The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Abstract

Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case-control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age-matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA-IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0Á002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0Á001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405Á45 lmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1Á019, 95% CI: 1Á001-1Á036). In addition, a LAP index greater than 21Á54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1Á270, 95% CI: 1Á174-1Á374). ConclusionIn conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.

The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double‐blind, placebo‐controlled trial

“…Increased triglycerides, total‐ and LDL‐cholesterol and decreased HDL‐cholesterol concentrations represent a common and consistent lipid disturbance in subjects with PCOS starting to appear in the second decade of life . Elevated lipid profiles in persons with PCOS would result in increased risk of CVD . CoQ10 intake decreasing oxidative stresses and participation in endothelial metabolism may result in an improvement of lipid profiles …”

“…31,32 Elevated lipid profiles in persons with PCOS would result in increased risk of CVD. 33 CoQ10 intake decreasing oxidative stresses and participation in endothelial metabolism may result in an improvement of lipid profiles. 13 This research had some limitations.…”

The effect of newly initiated exercise training on dynamic thiol / disulphide homeostasis in sedentary obese adults

“…these findings demonstrated that tDH was impaired in obese adults, which ultimately led to OS. As in this study, tDHimpairment was reported in obese adolescents with polycystic ovary syndrome by Ozler et al (2016) and in obese children by elmas et al (2017). Any change in the thiol/disulphide balance in favor of an increasing disulphide formation causes physiological and structural pathologies in various Simsek et al 2016).…”

The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome

“…Elevated lipid profiles in subjects with PCOS would result ▶table 1 General characteristics of study participants. in increased risk of CVD [37]. Several mechanisms can explain the beneficial effects of combined calcium-vitamin D supplementation on serum triglycerides and VLDL-cholesterol levels.…”