The Association of Serum 25-Hydroxyvitamin D Concentrations and Elevated Glycated Hemoglobin Values: A Longitudinal Study of Non-Diabetic Participants of a Preventive Health Program

Abstract

The prevalence of Type 2 Diabetes (T2D) is sharply on the rise, both in Canada and worldwide. As addressing its root causes, i.e., promotion of healthy lifestyles and weight management, has been largely unsuccessful, new clues for primary prevention seem essential to curbing the increasing public health burden of T2D. In the present study, we examined whether improvements in vitamin D status, i.e., serum 25-hydroxyvitamin D [25(OH)D] concentrations, are paralleled by a reduction in the risk for reaching adverse glycated hemoglobin (HbA1c) levels in a community sample of non-diabetic volunteers participating in a preventive health program that encourages the use of vitamin D. Repeated observations on 6565 participants revealed that serum 25(OH)D concentrations increased from 90.8 to 121.3 nmol/L, HbA1c values decreased from 5.6% to 5.5%, and the prevalence of having HbA1c values ≥ 5.8% decreased from 29.5% to 17.4% while in the program. Compared to participants who did not increase their 25(OH)D concentrations during follow-up, those who increased their 25(OH)D concentrations with 50 nmol/L or more were 0.74 times as likely to achieve elevated HbA1c values at follow-up (p = 0.03). These findings suggest that public health initiatives that promote vitamin D status along with healthy lifestyles in the population at large may alleviate the future public health burden associated with T2D.

Association of vitamin d with glycemic control in Saudi patients with type 2 diabetes: A retrospective chart review study in an emerging university hospital

“…This high percentage of population warrants attention on this issue and demands formulation of guidelines for proper dosage and duration of vitamin D supplementation. The literature supports the idea that even in healthy non‐diabetic individuals’ proper administration of vitamin D may help in lowering the HbA1c levels . In a recent study, vitamin D supplementation has shown a decline in HbA1c levels from 5.6% to 5.5% in non‐diabetic patients with above average vitamin D levels and those who were below baseline levels but improved after vitamin D intake.…”

“…Our results showed that type 2 diabetic population had defi- tamin D may help in lowering the HbA1c levels. 17 In a recent study, vitamin D supplementation has shown a decline in HbA1c levels from 5.6% to 5.5% in non-diabetic patients with above average vitamin D levels and those who were below baseline levels but improved after vitamin D intake. Although a decline of 0.1% seems very small, lowering of HbA1c levels from 0.1% to 0.2% have shown to reduce the risk of diabetes development by 6% and 13%, respectively, in self-reporting patients with diabetes.…”

“…The poor status of vitamin D may play a critical role in T2DM development. However, only some prospective studies on the association and mechanism exist and how vitamin D affects the T2DM risk is specifically not clear . Therefore, it is essential to explore whether the vitamin D levels have any influence on glycemic control in Saudi patients with T2DM diabetes.…”

“…However, only some prospective studies on the association and mechanism exist and how vitamin D affects the T2DM risk is specifically not clear. [16][17][18][19] Therefore, it is essential to explore whether the vitamin D levels have any influence on glycemic control in Saudi patients with T2DM diabetes. The study aims to determine the frequency of good and poor glycemic control and an association between vitamin D deficiency in addition to poor glycemia control among patients presenting with T2DM.…”

Evaluating the Use of Vitamin D Supplementation to Improve Glycaemic Outcome in Type 2 Diabetes Mellitus Patients: A Systematic Review of Evidence

“…The authors thought to separate this study from the studies that compared vitamin D with placebo, since the study has a different comparator which may affect the heterogeneity of the study results. For example, a longitudinal study by Munasinghe et al [50] found that the mean This study showed that vitamin D supplementation in patients with T2DM did not significantly reduce insulin resistance. Comparably, Seida et al [49] included six studies that examined the effects of vitamin D supplementation on HOMA-IR in T2DM patients [55].…”