysis also indicated that the TyG‐WHtR exhibited the greatest AUC in both males (AUC, 0.608; 95% CI, 0.587–0.629) and females (AUC, 0.648; 95% CI, 0.629–0.666). In conclusions, the TyG index and its associated indices were positively associated with hypertension. Among these indices, TyG‐WHtR was the most valuable indicator for predicting hypertension.

Integration of High-Resolution LC-Q-TOF Mass Spectrometry and Multidimensional Chemical−Biological Analysis to Detect Nanomolar-Level Acetylcholinesterase Inhibitors from Different Parts of Zanthoxylum nitidum

“…The roots ofZanthoxylum nitidum (ZN) are a type of tea in southern China, which can be used to relieve neuralgia and headache . In recent years, with the aging in the Chinese population, many diseases such as hypertension, hyperglycemia, hyperlipidemia, and Alzheimer’s disease are common in the elderly. , Zanthoxyli radix is becoming increasingly popular among the elderly population. This tea contains a rich and diverse range of chemical components, mainly including alkaloids, flavonoids, coumarins, and lignans with various biological activities such as anti-inflammatory and antioxidant effects. − Zheng et al found that flavonoids in ZN possessed the antioxidant capacity by DPPH method .…”