Association of vitamin d with glycemic control in Saudi patients with type 2 diabetes: A retrospective chart review study in an emerging university hospital

Abstract

Background Vitamin D (mainly 25‐hydroxyvitamin D, 25[OH]D) has stimulated increasing interest in Saudi Arabia over the current years due to its association with several different chronic diseases such as diabetes. This study aims to ascertain whether the vitamin D level has any influence on glycemic control in Saudi patients with type 2 diabetes (T2DM). Method This retrospective study included 200 patients with T2DM who visited Prince Sattam Bin Abdulaziz University Hospital between January 2015 and December 2015. Venous blood was collected and examined for “serum/plasma levels of 25(OH)D” and related variables using kit methods. HbA1C levels <7% and ≥7% were taken as indicators of good and poor glycemic control, respectively. An association between vitamin D deficiency and poor glycemic control was determined using multinomial logistic regression analysis. Results Among the total of 200 patients with type 2 diabetes, 118 (59%) were female and 82 (41%) were males with the mean age 42.4 ± 14.8 years. Good glycemic control (HbA1c < 7) was observed in 127 (63.5%), and poor glycemic control (HbA1c > 7) was found in 73(36.5%). The mean serum 25(OH)vit D was 20.27 ± 8.66 ng/mL, with (52% vs 82%; P ≤ .001) of subjects identified to have vitamin D deficiency in good and poor glycemic control groups, respectively. Conclusion Taken together, our results demonstrated an association of vitamin D level with poor glycemic control in patients with type 2 diabetes. However, additional studies with larger sample size from local population are warranted in future to confirm and extend the findings of the present study.

Hypovitaminosis D and the endocrine phenotype of COVID-19

“…In fact, reduced 25OHVD levels were hypothesized to be involved in the pathophysiology of diabetes-related skeletal fragility [ 87 ]. Recently, low circulating VD was reported to be associated with poor glycemic control in diabetic patients [ 88 ]. Moreover, large prospective studies suggested that low VD may predispose to a higher risk of developing impaired fasting glucose and diabetes [ 89 , 90 ].…”

Assessment of diabetes self-management among diabetic patients attending Jeddah Care Center for Diabetes, Saudi Arabia.

“…However, we demonstrated a relatively high level of poor glycemic control (48%) among patients with T1DM and T2DM. Similarly, recent studies carried out in Riyadh and Al Kharj showed that 43.13% and 44.5% of patients had uncontrolled diabetes, respectively (18,19). Other national studies have shown alarming levels in T2DM, where suboptimal HbA1c values were reported among 74.0% of patients in Jizan (20) and 73.8% in Al-Madinah(21).…”

Is There is a Correlation between Vitamin D Status and Glycemic Control (HBa1c) in Patients with Type 2 Diabetes Mellitus: Review Article with Meta-Analysis

“…Dhia J. al-Timimi et al, 2013 (23) and Khaled . Al Dossari et al, (24) study found that the diabetic patients with poor glycemic control have lower vitamin D status and higher predominance of low 25(OH) D status when compared with diabetic patients who have fair and good glycemic control. Giacomo Zoppini et al (25) found that status of vitamin D is correlated independently with Hba1c level when the adjustment for some confounding factors like diabetes period, age and glycosylated hemoglobin occur .…”