The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Abstract

Aim of the studyIn breast cancer, oestrogen receptor (ER), progesterone receptor (PgR), and HER2 (HER2/Neu) expression status are used to classify neoplasms into subtypes: Luminal A, Luminal B, HER2/Neu type, and Basallike. The aim of the present study was to establish the molecular subtypes of breast cancers and their association with tumour characteristics and reproductive factors in Mexican women.Material and methodsA total of 1326 biopsies of breast tumour tissues were analysed for ER, PR, and HER2/Neu by immunohistochemistry (IHC). Information regarding age, tumour characteristics, and node involvement profiles were collected.ResultsIHC established that the most common subtype of breast cancer was Luminal A (64.93%), followed by Basal-Like (13.88%), Luminal B (12.52%), and HER2/Neu (8.67%). T2-size tumours (> 2 cm but < 5 cm) were present in 47.59% of all patients. Univariate analysis showed that lymph node positivity (p = 0.009), stage (p = 0.013), and placement of the tumour (p = 0.001) were factors associated with breast cancer subtype.ConclusionsOur data show that IHC is useful for distinguishing different subtypes of breast cancer and that Luminal A is the most common breast cancer subtype in the Mexican population. All subtypes were associated with unfavourable clinicopathological features, suggesting that late diagnosis is an important contributor to high mortality rates in the Mexican population.

Prognostic significance of androgen receptor expression in HER2-positive and triple-negative breast cancer

“…HER2-enriched subtype and basal-like subtype comprise 20% and 10% of all BC cases, respectively. Seventy per cent of cases with basal-like subtype consist of TNBC [24,25,26,27]. TNBCs are also a heterogeneous group.…”

Análisis de la coexpresión de HER2/GRB7 y su asociación con variables clinicopatológicas en un grupo de mujeres colombianas con diagnóstico de cáncer de mama invasivo

“…HER2+ y HER2-enriquecido) y el triple negativo (13). Puntualmente, en Colombia se ha reportado que el subtipo más prevalente es el luminal B, a diferencia de otras poblaciones donde el más frecuente es el luminal A (14)(15)(16)(17). Por otro lado, estudios realizados en Colombia, donde se ha evaluado la ancestría genética de las pacientes con cáncer de mama, han revelado que mujeres con tumores del subtipo luminal B y con una mayor fracción de ancestría indígena, presentan una mayor expresión del gen ERBB2, el cual codifica para la proteína HER2, así como de otros genes localizados en la misma región del cromosoma 17, como GRB7 (18).…”